排序方式: 共有11条查询结果,搜索用时 31 毫秒
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Yevheniia Velihina Thomas Scattolin Denys Bondar Stepan Pil'o Nataliya Obernikhina Olesksiy Kachkovskyi Ivan Semenyuta Isabella Caligiuri Flavio Rizzolio Volodymyr Brovarets Yevgen Karpichev Steven P. Nolan 《Helvetica chimica acta》2020,103(12):e2000169
New potential bioactive oxazolopyrimidines have been synthesized using two main approaches: the pyrimidine ring annulation on a functionalized oxazole and the benzoyl bromide trimerization followed by rearrangement and formation of the oxazolo[5,4-d]pyrimidine scaffold. The docking analyzes have shown that 7-piperazine substituted oxazolo[4,5-d]pyrimidines 8a – 8c could be potential VEGFR2 inhibitors with high free energy of ligand–protein complex formation (ΔG: −10.1, −9.6, −9.8 kcal/mol, respectively). In vitro antitumor assays confirmed theoretical predictions that oxazolo[4,5-d]pyrimidines 8a – 8c containing positively charged piperazine moiety should demonstrate significantly higher cytotoxic effects. 4-[5-(4-Chlorophenyl)-2-phenyl[1,3]oxazolo[4,5-d]pyrimidin-7-yl]piperazin-1-ium trifluoroacetate ( 8c ) exhibited a slightly higher antiproliferative effect (IC50=0.21 μm ) than doxorubicin (IC50=0.36 μm ) on MDA-MB-231 cell line and has relatively good results on OVCAR-3 (IC50=1.7 μm ) and HCT-116 (IC50=0.24 μm ) cells. 相似文献
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Yevheniia Husak Joanna Michalska Oleksandr Oleshko Viktoriia Korniienko Karlis Grundsteins Bohdan Dryhval Sahin Altundal Oleg Mishchenko Roman Viter Maksym Pogorielov Wojciech Simka 《Molecules (Basel, Switzerland)》2021,26(7)
The biodegradable metals, including magnesium (Mg), are a convenient alternative to permanent metals but fast uncontrolled corrosion limited wide clinical application. Formation of a barrier coating on Mg alloys could be a successful strategy for the production of a stable external layer that prevents fast corrosion. Our research was aimed to develop an Mg stable oxide coating using plasma electrolytic oxidation (PEO) in silicate-based solutions. 99.9% pure Mg alloy was anodized in electrolytes contained mixtures of sodium silicate and sodium fluoride, calcium hydroxide and sodium hydroxide. Scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), contact angle (CA), Photoluminescence analysis and immersion tests were performed to assess structural and long-term corrosion properties of the new coating. Biocompatibility and antibacterial potential of the new coating were evaluated using U2OS cell culture and the gram-positive Staphylococcus aureus (S. aureus, strain B 918). PEO provided the formation of a porous oxide layer with relatively high roughness. It was shown that Ca(OH)2 was a crucial compound for oxidation and surface modification of Mg implants, treated with the PEO method. The addition of Ca2+ ions resulted in more intense oxidation of the Mg surface and growth of the oxide layer with a higher active surface area. Cell culture experiments demonstrated appropriate cell adhesion to all investigated coatings with a significantly better proliferation rate for the samples treated in Ca(OH)2-containing electrolyte. In contrast, NaOH-based electrolyte provided more relevant antibacterial effects but did not support cell proliferation. In conclusion, it should be noted that PEO of Mg alloy in silicate baths containing Ca(OH)2 provided the formation of stable biocompatible oxide coatings that could be used in the development of commercial degradable implants. 相似文献
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Dr. Aleksandr Savateev Dr. Nadezda V. Tarakina Dr. Volker Strauss Dr. Tanveer Hussain Katharina ten Brummelhuis José Manuel Sánchez Vadillo Yevheniia Markushyna Stefano Mazzanti Dr. Alexander P. Tyutyunnik Dr. Ralf Walczak Dr. Martin Oschatz Prof. Dirk M. Guldi Prof. Amir Karton Prof. Markus Antonietti 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(35):15172-15180
