Destabilizing the interplay between miR-1275 and IGF2BPs by Tamarix articulata and quercetin in hepatocellular carcinoma

Insulin-like growth factor-2 binding proteins (IGF2BPs) are oncogenic RNA-binding proteins, highly up-regulated in HCC, and were recently validated as direct targets of the tumour suppressor miR-1275. It is worth noting that around 47% of FDA approved anticancer drugs are derived from plants. Modulation by miRNAs and their cellular signalling cascades could constitute new pathways by which these phytochemicals exert their effects. This study aimed to investigate the potential use of Tamarix articulata, quercetin and epigallocatechin gallate (EGCG) in HCC and how these phytochemicals could epigenetically modulate the IGF axis using their impact on miR-1275. T. articulata ethyl acetate fraction significantly reduced the viability of Huh-7 cells compared to control cells. Treatment with T. articulata ethyl acetate fraction, quercetin and EGCG significantly enhanced miR-1275, while suppressed IGF2BP1 and IGF2BP3 mRNA expression levels. In summary, T. articulata, quercetin and EGCG have important implications for HCC molecular-targeted therapy through destabilizing the interplay between miR-1275 and the IGF axis.     

Ionic liquid behavior and high thermal stability of silver chloride nanoparticles: Synthesis and characterization

Silver chloride was found to be stable even after calcination at 650 °C for 10 h. SEM studies revealed the morphology of silver chloride as hexagonal particles. TEM studies show the size of silver chloride particles to have an average size of 6–7 nm. Thermal studies suggest that silver chloride nanoparticles behave like ionic liquid or molten salt in the range of 455–650 °C.     

Efficient aerial oxidation of different types of alcohols using ZnO nanoparticle–MnCO3-graphene oxide composites

Graphene–metal nanocomposites have been found to remarkably enhance the catalytic performance of metal nanoparticle-based catalysts. In continuation of our previous report, in which highly reduced graphene oxide (HRG)-based nanocomposites were synthesized and evaluated, we present nanocomposites of graphene oxide (GRO) and ZnO nanoparticle-doped MnCO₃ ([ZnO–MnCO₃/(1%)GRO]) synthesized via a facile, straightforward co-precipitation technique. Interestingly, it was noticed that the incorporation of GRO in the catalytic system could noticeably improve the catalytic efficiency compared to a catalyst (ZnO–MnCO₃) without GRO, for aerial oxidation of benzyl alcohol (BzOH) employing O₂ as a nature-friendly oxidant under base-free conditions. The impacts of various reaction factors were thoroughly explored to optimize reaction conditions using oxidation of BzOH to benzaldehyde (BzH) as a model substrate. The catalysts were characterized using X-ray diffraction, thermogravimetric analysis, Fourier transform infrared spectroscopy, field-emission scanning electron microscopy, Energy dispersive X-ray spectroscopy (EDX), Brunauer-Emmett-Teller (BET), and Raman spectroscopy. The (1%)ZnO–MnCO₃/(1%)GRO exhibited significant specific activity (67 mmol.g⁻¹.hr⁻¹) with full convversion of BzOH and >99% BzH selectivity within just 6 min. The catalytic efficiency of the (1%)ZnO–MnCO₃/(1%)GRO nanocomposite was significantly better than the (1%)ZnO–MnCO₃/(1%)HRG and (1%)ZnO–MnCO₃ catalysts, presumably due to the existence of oxygen-possessing groups on the GRO surface and as well as a very high surface area that could have been instrumental in uniformly dispersing the active sites of the catalyst, i.e., ZnO–MnCO₃. Under optimum circumstances, various kinds of alcohols were selectively transformed to respective carbonyls with full convertibility over the (1%)ZnO–MnCO₃/(1%)GRO catalyst. Furthermore, the highly effective (1%)ZnO–MnCO₃/(1%)GRO catalyst could be successfully reused and recycled over five consecutive runs with a marginal reduction in its performance and selectivity.     

