反应型次氯酸荧光探针

生物体内的次氯酸是氯离子和过氧化氢(H₂O₂)由髓过氧化物酶(MPO)催化生成的,是生物体内最重要的活性氧(ROS)之一,在生理过程中发挥了至关重要的作用。但是,过量的次氯酸会导致一系列生理疾病,因此有效的识别和检测次氯酸备受研究者们的青睐。与传统检测方法相比,荧光探针具有选择性好、灵敏度高、可实时监测等诸多优势,因此在近年来得到了快速发展。本文主要基于不同的荧光团,综述了近三年次氯酸荧光探针的研究进展及生物应用。     

方位远探测声波测井仪数据采集控制软件设计*

方位远探测声波测井技术在近年来得到了快速发展,数据采集控制软件是测井仪器系统的重要功能模块,其主要功能是完成地面采集控制平台与井下仪器的实时命令控制与数据传输。方位远探测声波测井仪数据采集控制软件模块以仪器库的形式挂接到成像测井系统,软件主要由仪器初始化、数据采集、数据分析及处理、仪器参数设置、下发命令封装、文件操作、实时波形绘图显示、实时波形处理、数据回放、帮助系统等部分组成。在程序设计中采用了多线程编程技术,提高与测井主控平台进行交互的时效性以及程序的响应速度。实验室及现场测试表明,方位远探测声波测井仪数据采集控制软件的总体及各个功能模块运行稳定,能够完成现场应用过程中对仪器的控制、数据读取、数据分析及处理、文件记录以及与现场测井采集控制平台的数据接口等需求,为仪器的进一步功能优化升级和现场应用提供了基础。     

车-桥系统耦合振动响应的简便计算

依据振动理论推导出了二自由度模型车辆与桥梁系统竖向耦合振动微分方程，采用模态分析的离散化方法，将复杂的偏微分方程问题转化为变系数常微分方程问题，并将微分方程数值积分的Runge-Kutta方法引入到该时变系统的振动响应计算中，使复杂的耦合响应问题得到简便的解决。通过算例验证了该方法的有效性和简便性。该方法只需要直接数值积分，具有公式简单，编程方便，计算速度快等优点，特别适合于工程实际问题的计算，并且不仅适用于匀速运动车辆，也适用于变速运动车辆。     

有限$p$群非正规子群的正规闭包

本文分类了$G/H^G$循环的有限$p$群$G$, 其中$H$为$G$的任意极小非正规子群, $H^G$ 为$H$在$G$中的正规闭包.     

Photonic generation of microwave signals using dual-wavelength single-longitudinal-mode fiber lasers

Photonic generation of microwave signals is demonstrated with a dual-wavelength single-longitudinal-mode erbium-doped fiber ring laser. Microwave signal with a frequency of 21.07 GHz is obtained by aligning the reflection band of a uniform fiber Bragg grating to the two transmission peaks within a fiber Bragg grating-based Fabry-Perot filter. Stable dual-wavelength single-longitudinal-mode operation is guaranteed by means of the combined filtering effect of a saturable absorber and the Fabry-Perot filter. This approach provides an effective solution to the photonic generation of high-frequency microwave signals.     

次谐波聚束器相位控制的算法改进

 为实现次谐波聚束器的数字化相位控制,利用下变频、IQ调制解调技术及商业化的PXI系统,开发了以LabVIEW为平台的低电平控制器。控制器采用了具有自学习和自适应能力的单神经元自适应PID的控制算法,满足了相位稳定度的要求,通过现场测试与传统PID算法进行比较,验证了该算法稳定性好、响应快、抗干扰能力强。     

Pharmacokinetic Study of ZS-1, a Targeted Peptide to NCI-H1299, in Rats Following Intravenous Administration

To investigate the pharmacokinetics of ZS-1 following intravenous injection in rats, ZS-1 was administered at doses of 20, 30 and 45 mg kg^?1, respectively. Blood samples were collected at 0.5, 3, 8, 12, 15, 20, 30, 40 and 45 min. ZS-1 in rat plasma was measured by LC. The limit of detection (LOD) was 0.02 μg mL^?1. The relative standard deviation (RSD) of intra- and inter-day precisions were <10%, and the accuracy of intra- and inter-day were >94%. The mean extraction recovery of ZS-1 was 86.1%. After intravenous injection at doses of 20, 30 and 45 mg kg^?1, the concentration–time curves of ZS-1 fitted well to one compartment model. Area under the concentration–time curves (AUC) increased with dose. Clearance rates (CL) and elimination half-lives (T _1/2) had no significant difference between different dose groups (P > 0.05). ZS-1 was stable in plasma after at 25 °C for 2, 4, 6 h, after three freeze–thaw cycles, after ?20 °C for a month, and after ?80 °C for 3 months. The accuracy of ZS-1 was between 96.8 and 106.9%. The results indicated there was no significant degradation. These data indicated that the method for analysis of ZS-1 was reliable and the pharmacokinetic data could guide dosing regimens to be tested in future clinical pharmacokinetic study.     

Optimizing the spectral efficiency of photonic quantum well structures

One can construct photonic single quantum well structures by sandwiching a homogeneous medium slab as a defect between two symmetrical photonic crystals (PCs). It is shown that the number of observed resonant peaks increases with increasing slab thickness. It is found that while the slab is composed of alternatively stacked step-index films, the frequencies of these resonant peaks can be adjusted finely by changing the film thickness properly. In this case, the frequency and frequency interval of confined states can be tuned accurately, and the spectral efficiency can be greatly enhanced without increasing the volume of optical devices. Numerical simulation is based on the finite-difference time-domain (FDTD) method.     

Temperature and metal composition dependence of lateral photovoltaic effect in Al-Alq3/SiO2/Si structures

A series of Al=-（Alq3）l-x granular films is prepared on Si wafer with native oxide layer using co-evaporation technique. Large lateral photovoltaic effect （LPE） is observed, with an optimal LPV sensitivity of 75 mV/mm in x=0.35 sample. The dependence of LPE on temperature and A1 composition is investigated, and the possible mechanism is discussed.     

木卫停泊轨道间低耗能小推力转移轨道设计方法研究

对木卫停泊轨道间的低耗能小推力转移轨道设计方法进行了研究,提出基于"类halo轨道截面"法的低耗能转移轨道参数化方法和基于配点法的多体Lambert问题求解算法,并利用全局优化算法得出了燃耗最少的初步优化结果;利用多体同伦法和固定近心点高度的多圈转移控制律得到了各段小推力转移轨道的有效设计结果.所提方法同样适用于其他天体间的转移轨道设计,为多体环境下低耗能小推力转移轨道提出了新的设计思路和方法.