Electrospun tin-carbon nanocomposite as anode material for all solid state lithium-ion batteries

Journal of Solid State Electrochemistry - All-solid-state batteries represent the next generation of electrochemical energy storage systems. A tin-carbon nanocomposite material is prepared by the...     

14-Hydroxylation of opiates: catalytic direct autoxidation of codeinone to 14-hydroxycodeinone

Codeinone (3) was efficiently and directly converted to 14-hydroxycodeinone (1) by catalytic air oxidation in aqueous solution. A number of simple manganese and copper salts were identified to be effective catalysts, including MnSO4, KMnO4, and CuSO4. An appropriate reducing agent, such as sodium thiosulfate, is required in the reaction mixture presumably for the reduction of a detrimental peroxide intermediate. This discovery allows the more abundant codeine to be employed as the starting material for the synthesis of 14-hydroxylated opiate drugs without recourse to a thebaine-like intermediate. These discoveries were inspired from our study of microbial transformation of codeine to 14-hydroxycodeine by Mycobacterium neoaurum, where we found the actual 14-hydroxylation step is a chemical reaction rather than an enzymatic reaction, as previously believed.