近红外二区活体荧光成像在肿瘤诊疗中的应用

由于具备组织穿透深度深和时空分辨率高等优势, 近年来近红外二区(Near-infrared-Ⅱ, NIR-Ⅱ, 1000~1700 nm)荧光成像技术得到了快速发展, 其在肿瘤临床诊断和治疗的潜力更是引发了广泛关注. 本文首先阐释了NIR-Ⅱ窗口荧光成像的原理及其优势, 随后根据结构分类归纳总结了现有荧光团的特征, 重点介绍了荧光探针在性能优化上的进展以及在肿瘤早期检测、 术中导航和光疗中的应用, 最后讨论了现有NIR-Ⅱ 荧光探针的局限以及临床转化面临的挑战, 并对未来的发展方向进行了展望.     

Photonic generation of arbitrary waveforms based on incoherent wavelength-to-time mapping

We demonstrate experimentally a radio frequency arbitrary waveform generator using the incoherent wavelengthto-time mapping technique.The system is implemented by amplitude modulation of a broadband optical resource whose spectrum is reshaped by a programmable optical pulse shaper and transmitted over a single mode fiber link.The shape of the generated waveform is controlled by the optical pulse shaper,and the fiber link introduces a certain group velocity delay to implement wavelength-to-time mapping.Assisted by the flexible optical pulse shaper,we obtain different shapes of optical waveforms,such as rectangle,triangle,and sawtooth waveforms.Furthermore,we also demonstrate ultra-wideband generation,such as Gaussian monocycle,doublet,and triplet waveforms,using the incoherent technique.     

基于相位调制和线性滤波的多信道多功能光学微分器

多功能微分器可以满足光计算和光信号处理中的多种需求, 增强灵活性. 本文从理论上推导了一种基于相位调制和线性滤波的多功能光学微分器. 并在实验中, 将传输谱线近似为线性的光纤延时干涉仪(DI)和相位调制器级联, 得到了输入信号的两种微分结果. 通过调节DI的驱动电压调节其传输谱的漂移, 当光载波位于DI的传输谱线的谷值, 则获得信号的光场微分, 当光载波位于DI传输谱的线性斜率处, 则得到输入信号的光强微分. 通过分析各种微分的平均误差, 发现DI的线性度越高, 平均误差越小. 同时基于DI传输谱线的梳状特性,证实了多信道信号的同时微分.     

Photonic multi-shape UWB pulse generation using a semiconductor optical amplifier-based nonlinear optical loop mirror

We propose and demonstrate a scheme to implement photonic multi-shape ultra-wideband(UWB) signal generation using a semiconductor optical amplifier(SOA) based nonlinear optical loop mirror(NOLM).By employing the cross phase modulation(XPM) effect,cross gain modulation(XGM),or both,multi-shape UWB waveforms are generated including monocycle,doublet,triplet,and quadruplet pulses.Both the shapes and polarities of the generated pulses are flexible to adjust,which may be very useful in UWB pulse shape modulation and pulse polarity modulation.     

Photonic generation of power-efficient FCC-compliant ultra-wideband waveforms using semiconductor optical amplifier （SOA）： theoretical analysis and experiment verification

We theoretically design a power-efficient ultra-wideband pulse generator by combining three monocycle pulses with different weights. We also experimentally demonstrate a feasible scheme to generate such power-efficient ultra-wideband waveforms using cross-phase modulation in a single semiconductor optical amplifier. The designed ultra-wideband pulse fully satisfies the requirements for the spectral mask specified by the Federal Communications Commission with high power efficiency. In the experiment, a power-efficient ultra-wideband waveform with a pulse duration of 310 ps is achieved, and the power efficiency is greatly improved compared with that of a single monocycle pulse or a mixture of two monocycles.