全文获取类型
收费全文 | 912篇 |
免费 | 38篇 |
国内免费 | 9篇 |
专业分类
化学 | 768篇 |
晶体学 | 1篇 |
力学 | 4篇 |
数学 | 96篇 |
物理学 | 90篇 |
出版年
2023年 | 6篇 |
2022年 | 4篇 |
2021年 | 15篇 |
2020年 | 16篇 |
2019年 | 23篇 |
2018年 | 11篇 |
2017年 | 8篇 |
2016年 | 29篇 |
2015年 | 28篇 |
2014年 | 28篇 |
2013年 | 50篇 |
2012年 | 65篇 |
2011年 | 71篇 |
2010年 | 62篇 |
2009年 | 42篇 |
2008年 | 61篇 |
2007年 | 52篇 |
2006年 | 37篇 |
2005年 | 50篇 |
2004年 | 54篇 |
2003年 | 27篇 |
2002年 | 41篇 |
2001年 | 20篇 |
2000年 | 15篇 |
1999年 | 5篇 |
1998年 | 4篇 |
1997年 | 17篇 |
1996年 | 11篇 |
1995年 | 6篇 |
1994年 | 5篇 |
1993年 | 10篇 |
1992年 | 8篇 |
1991年 | 6篇 |
1990年 | 7篇 |
1988年 | 3篇 |
1987年 | 6篇 |
1986年 | 4篇 |
1985年 | 4篇 |
1984年 | 3篇 |
1982年 | 4篇 |
1981年 | 4篇 |
1980年 | 8篇 |
1979年 | 8篇 |
1977年 | 2篇 |
1975年 | 2篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1939年 | 2篇 |
1924年 | 2篇 |
1923年 | 1篇 |
排序方式: 共有959条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
6.
Konstantin Dirian Susanne Backes Claudia Backes Volker Strauss Fabian Rodler Frank Hauke Andreas Hirsch Dirk M. Guldi 《Chemical science》2015,6(12):6886-6895
A water soluble naphthalenebisimide derivative (NBI) was synthesized and probed to individualize, suspend, and stabilize single wall carbon nanotubes (SWCNTs). Besides a comprehensive photophysical and electrochemical characterization of NBI, stable suspensions of SWCNTs were realized in buffered D2O. Overall, the dispersion efficiency of the NBI surfactant was determined by comparison with naphthalene based references. Successful individualization of SWCNTs was corroborated in several microscopic assays. In addition, emission spectroscopy points to the strong quenching of SWCNT centered band gap emission, when NBIs are immobilized onto SWCNTs. The origin of the quenching was found to be strong electronic communication, which leads to charge separation between NBIs and photoexcited SWCNTs, and, which yields reduced NBIs as well oxidized SWCNTs. Notably, electrochemical considerations revealed that the energy content of these charge separated states is one of the highest reported for SWCNT based electron donor–acceptor hybrids so far. 相似文献
7.
Anna-Lena Leistner Susanne Kirchner Johannes Karcher Tobias Bantle Mariam L. Schulte Peter Gödtel Christian Fengler Dr. Zbigniew L. Pianowski 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(31):8094-8099
Molecular photoswitches triggered with red or NIR light are optimal for photomodulation of complex biological systems, including efficient penetration of the human body for therapeutic purposes (“therapeutic window”). Yet, they are rarely reported, and even more rarely functional under aqueous conditions. In this work, fluorinated azobenzenes are shown to exhibit efficient E→Z photoisomerization with red light (PSS660nm >75 % Z) upon conjugation with unsaturated substituents. Initially demonstrated for aldehyde groups, this effect was also observed in a more complex structure by incorporating the chromophore into a cyclic dipeptide with propensity for self-assembly. Under physiological conditions, the latter molecule formed a supramolecular material that reversibly changed its viscosity upon irradiation with red light. Our observation can lead to design of new photopharmacology agents or phototriggered materials for in vivo use. 相似文献
8.
Per Martin Björemark Dr. Susanne Olsson Dr. Theonitsa Kokoli Prof. Mikael Håkansson 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(24):8750-8753
Even though the isolation of tetrahedral stereoisomers usually presents a synthetic challenge, a highly enantioenriched tetrahedral silver complex could be easily accessed by either crystallization or Viedma ripening. The overall preparation may be regarded as an example of absolute asymmetric synthesis. Experimental results indicate that both crystallization and Viedma ripening follow a similar cluster‐controlled mechanism. 相似文献
9.
Identification of Structure–Activity Relationships from Screening a Structurally Compact DNA‐Encoded Chemical Library 下载免费PDF全文
Dr. Raphael M. Franzini Dr. Torun Ekblad Dr. Nan Zhong Moreno Wichert Willy Decurtins Angela Nauer Mauro Zimmermann Dr. Florent Samain Dr. Jörg Scheuermann Dr. Peter J. Brown Prof. Dr. Jonathan Hall Dr. Susanne Gräslund Prof. Dr. Herwig Schüler Prof. Dr. Dario Neri 《Angewandte Chemie (International ed. in English)》2015,54(13):3927-3931
Methods for the rapid and inexpensive discovery of hit compounds are essential for pharmaceutical research and DNA‐encoded chemical libraries represent promising tools for this purpose. We here report on the design and synthesis of DAL‐100K, a DNA‐encoded chemical library containing 103 200 structurally compact compounds. Affinity screening experiments and DNA‐sequencing analysis provided ligands with nanomolar affinities to several proteins, including prostate‐specific membrane antigen and tankyrase 1. Correlations of sequence counts with binding affinities and potencies of enzyme inhibition were observed and enabled the identification of structural features critical for activity. These results indicate that libraries of this type represent a useful source of small‐molecule binders for target proteins of pharmaceutical interest and information on structural features important for binding. 相似文献
10.