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1.
Kentarou Sakamoto Dr. Misao Akishiba Takahiro Iwata Dr. Kazuya Murata Dr. Seiya Mizuno Dr. Kenichi Kawano Dr. Miki Imanishi Prof. Dr. Fumihiro Sugiyama Prof. Dr. Shiroh Futaki 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(45):20165-20173
Endocytic pathways are practical routes for the intracellular delivery of biomacromolecules. Along with this, effective strategies for endosomal cargo release into the cytosol are desired to achieve successful delivery. Focusing on compositional differences between the cell and endosomal membranes and the pH decrease within endosomes, we designed the lipid-sensitive and pH-responsive endosome-lytic peptide HAad. This peptide contains aminoadipic acid (Aad) residues, which serve as a safety catch for preferential permeabilization of endosomal membranes over cell membranes, and His-to-Ala substitutions enhance the endosomolytic activity. The ability of HAad to destabilize endosomal membranes was supported by model studies using large unilamellar vesicles (LUVs) and by increased intracellular delivery of biomacromolecules (including antibodies) into live cells. Cerebral ventricle injection of Cre recombinase with HAad led to Cre/loxP recombination in a mouse model, thus demonstrating potential applicability of HAad in vivo. 相似文献
2.
Dr. Ayumi Hirano‐Iwata Yutaka Ishinari Dr. Hideaki Yamamoto Prof. Michio Niwano 《化学:亚洲杂志》2015,10(6):1266-1274
Ion channel proteins provide gated pores that allow ions to passively flow across cell membranes. Owing to their crucial roles in regulating transmembrane ion flow, ion channel proteins have attracted the attention of pharmaceutical investigators as drug targets for use in the studies of both therapeutics and side effects. In this review, we discuss the current technologies that are used in the formation of ion channel‐integrated bilayer lipid membranes (BLMs) in microfabricated devices as a potential platform for next‐generation drug screening systems. Advances in BLM fabrication methodology have allowed the preparation of BLMs in sophisticated formats, such as microfluidic, automated, and/or array systems, which can be combined with channel current recordings. A much more critical step is the integration of the target channels into BLMs. Current technologies for the functional reconstitution of ion channel proteins are presented and discussed. Finally, the remaining issues of the BLM‐based methods for recording ion channel activities and their potential applications as drug screening systems are discussed. 相似文献
3.
动态核极化法(Dynamic Nuclear Polarization, DNP)是利用热平衡下的电子在磁场中的高自旋极化率转移到原子核自旋的技术,从而极大的提高原子核自旋极化率。多种动态极化靶材料已广泛的用于自旋物理散射实验。本文介绍一种简单实用,共同开发的日本山形大学DNP系统,包括超导磁场,氦4蒸发恒冷器,微波系统以及NMR核磁共振检测系统,测得中子靶材料氘带丁醇(D-butanol)中氘核的极化率在2.5T/1.3K达到+6.5%。 相似文献
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Keitaro Tanoi Natsuko I. Kobayashi Takayuki Saito Naoko Iwata Atsushi Hirose Yoshimi Ohmae Ren Iwata Hisashi Suzuki Tomoko M. Nakanishi 《Journal of Radioanalytical and Nuclear Chemistry》2013,296(2):749-751
The time course of Mg uptake and release using intact rice plants and 28Mg as a tracer is presented. Since there is no conventional Mg tracer available, 28Mg was produced via 27Al(α, 3p)28Mg reaction using a cyclotron. Using the purified 28Mg tracer, it was found that the uptake amount of 28Mg by the rice plants increased linearly during 30 min of application. After 28Mg treatment for 90 min, the roots were sequentially washed with iced solution for 120 min. Within about 10 min, almost all of the 28Mg, that was thought to be weakly bound to the apoplast, was washed away. 相似文献
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This study investigates the recovery of electric resistivity in pure iron, Fe–0.6Ni and Fe–1.5Mn as related to isochronal annealing following 1 MeV proton irradiation at lower temperature than 70 K, focusing on the relationship between solute atoms and irradiation defects. Both nickel and manganese prevent stage ID recovery, which corresponds to correlated recombination. Stage II recovery is also changed by the addition of a solute, which corresponds to the migration of small interstitial clusters. In both pure iron and Fe–0.6Ni, no evident difference was observed in the stage III region, which corresponds to the migration of vacancies. In contrast, two substages appeared in the Fe–1.5Mn at a higher temperature than stage IIIB appeared in pure iron. These substages are considered to represent the release of irradiation-induced defects, which was trapped by manganese. 相似文献
9.
The catalytic activities of the cationic synthetic flavin adduct 1 with various dendritic and non-dendritic 2,6-bis(acylamino)pyridines 2 were examined for the oxidation of organic sulfides with H2O2. The adduct of 5-ethyllumiflavinium perchlorate 1a with 2b–d bearing poly(benzyl ether) dendron units acts as an efficient organocatalyst for the oxidative transformation of sulfides to the corresponding sulfoxides under mild conditions. 相似文献
10.
Dr. M. Tanaka Prof. Dr. M. Hamada Prof. Dr. Y. Iwata 《Archive of Applied Mechanics (Ingenieur Archiv)》1982,52(1-2):95-104
Summary This paper presents a boundary element formulation for elastostatic problems. The formulation is expressed in terms of the matrix notation, so that it is easily applicable to an available system of matrix structural analysis. A computer program developed is used to calculate the stress intensity factor K
I for some example problems in plane elasticity. Comparison is made between the boundary element calculations and other solutions, whereby the effectiveness of the boundary element method is demonstrated.
Berechnung eines zweidimensionalen Spannungsintensitätsfaktors mit der Methode der Bandelemente
Übersicht Dieser Aufsatz bietet eine Formulierung elastostatischer Probleme durch die Methode der Randelemente an. Die Formulierung benutzt eine Darstellung in Matrizenbezeichnung, so daß sie auf ein verfügbares System für Matrizenstrukturberechnung einfach anwendbar ist. Ein ausgebautes Computerprogramm wird auf die Berechnung des Spannungsintensitätsfaktors K i für einige Beispiele in der ebenen Elastizität angewendet. Die mittels der Randelemente erhaltenen Ergebnisse werden mit anderen Lösungen verglichen. Dadurch zeigt sich die Wirksamkeit der Methode der Randelemente.相似文献