Identification of a Prenyl Chalcone as a Competitive Lipoxygenase Inhibitor: Screening,Biochemical Evaluation and Molecular Modeling Studies

Cyclooxygenase (COX) and lipoxygenase (LOX) are key targets for the development of new anti-inflammatory agents. LOX, which is involved in the biosynthesis of mediators in inflammation and allergic reactions, was selected for a biochemical screening campaign to identify LOX inhibitors by employing the main natural product library of Brazilian biodiversity. Two prenyl chalcones were identified as potent inhibitors of LOX-1 in the screening. The most active compound, (E)-2-O-farnesyl chalcone, decreased the rate of oxygen consumption to an extent similar to that of the positive control, nordihydroguaiaretic acid. Additionally, studies on the mechanism of the action indicated that (E)-2-O-farnesyl chalcone is a competitive LOX-1 inhibitor. Molecular modeling studies indicated the importance of the prenyl moieties for the binding of the inhibitors to the LOX binding site, which is related to their pharmacological properties.     

The $$L^p$$ L p -Calderón–Zygmund inequality on non-compact manifolds of positive curvature

Annals of Global Analysis and Geometry - We construct, for $$p>n$$ , a concrete example of a complete non-compact n-dimensional Riemannian manifold of positive sectional curvature which does...     

Comparative efficacy of Eucalyptus globulus (Labill) hydrodistilled essential oil and temephos as mosquito larvicide

Abstract

In this study Eucalyptus globulus essential oil was tested on major mosquito species and toxicity was compared with temephos. Mortality was calculated after 24?h and 48?h post treatment. In 24?h treatment essential oil show strong larvicidal activity with LC₅₀ and LC₉₀ values were 30.198ppm, 103.389ppm for Anopheles stephensi, 13.578ppm, 106.755ppm for Aedes aegypti; and, 7.469ppm, 32.454ppm for Culex quinquefasciatus and 48?h post treatment LC₅₀ and LC₉₀ values were, 12.576, 49.380ppm for Anopheles stephensi, 7.926, 34.470ppm for Aedes aegypti and 4.408, 21.048ppm for Culex quinquefasciatus. Chemical composition of essential oil using GC-MS and FT-IR analysis shows the presence of 1,8-cineol, (71.7%); α-pinene, (9.14%) as a major compounds. Our findings suggest that essential oil from Eucalyptus globulus leaves can be used for control of mosquito larvae.     

Sub‐ and Supramolecular X‐Ray Characterization of Engineered Tissues from Equine Tendon,Bovine Dermis,and Fish Skin Type‐I Collagen

Collagen represents one of the most widely used biomaterial for scaffolds fabrication in tissue engineering as it represents the mechanical support of natural tissues. It also provides physical scaffolding for cells and it influences their attachment, growth, and tissue regeneration. Among all fibrillary collagens, type I is considered one of the gold standard for scaffolds fabrication, thanks to its high biocompatibility, biodegradability, and hemostatic properties. It can be extracted by chemical and enzymatic protocols from several collagen‐rich tissues, such as tendon and skin, of different animal species. Both the extraction processes and the manufacturing protocols for scaffolds fabrication provide structural and mechanical changes that can be tuned in order to deeply impact the properties of the final biomaterial. The aim of this review is to discuss the role of X‐rays to study structural changes of type I collagen from fresh collagen‐rich tissues (bovine, equine, fish) to the final scaffolds, with the aim to screen across available collagen sources and scaffolds fabrication protocols to be used in tissue regeneration.     

Correction to: Finite Element Approximation of the Spectrum of the Curl Operator in a Multiply Connected Domain

Foundations of Computational Mathematics - In the published article, Figure 5 corresponds to an eigenfunction associated not with the first smallest positive eigenvalue.     

Navier-stokes equations for compressible fluids: Global existence and qualitative properties of the solutions in the general case

We consider the equations which describe the motion of a viscous compressible fluid, taking into consideration the case of inflow and/or outflow through the boundary. By means of some a priori estimates we prove the existence of a global (in time) solution. Moreover, as a consequence of a stability result, we show that there exist a periodic solution and a stationary solution.