Chemical Profiles and Pharmacological Properties with in Silico Studies on Elatostema papillosum Wedd

The current study attempted, for the first time, to qualitatively and quantitatively determine the phytochemical components of Elatostema papillosum methanol extract and their biological activities. The present study represents an effort to correlate our previously reported biological activities with a computational study, including molecular docking, and ADME/T (absorption, distribution, metabolism, and excretion/toxicity) analyses, to identify the phytochemicals that are potentially responsible for the antioxidant, antidepressant, anxiolytic, analgesic, and anti-inflammatory activities of this plant. In the gas chromatography-mass spectroscopy analysis, a total of 24 compounds were identified, seven of which were documented as being bioactive based on their binding affinities. These seven were subjected to molecular docking studies that were correlated with the pharmacological outcomes. Additionally, the ADME/T properties of these compounds were evaluated to determine their drug-like properties and toxicity levels. The seven selected, isolated compounds displayed favorable binding affinities to potassium channels, human serotonin receptor, cyclooxygenase-1 (COX-1), COX-2, nuclear factor (NF)-κB, and human peroxiredoxin 5 receptor proteins. Phytol acetate, and terpene compounds identified in E. papillosum displayed strong predictive binding affinities towards the human serotonin receptor. Furthermore, 3-trifluoroacetoxypentadecane showed a significant binding affinity for the KcsA potassium channel. Eicosanal showed the highest predicted binding affinity towards the human peroxiredoxin 5 receptor. All of these findings support the observed in vivo antidepressant and anxiolytic effects and the in vitro antioxidant effects observed for this extract. The identified compounds from E. papillosum showed the lowest binding affinities towards COX-1, COX-2, and NF-κB receptors, which indicated the inconsequential impacts of this extract against the activities of these three proteins. Overall, E. papillosum appears to be bioactive and could represent a potential source for the development of alternative medicines; however, further analytical experiments remain necessary.     

Optimized spacer layer thickness for plasmonic-induced enhancement of photocurrent in a-Si:H

Journal of Nanoparticle Research - Plasmonic interfaces consisting of silver nanoparticles of different sizes (50–100&;nbsp;nm) have been processed by the self-assembled dewetting...     

New copper(II) complexes produced by the template reaction of acetoacetic-2-pyridylamide and amino-aliphatic alcohols

The template condensation of acetoacetic-2-pyridylamide with amino aliphatic alcohols such as 2-aminoethanol (HL1) and 3-amino propanol (HL2) in the presence of copper(II) ions gave octahedral complexes, which have been characterized by elemental analyses, u.v.-vis. and i.r. spectra, conductivity, d.t.a, magnetic and e.s.r. measurements. The molar conductance in DMF indicate that the complexes are non-ionic in character. The e.s.r. spectra of solid complexes (2) and (5) at room temperature indicate axial type symmetry (dx2-y2) with covalent bond character.     

Interactions of the mitochondrial membrane rat liver D-3-hydroxybutyrate dehydrogenase with glass beads during adsorption chromatography. Relationships with the activation of the enzyme by phospholipids

D-3-Hydroxybutyrate dehydrogenase (BDH) is an NAD(+)-dependent dehydrogenase of the mitochondrial inner membrane involved in the energetic balance between the liver and peripheral organs in mammals. It allows the conversion of ketone bodies (acetoacetate and D-3-hydroxybutyrate) and it is one of the best documented lipid-requiring enzymes with a dependence on lecithins. After release of proteins from the membrane by phospholipase A2 treatment of salt-treated mitochondria, the rat liver enzyme is absorbed on controlled-pore glass beads. After batch washing, the enzyme, devoid of lipids (apoBDH), is specifically eluted at pH 8.05-8.15 with a 0.1 M Tris-1 M LiBr buffer under reducing conditions (5 mM dithiothreitol). It appears that during BDH absorption, the glass beads mimic the phospholipid surface of biomembranes.     

Complex polymer architectures through dimethoxymethyl 1,1‐diphenylethylene derivatives

The reactions of polystyryllithium and potassium on dimethoxymethyl 1,1‐diphenylethylene derivatives were studied in different solvents. In a polar medium, A₃ and A₆ star types were formed according to the stoichiometry, whereas in a nonpolar medium, hyperbranched structures were synthesized. Extensions of an already proposed mechanism in polar and nonpolar media were examined. © 2003 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 41: 3329–3335, 2003     

Oxidative Coupling of Thiols to Disulfides with Ti(IV) in the Presence of NaI under Air Atmosphere

Ti(IV) as TiCl₃(O₃SCF₃) and TiO(O₂CCF₃)₂ are used as efficient catalysts for oxidative coupling of aliphatic, aromatic and heteroaromatic thiols to their disulfides in the presence of NaI under air atmosphere.     

Effect of temperature on IR-absorption of diphenyl

In this work, the temperature dependence of the intensities of the IR absorption bands corresponding to the fundamental vibrations, overtones and combination frequencies of diphenyl is presented. A thorough discussion of the interpretation of the fundamental modes of vibration has been made on the basis of the temperature dependence of the intensities of these absorption bands.The structure of the diphenyl molecule has been the subject of numerous investigations. Despite a considerable amount of work on the Raman(1), IR(3,4,5) and ultraviolet (2) spectra, the assignment of the fundamental frequencies has not yet been established with certainty, Some assistance can be obtained from the temperature dependence of the IR spectrum of this material.     

Kinetics of chlorine isotope exchange reaction between sodium chloride-36 and triphenyltin chloride in mixed solvents

Isotope exchange reaction between NaCl-36 and triphenyltin chloride in dioxane-water (8020% w/w) and ethanol-water (9010% w/w) mixed solvents has been studied at 25, 35 and 50 °C. The exchange reaction was found to proceed via a bimolecular S_N2, limiting mechanism with reaction rates depending on the solvent used. Inhibition of the exchange in ethanol-water is probably due to solvation of chloride ion through hydrogen bond formation. The rate laws for the exchange reactions are: R_e=3.24×10⁹ e^–65550/RT [Rh₃SnCl] [NaCl] in dioxanewater and R_e=6.61×10⁸ e^–69600/RT [Ph₃SnCl] [NaCl] in ethanol-water, where is the degree of dissociation of NaCl and R_e is the rate of exchange in mol l^–1 s^–1. The activation parameters H^*, S^* and G^* are reported.     

Spectrophotometric determination of hydrazines withperi-naphthindan-2,3,4-trione hydrate

Summary A new micromethod for spectrophotometric determination of hydrazine compounds is described. It is based on a reaction withperi-naphthindan-2,3,4-trione hydrate at pH 2.5 to give a red precipitate of dihydroxy-peri-naphthindenone which is dissolved in methanol and measured at 460 nm. The results obtained show an average recovery of 99.8 %, the precision being ± 1 %.

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Zusammenfassung Eine neue Mikromethode zur spektrophotometrischen Bestimmung von Hydrazinverbindungen wurde beschrieben. Sie beruht auf der Reaktion mit peri-Naphthindan-2,3,4-trion-hydrat bei pH 2,5, wobei ein roter Niederschlag von Dihydroxy-peri-naphthindenon entsteht, der in Methanol gelöst und bei 460 nm gemessen wird. 99,8% Substanz werden wiedergefunden, die Genauigkeit beträgt ±1%.