A methoxylated quercetin glycoside harnesses HCC tumor progression in a TP53/miR-15/miR-16 dependent manner

Abstract

This study focused on studying the impact of flavonoids isolated from Cleome droserifolia on HCC cell lines and to further unveil their possible impact on TP53 and its downstream tumor suppressor miRNAs. Three flavonol glycosides were isolated from C. droserifolia namely, Isorhamnetin-3-O-β-D-glucoside (1), Quercetin-3`-methoxy-3-O-(4``-acetylrhamnoside)-7-O-α-rhamnoside (2), and Kaempferol-4`-methoxy-3,7-O-dirhamnoside (3). They showed a concentration and time dependent reduction in cellular viability and anchorage-independent growth of HCC cells. Moreover, they exhibited a decrease in the migrating capacity of HepG2 cells in a pattern similar to positive control cells. (2) Showed the most potent effects in halting HCC tumorigenic activity (IC₅₀=36?±?1.70?µM) and a repression of the cellular proliferation rate of HepG2 cells. Restoration of TP53 and its downstream tumor suppressor miRNAs; miR-15a, miR-16, miR-34a by (2) was observed. Moreover, attenuation of (2) mediated actions was shown upon using anti-miR-15a and anti-miR-16. To conclude, this study crystallizes a novel role of C. droserifolia in harnessing HCC progression in-vitro with a possible contribution of TP53/miR-15a/miR-16.     

An Improved Hardy's Inequality

In this paper we shall extend Hardy's inequality associated with Fourier transform to the strip n(2-p) ≤ σ < n+p(N +1) where N = [n(1/p-1)], the greatest integer not exceeding n(1/p−1).     

New ring of a class of Bessel integral operators

In this paper, we introduce a new ring of ponderation functions which allowed us to describe and classify a large class of ring of Bessel integral operators. The main result is to give an explicit form of some ideals of such a ring of operators.     

Maximal function on the dual of Laguerre hypergroup

In this paper, we are interested in the Laguerre hypergroup $\mathbb{K} = [0,\infty ) \times \mathbb{R}$ which is the fundamental manifold of the radial function space for the Heisenberg group. So, we consider the generalized shift operator generated by the dual of the Laguerre hypergroup which can be topologically identified with the so-called Heisenberg fan, the subset of ?²: $$\bigcup\limits_{j \in \mathbb{N}} {\left\{ {(\lambda ,\mu ) \in \mathbb{R}^2 :\mu = \left| \lambda \right|(2j + \alpha + 1),\lambda \ne 0} \right\} \cup \left\{ {(0,\mu ) \in \mathbb{R}^2 :\mu \geqslant 0} \right\}} ,$$ by means of which the maximal function is investigated. For 1 < p ?? ??, the L _p ( )-boundedness and weak L ₁( )-boundedness result for the maximal function is obtained.     

Hardy’s Inequality for the n-Dimensional Hankel Transform

Analysis Mathematica - The purpose of this paper is to prove a Hardy type inequality associated with the n-dimensional Hankel transform (n ≥ 1) for the exponent σ0 = n(2 ? p) +...     

Pseudo-differential operators associated with Laguerre hypergroups

In this paper we consider the generalized shift operator generated from the Laguerre hypergroup; by means of this, pseudo-differential operators are investigated and Sobolev-boundedness results are obtained.     

Sobolev Type Spaces on the Dual of the Laguerre Hypergroup

Sobolev type spaces E ^s,p (0, sR, p[1,+]) are defined on R×N by using the Fourier transform and its inverse on the Laguerre hypergroup. An analogue of H ^s (R ⁿ ), denoted by H ^s is investigated in this paper. Some properties including completeness and imbedding results for these spaces are given, Reillich-type theorem and Poincaré's inequality are proved. Also, global regularity results for certain differential operators are obtained.