Synthesis,Crystal Structure and Evaluations of Its Cytotoxicity,Anti-microbial and Anti-hydroxyl Radical Activities of a New Co-crystal Compound(C_6H_6Cl_2N_2O_2S)·(Phen)·H_2O

Co-crystal is a very potential kind of drug solid forms, and has a far-reaching influence on designing and preparing drugs. A new 1:1:1 co-crystal compound consisting of 4-amino-3,5-dichloro-benzenesulfonamide, 1,10-phenanthroline and water was synthesized, and its crystal structure was characterized by X-ray diffraction method. The compositions of the co-crystal are self-assembled into a three-dimensional network structure via intermolecular interactions including hydrogen bonds, π-π stacking, Cl???Cl interactions and van der Waals' forces. According to the evaluations of cytotoxicity assays, anti-microbial and anti-hydroxyl radicals, this co-crystal is a potential drug.     

一个共配的铜基配合物的合成、晶体结构及抗肿瘤活性

合成了一个以N-{[2-羟基-4-甲氧基苯基\]甲亚胺}苯丙氨酸阴离子和2,2′-联吡啶共配位的铜基配合物[Cu(C₁₇H₁₅NO₄)(C₁₀H₈N₂)]₂•CH₃OH（1）,其结构经IR、 元素分析、X-射线单晶衍射及Hirshfeld表面分析表征。用MTT法考察了配合物对耐顺铂的人肺癌细胞株（A549/DDP,DDP=顺铂）和人宫颈癌细胞株（C33A）的细胞毒性,用流式细胞术分析了配合物〖STHZ〗1〖STBZ〗诱导A549/DDP细胞凋亡和线粒体膜电位下降,初步考察了配合物1的抗肿瘤活性。结果表明：配合物1（CCDC:1913991）属于三斜晶系,Pī空间群,晶体学参数为：a = 10.1770(5) Å, b, c, α = 104.576(4)°,β = 101.151 (4)°,γ = 101.151(4)°,V = 1197.71(11) ų, Z =1,R₁ = 0.0344, wR₂,S = 1.061a = 10.1770(5) Å, b = 10.2030(5) Å, c = 12.5857(6) Å, α = 104.576(4)°,β = 101.151 (4)°,γ = 101.151(4)°,V = 1197.71(11) ų, Z =1,R₁ = 0.0344, wR₂ = 0.0913,S = 1.061;配合物1对肿瘤细胞有显著细胞毒性,对A549/DDP和C33A细胞作用24 h后,IC₅₀值分别为(9.75±0.39) μmol·L^-1和(28.13±1.27) μmol·L^-1;其通过诱导A549/DDP细胞的线粒体膜电位下降而导致细胞凋亡,配合物1浓度为40.0 μmol·L^-1时,与A549/DDP细胞孵育36 h,诱导A549/DDP细胞总凋亡率为41.0%,与A549/DDP细胞孵育30 h,使A549/DDP细胞的线粒体膜电位降低了47.4%。 = 0.0913 = 12.5857(6) Å = 10.2030(5) Å     

连续变焦的聚合物分散液晶电控透镜

介绍了一种基于聚合物分散液晶材料的连续调焦电控透镜.在聚合物分散液晶盒的上表面电极上刻蚀圆孔,形成一个非对称电极,在液晶盒上下极板之间,诱发一个非均匀电场,从而引起聚合物分散液晶材料的折射率非均匀分布,形成电控变焦透镜.阐述了聚合物分散液晶可调焦透镜的基本原理,分析了透镜孔径对聚合物分散液晶透镜焦距的影响,在直径3mm和6mm的圆孔条件下,分别测量了透镜焦距随电压的变化关系.结果表明:电压从50V加到170V的过程中,透镜焦距逐渐减短,刻蚀3mm圆孔的聚合物分散液晶盒焦距从1.361 63m到0.429 21m,刻蚀6mm圆孔的聚合物分散液晶盒焦距从1.769 92m到0.548 43m.     

微波促进合成苝单酰亚胺类化合物

以3,4;9,10-苝四甲酸酐为原料,经微波促进反应探讨了反应底物用量、反应时间和反应温度等条件对反应收率的影响,合成了系列苝单酰亚胺类化合物,其中2,6-二异丙基苯胺修饰的苝单酰亚胺化合物N-2’,6’-二异丙基苯胺基-3,4-苝单酰亚胺(PMI-1)在30min的反应时间内,分离收率可达64.1%.