Development of the ANN–KIM composed model to predict the nanofluid energetic thermal conductivity via various types of nano-powders dispersed in oil

Journal of Thermal Analysis and Calorimetry - Artificial neural network/kriging interpolation method optimization method which is evaluated concerned the hybrid nanofluid composed of iron oxide...     

Synthesis and structural characterization of [PhE(BNMe2)2]2 (E = P or As): Six-Membered P2B4 and As2B4 Rings with Unusual Structures

The reaction of either Li₂PPh or Li₂AsPh with the diborane(4) derivative B₂(NMe₂)₂Br₂ affords the compounds [PhP(BNMe₂)₂]₂ ( 1 ) or [PhAs(BNMe₂)₂]₂ ( 2 ) in good yield. Both 1 and 2 have cyclic structures featuring non-planar P₂B₄ or As₂B₄ six-membered rings which have chair configurations. Although all four borons in each ring have planar coordination, the two phosphorus or arsenic centers have different degrees of pyramidalization. Bond distances within the rings indicate that the B? B, B? P or B? As bonds are single, whereas the exo-B? N bond lengths are consistent with significant π-bonding. The ring structures of 1 and 2 are in sharp contrast to the related boron-nitrogen species (t-BuN)₂N₄Me₄ which has a nido-N₂B₄ framework. The attempted synthesis of the nitrogen analogue of 1 or 2 by using a similar approach did not result in the isolation of [PhN(BNMe₂)₂]₂, instead the tetramino diborane(4) species [B(NMe₂)NHPh]₂ ( 3 ), which has a structure similar to other tetramine diborane(4) compounds, was isolated.     

Synthesis and Characterization of Novel Monoazo N‐Ester‐1,8‐Naphthalimide Disperse Dyestuffs

Five novel monoazo disperse dyestuffs based on N‐ester‐1,8‐naphthalimide were synthesized. Acenaphthene was nitrated, then oxidized to 4‐nitro‐1,8‐naphthalic anhydride. 4‐Nitro‐1,8‐naphthalic anhydride was reacted with methyl and ethyl glycinate in alcoholic media, followed with reduction. 4‐Amino‐N‐methyl and ethyl glycinate‐1,8‐naphthalimide were obtained. These products were diazotized and coupled with appropriate aromatic amines to give bluish‐red or violet dyestuffs. All intermediates and dyestuffs were purified and characterized by ¹H‐NMR, FTIR, DSC, UV‐VIS and Elemental Analysis. Dispersion of dyestuffs was prepared in water and applied to polyester fabrics. The dyed fabrics showed that four of the synthesized dyestuffs were suitable for coloring polyester fibers, producing deep bluish red with very good build up properties.     

Vector and Cell Line Engineering Technologies Toward Recombinant Protein Expression in Mammalian Cell Lines

The rapid growth of global biopharmaceutical market in the recent years has been a good indication of its significance in biotechnology industry. During a long period of time in recombinant protein production from 1980s, optimizations in both upstream and downstream processes were launched. In this regard, one of the most promising strategies is expression vector engineering technology based on incorporation of DNA opening elements found in the chromatin border regions of vectors as well as targeting gene integration. Along with these approaches, cell line engineering has revealed convenient outcomes in isolating high-producing clones. According to the fact that more than 50% of the approved therapeutic proteins is being manufactured in mammalian cell lines, in this review, we focus on several approaches and developments in vector and cell line engineering technologies in mammalian cell culture.     

Simultaneous formation of platinum‐based nanocatalysts and degradation of dyes at oil/water interface: Comparative morphological and kinetic studies

To decrease the water pollution of textile industries with a large amount of toxic and non‐biodegradable colored dye effluents, an efficient technique is required to safely remove harmful pollutants. In this paper, the reaction between azo dyes and NaBH₄ catalyzed by nanoparticles (NPs) thin films has been studied. We report insitu degradation of methyl orange (MO) and methyl red (MR) by using Pt‐based thin films monitored by UV–Vis spectroscopy. We have synthesized different thin films such as Pt, PtPd, PtFeFe₂O₃, PtNi and PtAu films from Pt organometallic precursor in the MO and MR medium (dye degradation and NPs formation is happened simultaneously) and activity of these films were compared in the complete degradation of MO and MR dyes. Rate constants for the catalyzed reactions have been determined. PtPd NPs thin film has shown the highest rate constant for the degradation of MO and MR within only a few seconds due to its well‐ordered structure. Furthermore, the effect of presence of MO on the morphology of NPs was investigated.     

Global solutions for nonlinear fuzzy fractional integral and integrodifferential equations

This paper is devoted to considering the existence and uniqueness results for fuzzy fractional integral equations employing the method of upper and lower solutions. Moreover, the approach is followed to prove the existence of solutions for the fuzzy initial value problem of fractional integrodifferential equations involving Riemann–Liouville differential operators. The method is illustrated by two examples.     

Highly Efficient Solvent-Free Synthesis of Dihydropyrimidinones Catalyzed by Zinc Oxide

A simple, efficient and practical procedure for the Biginelli reaction using zinc oxid (ZnO) as a novel and reusable catalyst is described under solvent-free conditions in high yields. The use of this agent is characterized by remarkable reactivity, moderate costs, low toxicity and simple work up procedures.     

Analysis of xylene in aqueous media using needle‐trap microextraction with a carbon nanotube sorbent

This paper describes a new extraction technique with needles and a sorbent based on carbon nanotubes to analyze trace amounts of three isomers of xylenes in aqueous samples. In this research, results have been compared with one commercial sorbent. The synthesized sorbent was prepared using sol–gel technology and was packed into 20 gauge needles, and the same size needle was used for packing the commercial sorbent. In the extraction process, a purge and trap sampling methodology is developed, so purging and trapping cycles were performed by a sampling pump. Optimized conditions for standard xylene samples have been obtained, and eight urine samples from workers that were exposed to xylene in the workplace were collected and analyzed. Experimental parameters such as limits of detection and quantification were investigated, and these two parameters were <1 μg/L.     

Investigation of a novel serpentine micromixer based on Dean flow and separation vortices

Meccanica - Passive micromixers, due to their relatively high mixing efficiency and simple fabrication, have wide applications in biological, medical, and chemical processes. Serpentine and...     

Ellagic acid and human cancers: a systems pharmacology and docking study to identify principal hub genes and main mechanisms of action

Research on anticancer properties of natural compounds, as effective materials that are available while causing minimal side effects, is growing. Ellagic acid (EA) is a well-known polyphenolic compound, which has been found in both free and complex modes in several medicinal plants such as pomegranate, walnut, and berries. Although many articles have reported anticancer properties for this compound, its mechanism of action has not been fully elucidated. In this study, we used several online and offline bioinformatics tools and databases to identify the mechanism of action of EA on various types of human malignancies including bladder, blood, breast, cervical, colorectal, liver, pancreas, and prostate cancers. In this context, after identifying and extracting EA-affected human genes/proteins that have been reported in various references, we built the related gene networks and determined functional hub genes. In addition, docking was performed to recognize target proteins that react directly with EA and are in fact most affected by this compound. Our findings revealed that EA exerts its anticancer effects by influencing specific hub genes in various types of cancers. Moreover, different cellular signaling pathways are affected by this natural compound. Generally, it turned out that EA probably exerts most of its anticancer activities, through induction of apoptosis, as well as P53 and WNT signaling pathways, and also by affecting the expression of several hub genes such as CDKN1A, CDK4, CDK2, CDK6, TP53, JUN, CCNA2, MAPK14, CDK1, and CCNB1 and especially interactions with some related proteins including P53, CDK6, and MAPK14.