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Annika Höhn Petra Hartmann Veronika Gebhart Johanna Sonntag Tilman Grune Tobias Jung 《Photochemistry and photobiology》2015,91(4):887-894
In this study, the athermal effects of water‐filtered infrared A (wIRA)‐irradiation (780–1400 nm) on human dermal fibroblasts were investigated. For this purpose, cells were exposed to wIRA‐irradiation (178 mW cm?2 for 1 h), while a sophisticated experimental setup prevented warming of the samples exceeding 0.1°C. The investigated parameters were the formation of reactive oxygen species (ROS), mitochondrial membrane potential and superoxide release, protein oxidation, proliferation rate, as well as intracellular Ca2+‐release in single cells, most of them quantified via fluorescence microscopy and fluorimetric techniques. The existence of actual athermal wIRA‐effects is still intensively discussed, since their detection requires a careful experimental setup and both efficient and powerful temperature regulation of the exposed samples. Here, we can definitively show that some of the supposed athermal wIRA‐effects may be rather artifacts, since wIRA did not reveal any impact on the above mentioned parameters—as long as the temperature of the exposed cells was carefully maintained. Though, we were able to identify an athermal DNA‐protective wIRA‐effect, since the induced DNA damage (quantified via 8‐Oxo‐G‐formation) was significantly decreased after a subsequent UVB‐exposure. These results suggest that many of the supposed athermal wIRA‐effects can be induced by pure warming of the samples, independent from any wIRA‐irradiation. 相似文献
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The European Physical Journal H - The Einstein Archives contain a considerable collection of calculations in the form of working sheets and scratch paper, documenting Einstein’s scientific... 相似文献
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Tilman Krauch Bernd Schweizer 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-2):207-209
Abstract Through a direct and selective deprotection of 1 (R=methyl) with boron tribromide substituted o-hydroxy-dithiophosphinic acid 1 was prepared under mild conditions in excellent yield. 相似文献
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Agrobacterium fabrum is a widely used model bacterium for gene transfer from pro‐ to eukaryote, for genetics and metabolism. The phytochrome system of Agrobacterium, encompassing the two phytochromes Agp1 and Agp2, has provided deep insight into phytochrome action in a bacterial organism. This review summarizes recent results on phytochrome evolution, phytochrome regulation of conjugation and plant infection and biochemical studies including the crystal structure of Agp1‐PCM, the photosensory core module of Agp1. 相似文献
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Crystal Structures of Bacterial (6‐4) Photolyase Mutants with Impaired DNA Repair Activity 下载免费PDF全文
Kalinga Bowatte Dennis Kwiatkowski Esther Mittmann Heba Qasem Norbert Krauß Xiaoli Zeng Zhong Ren Patrick Scheerer Xiaojing Yang Tilman Lamparter 《Photochemistry and photobiology》2017,93(1):304-314
PhrB from Agrobacterium fabrum is the first prokaryotic photolyase which repairs (6‐4) UV DNA photoproducts. The protein harbors three cofactors: the enzymatically active FAD chromophore, a second chromophore, 6,7‐dimethyl‐8‐ribityllumazine (DMRL) and a cubane‐type Fe‐S cluster. Tyr424 of PhrB is part of the DNA‐binding site and could provide an electron link to the Fe‐S cluster. The PhrBY424F mutant showed reduced binding of lesion DNA and loss of DNA repair. The mutant PhrBI51W is characterized by the loss of the DMRL chromophore, reduced photoreduction and reduced DNA repair capacity. We have determined the crystal structures of both mutants and found that both mutations only affect local protein environments, whereas the overall fold remained unchanged. The crystal structure of PhrBY424F revealed a water network extending to His366, which are part of the lesion‐binding site. The crystal structure of PhrBI51W shows how the bulky Trp leads to structural rearrangements in the DMRL chromophore pocket. Spectral characterizations of PhrBI51W suggest that DMRL serves as an antenna chromophore for photoreduction and DNA repair in the wild type. The energy transfer from DMRL to FAD could represent a phylogenetically ancient process. 相似文献
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Christoph Englert Tilman PlehnMichael Rauch Dirk ZerwasPeter M. Zerwas 《Physics letters. [Part B]》2012,707(5):512-516
Interpretations of Higgs searches critically involve production cross sections and decay probabilities for different analysis channels. Mixing effects can reduce production rates, while invisible decays can reduce decay probabilities. Both effects may transparently be quantified in Higgs systems where a visible Higgs boson is mixed with a hidden sector Higgs boson. Recent experimental exclusion bounds can be re-interpreted in this context as a sign for non-standard Higgs properties. Should a light Higgs boson be discovered, then our analysis will quantify how closely it may coincide with the Standard Model. 相似文献
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S. W. Johnsohn E. H. Jenkins Max Gruber Gassend Quantin Stromeyer und C. Krauch 《Fresenius' Journal of Analytical Chemistry》1882,21(1):274-279
Ohne Zusammenfassung 相似文献
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J. König und C. Krauch 《Fresenius' Journal of Analytical Chemistry》1880,19(1):259-282
Ohne Zusammenfassung 相似文献