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L.A. Wozniak M. Janicka M. Bukowiecka-Matusiak 《Journal of organometallic chemistry》2005,690(10):2658-2663
Chimeric oligonucleotides with incorporated diastereomerically pure dinucleoside(3′,5′)-methylphosphonothioates and their oxo- and seleno- congeners of known absolute configuration are reported. The relation between stability of the hybrid duplexes with complementary DNA and RNA and their structure is analyzed in context of absolute configuration of the P-chiral internucleotide bonds. 相似文献
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Katarzyna Kulik Renata Kaczmarek Janina Baraniak Katarzyna Ślepokura Sergei Gryaznov 《Tetrahedron letters》2017,58(23):2276-2279
A new approach for the synthesis of dinucleoside-(N3′ → P5′)-phosphoramidothioates based on the Atherton–Todd reaction has been developed using nucleoside H-thiophosphonates and 3′-amino-2′,3′-dideoxynucleosides with an unprotected 5′-hydroxyl group. A mixture of P-diastereomers of dinucleosides was separated by column chromatography into fast migrating and slow migrating isomers. Based on single crystal X-ray diffraction analysis, the absolute configuration at the phosphorus atom in the slow eluting diastereomer of the dinucleoside-(N3′ → P5′)-phosphoramidothioate GNPSGNHTr was assigned as Rp. 相似文献
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《Mendeleev Communications》2022,32(5):622-623
Bis(hydroxymethyl)(2-pyridyl)- and bis(hydroxymethyl)-[(2-pyridyl)ethyl]phosphines on heating to 180 °C undergorearrangement leading to racemic P-chiral tertiary P-methyl-P-(hydroxymethyl)-containing phosphine oxides. The spontaneous self-resolution of these enantiomer mixtures during the crystallization was demonstrated. 相似文献
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Yun-Suk Jang Dr. Michael Dieckmann Prof. Dr. Nicolai Cramer 《Angewandte Chemie (International ed. in English)》2017,56(47):15088-15092
An enantioselective C−H amidation of phosphine oxides by using an iridium(III) catalyst bearing an atropchiral cyclopentadienyl (Cpx) ligand is reported. A very strong cooperative effect between the chiral Cpx ligand and a phthaloyl tert-leucine enabled the transformation. Matched–mismatched cases of the different acid enantiomers are shown. The amidated P-chiral arylphosphine oxides are formed in yields of up to 95 % and with excellent enantioselectivities of up to 99:1 er. Enantiospecific reduction provides access to valuable P-chiral phosphorus(III) compounds. 相似文献
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Access to P‐ and Axially Chiral Biaryl Phosphine Oxides by Enantioselective CpxIrIII‐Catalyzed C−H Arylations 下载免费PDF全文
Yun‐Suk Jang Dr. Łukasz Woźniak Dr. Julia Pedroni Prof. Dr. Nicolai Cramer 《Angewandte Chemie (International ed. in English)》2018,57(39):12901-12905
An enantioselective C?H arylation of phosphine oxides with o‐quinone diazides catalyzed by an iridium(III) complex bearing an atropchiral cyclopentadienyl (Cpx) ligand and phthaloyl tert‐leucine as co‐catalyst is reported. The method allows access to a) P‐chiral biaryl phosphine oxides, b) atropo‐enantioselective construction of sterically demanding biaryl backbones, and also c) selective assembly of axial and P‐chiral compounds in excellent yields and diastereo‐ and enantioselectivities. Enantiospecific reductions provide monodentate chiral phosphorus(III) compounds having structures and biaryl backbones with proven importance as ligands in asymmetric catalysis. 相似文献
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