Die Entwicklung kausaler Hypothesen in der qualitativen Sozialforschung

The disregard of causal inference in the methodological literature about qualitative research is highly problematic, since the category of causality is closely linked to the concept of social action. However, it is also clear that causal analysis is burdened with certain difficulties and methodological challenges in the realm of social research. Some of these problems are discussed in this article using Mackie—s concept of 3 “INUS”-conditions. Thereby it will be shown that strategies of causal analysis based on comparative methods proposed for qualitative research, namely “Analytic Induction” and “Qualitative Comparative Analysis” have great difficulties in dealing adequately with these problems. They can only be solved, if case-comparative methods are combined with explorative research strategies which support the researcher in gaining access to the local knowledge of the research field.     

An Improved Method for Preparation of Carboxylic Esters Using CsF-Celite/Alkyl Halide/Ch3Cn Combination

Preparations of compound 4 and of truxene derivatives 5, 6a,b, 7, 8, 10a, b, 11, 12a,b, and 13a,b are described. These substances are potential starting materials for the synthesis of bowl shaped polyaromatic compounds containing structural elements of fullerenes.     

Inventory control in dual sourcing commodity procurement with price correlation

Central European Journal of Operations Research - In this paper, we focus on the role of inventory management as a means for operational hedging by dual sourcing of commodities using a multi-period...     

Highway improvement project selection by the joint consideration of cost-benefit and risk criteria

Since highway improvement project selection requires screening thousands of road segments with respect to crashes for further analysis and final project selection, we provide a two-step project selection methodology and describe an application case to demonstrate its advantages. In the first step of the proposed methodology, we will use odds against observing a given crash count, injury count, run-off road count and so on as measures of risk and a multi-criteria pre-selection technique with the objective to decrease the number of prospective improvement locations. In the second step, the final project selection is accomplished based on a composite efficiency measure of estimated cost, benefit and hazard assessment (odds) under budget constraints. To demonstrate the two-step methodology, we will analyze 4 years of accident data at 23?000 locations where the final projects are selected out of several hundred of potential locations.     

Managing a dual-channel supply chain under price and delivery-time dependent stochastic demand

Several leading manufacturers recently combined the traditional retail channel with a direct online channel to reach a wider range of customers. We examine such a dual-channel supply chain under price and delivery-time dependent stochastic customer demand. We consider five decision variables, the price and order quantity for both the retail and the online channels and the delivery time for the online channel. Uncertainty frequently arises in both retail and online channels and so additional inventory management is required to control shortage or overstock and that has an effect on the optimal order quantity, price, and lead time. We developed mathematical models with the profit maximization motive. We analyze both centralized and decentralized systems for unknown distribution function of the random variables through a distribution-free approach and also for known distribution function. We examine the effect of delivery lead time and customers’ channel preference on the optimal operation. For supply chain coordination a hybrid all-unit quantity discount along a franchise fee contract is used. Moreover, we use the generalized asymmetric Nash bargaining for surplus profit distribution. A numerical example illustrates the findings of the model and the managerial insights are summarized for centralized, decentralized, and coordinated scenarios.     

Stocking of Prescribed Sizes of an Item

In this paper we consider an item that is sold in a number of different prescribed sizes, an example being an item of clothing. We first deal with the situation where the total demand for a forthcoming period is known accurately but only historical or subjective estimates of the fractions of demand in each size are available. A procedure is developed for optimally allocating a given stock budget among the different sizes. Its performance is compared with a simpler, proportional allocation scheme. The numerical examples include data on clothing provided by a major municipal organization. The case where the total demand is a random variable is also treated.     

Dual sourcing using capacity reservation and spot market: Optimal procurement policy and heuristic parameter determination

This contribution focuses on the cost-effective management of the combined use of two procurement options: the short-term option is given by a spot market with random price, whereas the long-term alternative is characterized by a multi period capacity reservation contract with fixed purchase price and reservation level. A reservation cost, proportional with the reservation level, has to be paid for the option of receiving any amount per period up to the reservation level. A long-term decision has to be made regarding the reserved capacity level, and then it has to be decided – period by period – which quantities to procure from the two sources. Considering the multi-period problem with stochastic demand and spot price, the structure of the optimal combined purchasing policy is derived using stochastic dynamic programming. Exploiting these structural properties, an advanced heuristic is developed to determine the respective policy parameters. This heuristic is compared with two rolling-horizon approaches which use the one-period and two-period optimal solution. A comprehensive numerical study reveals that the approaches based on one-period and two-period solutions have considerable drawbacks, while the advanced heuristic performs very well compared to the optimal solution. Finally, by exploiting our numerical results we give some insights into the system’s behavior under problem parameter variations.     

Long-Term Monokaryotic Cultures of Pleurotus ostreatus var. florida Produce High and Stable Laccase Activity Capable to Degrade ß-Carotene

An extracellular laccase (Lacc10) was discovered in submerged cultures of Pleurotus ostreatus var. florida bleaching ß-carotene effectively without the addition of a mediator (650 mU/L, pH 4). Heterologous expression in P. pastoris confirmed the activity and structural analyses revealed a carotenoid-binding domain, which formed the substrate-binding pocket and is reported here for the first time. In order to increase activity, 106 basidiospore-derived monokaryons and crosses of compatible progenies were generated. These showed high intraspecific variability in growth rate and enzyme formation. Seventy-two homokaryons exhibited a higher activity-to-growth-rate-relation than the parental dikaryon, and one isolate produced a very high activity (1800 mU/L), while most of the dikaryotic hybrids showed lower activity. The analysis of the laccase gene of the monokaryons revealed two sequences differing in three amino acids, but the primary sequences gave no clue for the diversity of activity. The enzyme production in submerged cultures of monokaryons was stable over seven sub-cultivation cycles.