ICP-AES法测定高温合金中5种非金属元素

本文研究了快速测定高温合金中5种非金属元素(As、B、P、Se、Si)的分析方法,以满足高温合金行业对非金属元素检测的需求。利用王水和高氯酸对高温合金进行酸溶解,并系统研究了基体元素和共存元素对分析元素谱线的光谱干扰情况,同时进行了分析谱线的选择。5种非金属元素的检出限在5.5 ～ 11.9 ug/ml,5次数据的相对标准偏差(RSD,n=5)为0.9 % ～ 7 %,各元素的回收率在96 % ～ 102 %之间,该方法适用于高温合金中非金属元素的测定。     

基于实际路网情境的配送车辆调度优化

在实际路网情境下结合车道数、车道宽度、路口信号灯设置等路网物理特性,构建了考虑综合交通阻抗的多车型车辆调度模型,提出了两阶段求解策略:第1阶段设计了改进A-star精确解算法用于计算客户时间距离矩阵;第2阶段针对实际路网的特征设计了混合模拟退火算法求解调度方案。以大连市某配送中心运营实例进行路网情境仿真试验,结果表明:改进A-star算法较改进Dijkstra算法具有更短的路径搜索时间;混合模拟退火算法求解结果较实际调度方案优化了13.1% 的综合成本;路网增流、区域拥堵和路段禁行三类路网情境均能对配送方案的车辆配置、路径选择、客户服务次序、作业时间和违约费用等5方面内容产生干扰,调度计划的制定需要详细考虑这些因素的变化。     

Cytotoxicity of guanine-based degradation products contributes to the antiproliferative activity of guanine-rich oligonucleotides

Guanine-rich oligonucleotides (GROs) have attracted considerable attention as anticancer agents, because they exhibit cancer-selective antiproliferative activity and can form G-quadruplex structures with higher nuclease resistance and cellular uptake. Recently, a GRO, AS1411 has reached phase II clinical trials for acute myeloid leukemia and renal cell carcinoma. The antiproliferative activity of GROs has been associated with various protein targets; however the real mechanisms of action remain unclear. In this study, we showed evidence that antiproliferative activity of GROs (including AS1411) is mainly contributed by the cytotoxicity of their guanine-based degradation products, such as monophosphate deoxyguanosine (dGMP), deoxyguanosine (dG) and guanine. The GROs with lower nuclease resistance exhibited higher antiproliferative activity. Among nucleotides, nucleosides and nucleobases, only guanine-based compounds showed highly concentration-dependent cytotoxicity. Our results suggest that it is necessary to reconsider the cancer-selective antiproliferative activity of GROs. Since guanine-based compounds are endogenous substances in living organisms, systematic studies of the cytotoxicity of these compounds will provide new information for the understanding of certain diseases and offer useful information for drug design.     

Bounds on partial derivatives of NURBS surfaces

In this paper, we estimate the partial derivative bounds for Non-Uniform Rational B-spline(NURBS) surfaces. Firstly, based on the formula of translating the product into sum of B-spline functions, discrete B-spline theory and Dir function, some derivative bounds on NURBS curves are provided. Then, the derivative bounds on the magnitudes of NURBS surfaces are proposed by regarding a rational surface as the locus of a rational curve. Finally, some numerical examples are provided to elucidate how tight the bounds are.     

The Influencing Mechanism of Acidity on the Oxidation Peak Currents of Uric Acid and Ascorbic Acid at the PACPE by Cyclic Voltammetry

In this paper, a pre‐anodized carbon paste electrode (PACPE) is fabricated by a simple electrochemical pretreatment method, which can be used for the simultaneous determination of uric acid (UA) and ascorbic acid (AA). The influencing mechanism of the acidity on the size of oxidation peak current (i_p,a) of UA and AA is discussed in detail. According to the results, in different pH conditions, the intensity of hydrogen bonding between UA, AA and the surface of PACPE, the degree of reduction reaction at the auxiliary electrode, and the structural configurations of UA and AA with different species in reaction system have evident influence on the size of oxidation peak current. In pH 7.00 phosphate buffer solution, the calibration curves for UA and AA are obtained in the range of 5.0 x 10^‐7–5.0 x 10^‐5 mol/L and 3.0 x 10^‐5–5.0 x 10^‐3 mol/L, respectively. The detection limits for UA and AA are found to be 2.0 x 10^‐8 mol/L and 1.2 x 10^‐6 mol/L, respectively. This proposed method has been successfully applied to determine UA and AA in human urine simultaneously with satisfactory results.     

反应堆蒙特卡罗临界模拟中均匀裂变源算法的改进

在反应堆pin-by-pin精细建模及蒙特卡罗模拟计算研究中, 由于不同栅元的功率密度差异较大, 导致蒙特卡罗方法临界计算的样本在不同栅元之间的分配不均衡, 由此引起栅元内的各种计数的统计误差差异较大. 为使大部分栅元内计数的统计误差降至一个合理的水平, 单纯增加总样本已不是一个高效的解决方法. 通过在特定临界计算迭代算法的基础上改进并实现均匀裂变源算法的思想, 对大亚湾压水堆pin-by-pin模型取得了具有较高效率的数值结果. 本工作为具有自主知识产权的蒙特卡罗粒子输运模拟软件JMCT最终达到反应堆pin-by-pin模型(包括一系列国际基准模型)的模拟性能要求提供了一个有效的工具.     

大型低速二元风洞侧壁边界层控制及对单段翼型实验结果的影响

本文简述了ＮＦ－３风洞二元实验段侧壁边界层吹除控制系统及具有吹气的模型实验方法，给出了不同吹气系数对风洞边界层的控制效果以及对相对厚度为７％的单段翼型实验结果的影响。初步实验研究结果表明，该控制系统能有效地改善风洞侧壁边界层的流动状态，减小侧壁干扰，改善翼型实验中的二元流动特性     

Ultrasound-assisted Extraction of Kamebakaurin from Rabdosia excisa by Response Surface Methodology

For the efficient extraction of kamebakaurin（KA）, the ultrasound-assisted extraction（UAE） of KA from Rabdosia excisa（R, excisa） via response surface methodology（RSM） was investigated with high-performance liquid chromatography（HPLC）. Effects of the experimental parameters such as extraction solvent, ratio of liquid to plant material, extraction time and extraction temperature on the extracting efficiency of KA from R. excisa were evaluated, and the purity of KA in residual was calculated. The optimized conditions were 65.5%（volume fraction） acetone, 35 ℃, time of 24.6 min with ultrasound of 80 W/L, 40 kHz, ratio of liquid to plant material at 30：1（mL/g）. The maximum yield of KA is 0.708 mg/kg, with mean purity of 6.09%, indicating that ultrasound-assisted extraction is a feasible and useful method for extracting KA from R. excisa.