Determination of xanthenone-4-acetic acid in mouse plasma by high-performance liquid chromatography.

Xanthenone-4-acetic acid (XAA) was synthesised during a search for improved analogues of flavone-8-acetic acid, an antitumour agent with a unique mechanism of action but with a number of pharmacological disadvantages. We describe a simple, selective high-performance liquid chromatographic assay suitable for the detection of XAA in mouse plasma. After addition of an internal standard (3-methyl-XAA), plasma was acidified with trichloroacetic acid and extracted with toluene. After evaporation of solvent, samples were chromatographed on a C18 4-microns Novapak cartridge (mobile phase: water-acetonitrile-acetic acid, 65:35:2, v/v) using fluorescence detection. At the maximum tolerated dose of XAA (725 mumol/kg), nonlinear pharmacokinetics were observed.     

UTILIZATION OF TOOLS FOR SUCCESSFUL. TROUBLESHOOTING OF STRUCTURAL PROBLEMS

A structural failure problem was solved using an integrated and iterative program of testing and analysis. The steps taken in solving the problem were: analytical calculations; operational testing; qualifications of analytical results; problem identification; design of corrective action; and confirmatory testing.     

Vortex lattice transitions in YNi2B2C

We have performed extensive small-angle neutron scattering (SANS) diffraction studies of the vortex lattice in single crystal YNi₂B₂C for B‖c. High-resolution SANS, combined with a field-oscillation vortex lattice preparation technique, allows us to separate Bragg scattered intensities from two orthogonal domains and accurately determine the unit cell angle, β. The data suggest that upon increasing field there is a finite transition width where both low- and high-field distorted hexagonal vortex lattice phases, mutually rotated by 45°, coexist. The smooth variation of diffracted intensity from each phase through the transition corresponds to a redistribution of populations between the two types of domains.     

Active noise control in a free field with virtual sensors

The zone of local control around a "virtual energy density sensor" is compared with that offered by an actual energy density sensor, a single microphone, and a virtual microphone. Intended as an introduction to the concept of forward difference prediction and a precursor to evaluating the virtual sensor control algorithms in damped enclosures, this paper investigates an idealized scenario of a single primary sound source in a free-field environment. An analytical model is used to predict the performance of the virtual error sensors and compare their control performance with their physical counterparts. The model is then experimentally validated. The model shows that in general the virtual energy density sensor outperforms the actual energy density sensor, the actual microphone, and the virtual microphone in terms of centering a practically sized zone of local control around an observer who is remotely located from any physical sensors. However, in practice, the virtual sensor algorithms are shown to be sensitive (by varying degrees) to short wavelength spatial pressure variations of the primary and secondary sound fields.     

Flow phenomena in floppy tubes

Collapsible tubes, which occur all over the body, have unique properties from the point of view of both physics and physiology. A brief review is attempted of first the basic observable properties, followed by simple theory to explain the steady-flow aspects and an overview of the somewhat more complex theories for unsteady flow, in particular the flow-induced oscillations. The experimental evidence from laboratory studies is reviewed with particular emphasis on the dynamical system aspects. A final section looks at the current position and prospects.     

Magnetism and superconductivity in ErNi2B2C

We have performed a series of neutron diffraction experiments from the magnetic order and the vortex lattice in single crystal ErNi₂B₂C. The incommensurate magnetic structure develops additional even harmonics below the ‘ferromagnetic’ ordering temperature, T _F of 2.3 K. This feature and the existence of rods of diffuse scattering suggest the development of ferromagnetic microdomain walls. The magnetic structure is very sensitive to the application of a magnetic field with changes in modulation vector and harmonic content. Studies of the vortex lattice show the presence of a 45° reorientation transition and a distorted hexagonal to square transition as a function of applied field. Further distortions of the vortex lattice occur at T _N, but no changes are seen at T _F.