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Dr. Yevheniia Smortsova Dr. Clément Falaise Anam Fatima Dr. Minh-Huong Ha-Thi Prof. Rachel Méallet-Renault Dr. Karine Steenkeste Dr. Serge Al-Bacha Dr. Tesnim Chaib Dr. Loïc Assaud Dr. Marc Lepeltier Dr. Mohamed Haouas Dr. Nathalie Leclerc Dr. Thomas Pino Prof. Emmanuel Cadot 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(68):17094-17103
Polyoxothiometalate ions (ThioPOM) are active hydrogen-evolution reaction (HER) catalysts based on modular assembly built from electrophilic clusters {MoSx} and vacant polyoxotungstates. Herein, the dumbbell-like anion [{(PW11O39)Mo3S4(H2O)3(OH)}2]8− exhibits very high light-driven HER activity, while the active cores {Mo3S4} do not contain any exposed disulfido ligands, which were suspected to be the origin of the HER activity. Moreover, in the catalyst architecture, the two central {Mo3S4} cores are sandwiched by two {PW11O39}7− subunits that act as oxidant-resistant protecting groups and behave as electron-collecting units. A detailed photophysical study was carried out confirming the reductive quenching mechanism of the photosensitizer [Ir(ppy)2(dtbbpy)]+ by the sacrificial donor triethanolamine (TEOA) and highlighting the very high rate constant of the electron transfer from the reduced photosensitizer to the ThioPOM catalyst. Such results provide new insights into the field of molecular catalytic systems able to promote high HER activity. 相似文献
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F. I. Danilov A. V. Tsurkan E. A. Vasil’eva S. A. Korniy T. A. Cheipesh V. S. Protsenko 《Russian Journal of Applied Chemistry》2017,90(7):1148-1153
Deposition of Fe/TiO2 composite coatings from a colloidal methanesulfonate electrolyte containing titanium dioxide hydrosol was studied. The TiO2 content in the composite increases with increasing the dispersed phase content and decreasing the current density. Incorporation of TiO2 particles into the iron matrix resilts in an increase in the microhardness of the deposit. The electroplated Fe/TiO2 composite coating was used as a heterogeneous photocatalyst for the decomposition of an organic dye under the action of UV radiation. 相似文献
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Demetra S. Achilleos Wenxing Yang Hatice Kasap Aleksandr Savateev Yevheniia Markushyna James R. Durrant Erwin Reisner 《Angewandte Chemie (International ed. in English)》2020,59(41):18184-18188
A sunlight‐powered process is reported that employs carbon dots (CDs) as light absorbers for the conversion of lignocellulose into sustainable H2 fuel and organics. This photocatalytic system operates in pure and untreated sea water at benign pH (2–8) and ambient temperature and pressure. The CDs can be produced in a scalable synthesis directly from biomass itself and their solubility allows for good interactions with the insoluble biomass substrates. They also display excellent photophysical properties with a high fraction of long‐lived charge carriers and the availability of a reductive and an oxidative quenching pathway. The presented CD‐based biomass photoconversion system opens new avenues for sustainable, practical, and renewable fuel production through biomass valorization. 相似文献
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Dr. Yevheniia Smortsova Jérémy Gaillard Dr. François-Alexandre Miannay Prof. Jean-Paul Cornard 《Chemphyschem》2020,21(24):2680-2691
In this work, we investigated for the first time morin in MeOH at different pH values by picosecond time-resolved fluorescence. We identified the two species responsible for the fluorescence at low and high pH. The solvated morin-solvent hydrogen-bonded complex has been experimentally observed for the first time. We give also the typical fluorescence spectra as well as the fluorescence lifetimes of the probable emitting species. In this work we put forward new insights concerning the contribution of free morin to the fluorescence. We hope that these new data improve the accuracy of the interpretation of the cation:morin complexes titration using fluorescence signal. 相似文献