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Masota Nelson E. Tibalinda Prosper Shedafa Raphael Sempombe Joseph Kaale Eliangiringa A. 《平面色谱法杂志一现代薄层色谱法》2016,29(6):469-473
JPC – Journal of Planar Chromatography – Modern TLC - A new high-performance thin-layer chromatographic (HPTLC)—densitometric method which can be employed in the routine analysis... 相似文献
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Sempombe J Galinato MG Elmore BO Fan W Guillemette JG Lehnert N Kirk ML Feng C 《Inorganic chemistry》2011,50(15):6859-6861
We have obtained low-temperature magnetic circular dichroism (MCD) spectra for ferric cyano complexes of the wild type and E546N mutant of a human inducible nitric oxide synthase (iNOS) oxygenase/flavin mononucleotide (oxyFMN) construct. The mutation at the FMN domain has previously been shown to modulate the MCD spectra of the l-arginine-bound ferric iNOS heme (Sempombe, J.; et al. J. Am. Chem. Soc. 2009, 131, 6940-6941). The addition of l-arginine to the wild-type protein causes notable changes in the CN(-)-adduct MCD spectrum, while the E546N mutant spectrum is not perturbed. Moreover, the MCD spectral perturbation observed with l-arginine is absent in the CN(-) complexes incubated with N-hydroxy-L-arginine, which is the substrate for the second step of NOS catalysis. These results indicate that interdomain FMN-heme interactions exert a long-range effect on key heme axial ligand-substrate interactions that determine substrate oxidation pathways of NOS. 相似文献
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Nyamweru Bugusu C. Sempombe Joseph Kaale Eliangiringa Layloff Thomas 《平面色谱法杂志一现代薄层色谱法》2014,27(1):47-51
JPC – Journal of Planar Chromatography – Modern TLC - A thin-layer chromatography (TLC) method for the analysis of clotrimazole was developed and validated according to the... 相似文献
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