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Takuma Shinya Nakashima Noriyuki Tantirungkij Manee Kinoshita Shinichi Okada Hirosuke Sew TatsÜji Yoshida Toshiomi 《Applied biochemistry and biotechnology》1991,28(1):327-340
Applied Biochemistry and Biotechnology - A NADPH/NADH-dependent xylose reductase gene was isolated from the xylose-assimilating yeast,Pichia stipitis. DNA sequence analysis showed that the gene... 相似文献
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Chanama Manee Wunnakup Thaniya De-Eknamkul Wanchai Chanama Suchart 《平面色谱法杂志一现代薄层色谱法》2009,22(1):49-53
JPC – Journal of Planar Chromatography – Modern TLC - Plaunotol, an acyclic diterpenoid present in Croton stellatopilosus Ohba leaves, is a product of hydroxylation, catalyzed by... 相似文献
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Faisal Usman Hamid Saeed Shah Sumera Zaib Sirikhwan Manee Jahanzeb Mudassir Ajmal Khan Gaber El-Saber Batiha Khamael M. Abualnaja Dalal Alhashmialameer Imtiaz Khan 《Molecules (Basel, Switzerland)》2021,26(21)
Type 2 diabetes mellitus has been a major health issue with increasing morbidity and mortality due to macrovascular and microvascular complications. The urgent need for improved methods to control hyperglycemic complications reiterates the development of innovative preventive and therapeutic treatment strategies. In this perspective, xanthone compounds in the pericarp of the mangosteen fruit, especially α-mangostin (MGN), have been recognized to restore damaged pancreatic β-cells for optimal insulin release. Therefore, taking advantage of the robust use of nanotechnology for targeted drug delivery, we herein report the preparation of MGN loaded nanosponges for anti-diabetic therapeutic applications. The nanosponges were prepared by quasi-emulsion solvent evaporation method. Physico-chemical characterization of formulated nanosponges with satisfactory outcomes was performed with Fourier transform infra-red (FTIR) spectroscopy, differential scanning calorimetry (DSC), and scanning electron microscopy (SEM). Zeta potential, hydrodynamic diameter, entrapment efficiency, drug release properties, and stability studies at stress conditions were also tested. Molecular docking analysis revealed significant interactions of α-glucosidase and MGN in a protein-ligand complex. The maximum inhibition by nanosponges against α-glucosidase was observed to be 0.9352 ± 0.0856 µM, 3.11-fold higher than acarbose. In vivo studies were conducted on diabetic rats and plasma glucose levels were estimated by HPLC. Collectively, our findings suggest that MGN-loaded nanosponges may be beneficial in the treatment of diabetes since they prolong the antidiabetic response in plasma and improve patient compliance by slowly releasing MGN and requiring less frequent doses, respectively. 相似文献
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