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This work described a sensitive method for determination of metoprolol in rabbit plasma.The method involved purification by ultrafiltration,derivatization with fluorescein isothiocyanate,determination by capillary electrophoresis(CE) coupled with laser-induced fluorescence(LIF) detector.Other components in plasma including a variety of amino acids and proteins did not interfere with the determination of metoprolol in experimental condition.The assay had a wide range(2.0-500 ng/mL) of linearity and a detection limit of 0.8 ng/mL.The intra- and inter-day precisions were satisfactory with relative standard deviation(RSD) less than 10.0%and accuracy within 10.0%.This method was successfully applied to pharmacokinetic study of metoprolol in rabbit blood. 相似文献
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A novel high performance liquid chromatography-chemiluminescence(HPLC-CL) method for investigation of in vitro metabolism of repaglinide in pig liver microsomes with microdialysis sampling technique was developed.The chromatographic separation was performed on a Hypersil BDS-C18 column with an isocratic mobile phase consisting of methanol and 0.01 mol/L KH2PO4(pH 3.0)(volume ratio 75:25) at a flow rate of 1.0 mL/min.The detection was based on the chemiluminescence reaction of repaglinide with acidic potassium permanganate(KMnO4) and tris(2,2’-bipyridyl)ruthenium(Ⅲ)(Ru(bpy)33+),which was immobilized on the cationic ion-exchange resin for obtaining high sensitivity and reducing consumption of expensive reagent. 相似文献
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Hong She Wang Wei Xing Zhao 《中国化学快报》2011,22(8):911-914
An efficient magnesium bistrifluoromethanesulfonimide[Mg(NTf_2)_2]catalyzed hydroalkylation of aromatic olefins with 1,3- diketones under solvent-free conditions has been developed.The reactions proceed smoothly to give the desired products in good yields in short reaction times. 相似文献
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本文通过定义新的谱集,给出了算子满足a-Browder定理和a-Weyl定理的充要条件,运用了文章中新定义的谱集,研究了解析hyponormal算子的a-Weyl定理. 相似文献
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运用声学基础理论,讨论了激光入射到液体中,激光能量与声信号强度间的变化关系.发现激光能量与声信号强度之间存在着对数线形关系.根据液体中光声信号的连续性,得到了一种求取液体光击穿阈值的新方法. 相似文献
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非交换Lipschitz-φ算子代数 总被引:4,自引:0,他引:4
本文引入由紧距离空间(K,d)到给定Banach代数A中的Lipschitz-φ算子构成的非交换Banach代数L~φ(K,A)与l~φ(K,A),证明了它们都是由K到A的全体连续算子构成的非交换Banach代数C(K,A)的子代数,并且关于范数||f||φ=L_φ(f)+||f||∞是Banach代数,研究了不同 Lipschitz尺度函数φ对应的大(小)Lipschitz代数之间的关系。特别当φ(t)=t~α时,引入了极限代数lim_(α→0+)l~α(K,A),lim_(α→+∞)l~α(K,A),lim_(α→0+)L~α(K,A)与lim_(α→+∞)L~α(K,A)以及距离空间的Lipschitz连通性,得到了lim_(α→+∞)l~α(K,A)=A的充要条件,也给出了lim_(α→0+)L~α(K,A)=C(K,A)的条件。 相似文献