Access to P‐ and Axially Chiral Biaryl Phosphine Oxides by Enantioselective CpxIrIII‐Catalyzed C−H Arylations |
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| Authors: | Yun‐Suk Jang Dr ?ukasz Wo?niak Dr Julia Pedroni Prof?Dr Nicolai Cramer |
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| Affiliation: | 1. http://isic.epfl.ch/lcsa;2. Laboratory of Asymmetric Catalysis and Synthesis, EPFL SB ISIC LCSA, BCH 4305, CH-, Lausanne, Switzerland |
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| Abstract: | An enantioselective C?H arylation of phosphine oxides with o‐quinone diazides catalyzed by an iridium(III) complex bearing an atropchiral cyclopentadienyl (Cpx) ligand and phthaloyl tert‐leucine as co‐catalyst is reported. The method allows access to a) P‐chiral biaryl phosphine oxides, b) atropo‐enantioselective construction of sterically demanding biaryl backbones, and also c) selective assembly of axial and P‐chiral compounds in excellent yields and diastereo‐ and enantioselectivities. Enantiospecific reductions provide monodentate chiral phosphorus(III) compounds having structures and biaryl backbones with proven importance as ligands in asymmetric catalysis. |
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| Keywords: | asymmetric catalysis C− H activation chiral Cp ligands iridium P-chirality |
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