The cathodic cleavage of aromatic sulphonamides: an elegant way to produce amino radicals themselves fully characterized by means of the spin marking technique

Sulphonamides may lead, in the course of their cathodic cleavage, to intermediate amino radicals. These radicals may be reduced or trapped rapidly by nitrones added “ in situ ”. The method allows (by means of ESR spectral analysis) elements for establishing cleavage mechanisms to be obtained.     

In vitro anticancer activity of binuclear Ru(II) complexes with Schiff bases derived from 5-substituted salicylaldehyde and 2-aminopyridine with notably low IC50 values

The binuclear Ru(II) complexes with Schiff bases derived from 5-chlorosalicyladehyde and 2-aminopyridine and its 5-substituted salicylideneimine homologues were tested in vitro against cervical carcinoma (HeLa), metastatic colorectal adenocarcinoma (SW620), lung adenocarcinoma (A549), breast adenocarcinoma (MCF-7), and human lung fibroblast (WI-38) cell lines. All compounds showed strong antiproliferative activity with extremely low IC₅₀ values. The compounds expressed strong activity against gram-positive bacteria, Staphylococcus aureus and Enterococcus faecalis.     

Planning and approximation models for delivery route based services with price-sensitive demands

Classical vehicle routing problems typically do not consider the impact of delivery price on the demand for delivery services. Existing models seek the minimum sum of tour lengths in order to serve the demands of a given set of customers. This paper proposes approximation models to estimate the impacts of price on delivery services when demand for delivery service is price dependent. Such models can serve as useful tools in the planning phase for delivery service providers and can assist in understanding the economics of delivery services. These models seek to maximize profit from delivery service, where price determines demand for deliveries as well as the total revenue generated by satisfying demand. We consider a variant of the model in which each customer’s delivery volume is price sensitive, as well as the case in which customer delivery volumes are fixed, but the total number of customers who select the delivery service provider is price sensitive. A third model variant allows the delivery service provider to select a subset of delivery requests at the offered price in order to maximize profit.     

Commutativity of first‐order discrete‐time linear time‐varying systems

After introducing the concept of commutativity for continuous‐time linear time‐varying systems, the related literature and the results obtained so far are presented. For a simple introduction of the commutativity of discrete‐time linear time‐varying systems, the problem is formulated for first‐order systems. Finally, explicit necessary and sufficient conditions for the commutativity of first‐order discrete‐time linear time‐varying systems are derived, and their advantageous use in digital system design is illustrated, which are the main objectives of the paper. The results are verified by examples which include an application in amplitude modulation for digital telecommunication.     

Magallanesine: an isoindolobenzazocine alkaloid

$\text{Berberis darwinii}$ Hook.(Berberidaceae) has yielded magallanesine ($\text{1}$), the first known isoindolobetizazocine alkaloid.     

Critical swelling of particle-encapsulating vesicles

We consider a ubiquitous scenario where a fluctuating, semipermeable vesicle is embedded in solution while enclosing a fixed number of solute particles. The swelling with increasing number of particles or decreasing concentration of the outer solution exhibits a continuous phase transition from a fluctuating state to the maximum-volume configuration, whereupon appreciable pressure difference and surface tension build up. This criticality is unique to particle-encapsulating vesicles, whose volume and inner pressure both fluctuate. It implies a universal swelling behavior of such vesicles as they approach their limiting volume and osmotic lysis.     

Micron-scale origin of the shear-induced structure in Laponite–poly(ethylene oxide) dispersions

We study the transient response to simple shear of aqueous dispersions of Laponite clay particles and poly(ethylene oxide) at concentrations for which shear induces structure in the form of a network of polymer–clay bonds. We examine the effects of shear on the structure at the micrometer length scale. Bulk rheometric measurements give the material’s response to step changes in shear rate. We find that a critical value of the shear rate separates two regions with different rheological behaviors. Static small-angle light scattering shows a corresponding qualitative change in the anisotropy of the dispersion under shear at the micron scale. We interpret our results in terms of the effects of shear on the interactions between clay particles and polymer chains and on the aggregation mechanisms in the dispersion.     

RNA-sensitive N-isopropylacrylamide/vinylphenylboronic acid random copolymer

Random copolymers of N-isopropylacrylamide (NIPA) and 4-vinylphenylboronic acid (VPBA) were obtained by solution polymerization using 2,2′-azobisizobutyronitrile as the initiator in ethanol at 65 °C. NIPA-co-VPBA copolymer exhibited both temperature- and pH-sensitivity. Thermally reversible phase transitions were observed both in the acidic and alkaline pH region for the copolymers produced with different VPBA/NIPA feed ratios. The pH dependency of the lower critical solution temperature (LCST) was stronger for the copolymers produced with higher VPBA feed concentrations. RNA was selected as a model biomolecule having vicinal-diol and amino groups that were potentially reactive with the boronic acid groups of NIPA-co-VPBA copolymer. The effect of RNA concentration on the LCST of NIPA-co-VPBA copolymer was investigated in aqueous media at different pHs. Although no significant effect was observed at pH 4, 7 or 10.5, the LCST decreased linearly with increasing RNA concentration at a pH approximately equal to the pK_a of boronic acid. This behavior was explained by considering the binding of RNA onto the copolymer chains to occur via two types of complex formation. For the formation of these complexes, the amino and vicinal-diol groups of RNA should react with the boronic acid groups of the copolymer in the tetrahedral anionic form. The results indicated that NIPA-co-VPBA copolymer could be utilized as a new reagent for the determination of RNA concentration in aqueous media. The proposed method was valid for the RNA concentration range of 0–4 g · mL⁻¹.

The schematical representation of the possible interactions between NIPA-co-VPBA copolymer and RNA. (A) A typical structure of single-stranded RNA. (B) Tetrahedral anionic form of boronic acid groups. (C) The interaction between the amino groups of the unpaired bases of RNA and the boronic acid groups of the copolymer. (D) Cyclic borate ester formation by the interaction between vicinal diol groups located at the 3′-end of RNA and boronic acid groups of the copolymer.     

(±)-Nuevamine,an isoindoloisoquinoline alkaloid,and (±)-lennoxamine,an isoindolobenzazepine

$\text{Berberis darwinii}$ Hook (Berberidaceae) has yielded the lactams (±)-nuevamine (7) and (±)-lennoxamine (8). Nuevamine is the first known isoindoloisoquinoline alkaloid, while lennoxamine is an isoindolobenzazepine structurally related to (±)-chilenine (3).