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Downstream modification of piperazin-2-ones obtained by the Castagnoli-Cushman reaction leads to a novel version of the medicinally relevant 1,2,5-benzothiadiazepin-4-one-1,1-dioxide scaffold. The relative stereochemistry remained trans as evidenced by the spectroscopic data and the single-crystal X-ray analysis. 相似文献
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Liubov V. Sokolenko Yurii L. Yagupolskii Liliia S. Kumanetska Jérôme Marrot Emmanuel Magnier Volodimir O. Lipetskij Ihor V. Kalinin 《Tetrahedron letters》2017,58(13):1308-1311
Methyl 3-(dimethylamino) acrylates containing trifluoromethylsulfenyl-, trifluoromethylsulfinyl-, and trifluoromethylsulfonyl groups were synthesized and their utility demonstrated by reactions with aliphatic and aromatic amidines to produce 2,5-substituted 4(3H)-pyrimidones. Cyclization reactions of enaminones with urea or thiourea led to 5-substituted uracil or 2-thiouracil derivatives, respectively. 相似文献
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Yafarova Liliia V. Silyukov Oleg I. Myshkovskaya Tatiana D. Minich Iana A. Zvereva Irina A. 《Journal of Thermal Analysis and Calorimetry》2021,143(1):87-93
Journal of Thermal Analysis and Calorimetry - Protonation and hydration processes of layered perovskite-like oxide KCa2Nb3O10 during the reaction with nitric acid solutions with different... 相似文献
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Kasian Natalia Vashchenko Olga Budianska Liliia Brodskii Roman Lisetski Longin 《Journal of Thermal Analysis and Calorimetry》2019,136(2):795-801
Journal of Thermal Analysis and Calorimetry - Phase transitions of multibilayer structures of hydrated L-α-dipalmitoyl- and L-α-dimyristoylphosphatidylcholine (DPPC and DMPC) were studied... 相似文献
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Rashmi Mahajan Mona Rouhi Sudhirkumar Shinde Thomas Bedwell Anil Incel Liliia Mavliutova Sergey Piletsky Ian A. Nicholls Brje Sellergren 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(3):737-740
We report an approach integrating the synthesis of protein‐imprinted nanogels (“plastic antibodies”) with a highly sensitive assay employing templates attached to magnetic carriers. The enzymes trypsin and pepsin were immobilized on amino‐functionalized solgel‐coated magnetic nanoparticles (magNPs). Lightly crosslinked fluorescently doped polyacrylamide nanogels were subsequently produced by high‐dilution polymerization of monomers in the presence of the magNPs. The nanogels were characterised by a novel competitive fluorescence assay employing identical protein‐conjugated nanoparticles as ligands to reversibly immobilize the corresponding nanogels. Both nanogels exhibited Kd<10 pM for their respective target protein and low cross‐reactivity with five reference proteins. This agrees with affinities reported for solid‐phase‐synthesized nanogels prepared using low‐surface‐area glass‐bead supports. This approach simplifies the development and production of plastic antibodies and offers direct access to a practical bioassay. 相似文献
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