STUDIES OF MELNIKOV METHOD AND TRANSVERSAL HOMOCLINIC ORBITS IN THE CIRCULAR PLANAR RESTRICTED THREE－BODY PROBLEM

ＳＴＵＤＩＥＳ　ＯＦ　ＭＥＬＮＩＫＯＶ　ＭＥＴＨＯＤ　ＡＮＤ　ＴＲＡＮＳＶＥＲＳＡＬ　ＨＯＭＯＣＬＩＮＩＣ　ＯＲＢＩＴＳ　ＩＮ　ＴＨＥ　ＣＩＲＣＵＬＡＲ　ＰＬＡＮＡＲ　ＲＥＳＴＲＩＣＴＥＤ　ＴＨＲＥＥ－ＢＯＤＹ　ＰＲＯＢＬＥＭＺｈｕＲｕｚｅｎｇ（朱如...     

变量的两种独立性和哈密顿原理的无穷多样性

变量的两种独立性和哈密顿原理的无穷多样性朱如曾，向程（中国科学院力学研究所，北京１０００８０）最近《力学与实践》发表了“对广义动量的探讨”一文￣［１２］，该文批评了９本力学著作￣［１－２，４－１０］的有关论述￣１）．如果文［１２］的批评是正确的，那么...     

Melnikov方法和圆型平面限制性三体问题的横截同宿研究*

本文对由两自由度近可积哈密顿系统经非正则变换而得到的,具有高阶不动点的非哈密顿系统给出了判别横截同宿轨和横截异宿轨存在性的两条判据。对原二体质量比很小时近可积圆型平面限制性三体问题,采用本文判据证明存在横截同宿轨,从而存在横截同宿穿插现象;还在一定假设下证明了存在横截异宿轨;并给出了全局定性相图。     

A mathematical model for ATP-mediated calcium dynamics in vascular endothelial cells induced by fluid shear stress

In consideration of the mechanism for shear-stress-induced Ca^2＋ influx via ATP（adenosine triphosphate）-gated ion channel P2X4 in vascular endothelial cells, a modified model is proposed to describe the shear-stress-induced Ca^2＋ influx. It is affected both by the Ca^2＋ gradient across the cell membrane and extracellular ATP concentration on the cell surface. Meanwhile, a new static ATP release model is constructed by using published experimental data. Combining the modified intracellular calcium dynamics model with the new ATP release model, we establish a nonlinear Ca^2＋ dynamic system in vascular endothelial cells. The ATP-mediated calcium response in vascular endothelial cells subjected to shear stresses is analyzed by solving the governing equations of the integrated dynamic system. Numerical results show that the shear-stress-induced calcium response predicted by the proposed model is more consistent with the experimental observations than that predicted by existing models.     

一种剪应力作用下ATP调节的血管内皮细胞内钙离子动力学数学模型

考虑剪应力诱导血管内皮细胞钙离子内流主要取决于经由三磷酸腺苷（ATP）门控离子通道P2X4的钙离子内流这一实验事实,提出一个修正的剪应力诱导钙离子内流模型,认为钙离子内流量不仅取决于细胞膜内外钙离子浓度差,而且受细胞表面ATP浓度调节A·D2同时利用文献中公布的实验结果,建立了一个新的静态ATP分泌模型,并将其整合到修正后的钙离子内流模型中,建立了一个描述动脉内皮细胞内非线性钙离子动力学系统．求解整合后动力学系统的控制方程,可获得内皮细胞在剪应力作用下受ATP调节的钙离子响应．结果表明,与文献中其他模型比较,改进后的模型模拟的结果能更真实地反映实验事实．