排序方式: 共有24条查询结果,搜索用时 15 毫秒
1.
Aishakhanam H. Pathan Ganesh N. Naik Raghavendra P. Bakale Shrinath S. Machakanur Kalagouda B. Gudasi 《应用有机金属化学》2012,26(3):148-155
A series of Co(II), Ni(II), Cu(II), and Zn(II) complexes of a tridentate hydrazone were prepared and characterized by various spectro‐analytical techniques and magnetic moment studies. The complexes were found to be monomeric and non‐electrolytes. The copper complex is electrochemically active in the applied potential range. The compounds synthesized in the present study have shown promising antiproliferative activity when screened using the in vitro method against two human cancer cell lines: HeLa and HepG2. The Escherichia coli DNA‐binding properties of all the compounds were investigated with UV–visible absorption spectrophotometric titrations, viscosity measurements, DNA melting experiments and gel electrophoreses measurements. The compounds were demonstrated to act as DNA intercalators with appreciable DNA‐binding constant values. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
2.
Geeta H. Chimmalagi Umashri Kendur Sunil M. Patil Christopher S. Frampton Kalagouda B. Gudasi Delicia A. Barretto Chandrashekhar V. Mangannavar Iranna S. Muchchandi 《应用有机金属化学》2019,33(1)
A series of mononuclear metal complexes of Co(III), Ni(II) and Cu(II) with 2‐(2,4‐dichlorobenzamido)‐N′‐(3,5‐di‐tert‐butyl‐2‐hydroxybenzylidene)benzohydrazide ( LH 3 ) have been synthesized and characterized using various physico‐chemical, spectroscopic and single crystal X‐ray diffraction techniques. Structural studies of [Co( LH )( LH 2 )]·H2O ( 4 ) revealed the presence of both amido and imidol tautomeric forms of LH 3 , resulting in a distorted octahedral geometry around the Co(III) ion. [Ni( LH )(H2O)]·H2O ( 5 ) and [Cu( LH )(H2O)]·H2O ( 6 ) are isomorphous structures and crystallize in the monoclinic P21/c space group. The crystal structures of 4 , 5 and 6 are stabilized by hydrogen bonds formed by the enclathrated water molecules, C‐H···π and π···π interactions. Complexes along with the ligand ( LH 3 ) were screened for their in vivo anti‐inflammatory activity (carrageenan‐induced rat paw edema method) and in vitro antioxidant activity (DPPH free radical scavenging assay). Metal complexes have shown significant anti‐inflammatory and antioxidant potential. 相似文献
3.
Synthesis and characterization of transition metal complexes of hydrochloride salt of 3‐chlorobenzaldehyde hydralazine hydrazone: a new class of possible anti‐cariogenic agents 下载免费PDF全文
Raghavendra P. Bakale Aishakhanam H. Pathan Ganesh N. Naik Shrinath S. Machakanur Chandrashekhar V. Mangannavar Iranna S. Muchchandi Kalagouda B. Gudasi 《应用有机金属化学》2014,28(9):720-724
A novel hydrazone, formed by the condensation of the hydrochloride salt of hydralazine with 3‐chlorobenzaldehyde, and its Co(II), Ni(II), Cu(II) and Zn(II) complexes have been synthesized. Their structures have been elucidated on the basis of elemental analyses, conductance measurements, magnetic moments, and spectral (infrared, 1H NMR, UV–visible, electrospray ionization (ESI) mass) and thermal studies. The bidentate behaviour of the ligand is proposed on the basis of spectral studies. Interestingly, all four complexes exhibit different geometry around the metal centre. The conductance data of the complexes suggest them to be non‐electrolytes. The ESI mass spectra of the complexes support their monomeric nature. The compounds were tested against two Gram‐positive and three Gram‐negative bacterial strains and three fungal strains. Excellent inhibitory activity is observed against the Gram‐positive bacteria Streptococcus mutans and Enterococcus faecalis which play major roles in tooth decay. Among the fungal strains used, Candida albicans is inhibited predominantly. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
4.
Co(II), Ni(II), Cu(II) and Zn(II) complexes of isatinyl‐2‐aminobenzoylhydrazone: synthesis,characterization and anticancer activity 下载免费PDF全文
Rekha S. Hunoor Basavaraj R. Patil Dayananda S. Badiger Chandrashekhar V. M. I. S. Muchchandi Kalagouda B. Gudasi 《应用有机金属化学》2015,29(2):101-108
This article describes the synthesis, structural aspects and biological studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes of a new hydrazone derived from the condensation of isatin and 2‐aminobenzoylhydrazide. The ligand is well characterized using 1H NMR, 13C NMR, 2D HETCOR, mass and IR spectral studies. The chelating tendency of the ligand towards transition metal ions is established using analytical and spectral studies, which reveal the monobasic tridentate nature of the ligand. Octahedral geometry for Co(II), Cu(II) and Zn(II) and tetrahedral geometry for Ni(II) are tentatively proposed. All the synthesized compounds were screened for in vitro anticancer activity against Ehrlich ascites carcinoma and human cancer cell lines (adenocarcinoma HT29, kidney cancer cell line K293 and breast cancer cell line MDA231) using tryphan blue exclusion method and MTT assay. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
5.
Rekha S. Hunoor Basavaraj R. Patil Dayananda S. Badiger Ramesh S. Vadavi Kalagouda B. Gudasi V. M. Chandrashekhar I. S. Muchchandi 《应用有机金属化学》2011,25(6):476-483
A new quinazolinone derivative, 3‐[1‐(2‐hydroxyphenyl)ethylideamino]‐2‐phenyl‐3,4‐dihydroquinazolin‐4(3H)‐one ( LH ) was synthesized by the condensation of 2‐hydroxyacetophenone‐2‐aminobenzoylhydrazone and benzaldehyde. The cyclization to form 1,2‐dihydroquinazolinone was confirmed by IR, 1D and 2D HETCOR studies. Coordination compounds of Co(II), Ni(II), Cu(II) and Zn(II) of LH were synthesized and characterized using various physico‐chemical studies like stoichiometric, conductivity, magnetic moment measurements and spectral techniques such as IR, NMR, UV‐vis and EPR spectroscopy. The elemental analysis and thermal studies suggested a general stoichiometry [M(HEPDQ)Cl] for all the complexes. A four‐coordinate geometry was assigned to all the complexes. The complexes along with the parent ligand were screened for their anti‐inflammatory activity, using carrageenan‐induced rat paw edema, and for their analgesic activity by Eddy's hot plate method. The activity of the ligand was enhanced on complexation with metal ions. This enhanced activity was attributed to the increased lipophilic nature of the complexes. Notable anti‐inflammatory activity was observed for Ni(II), Cu(II) and Zn(II) complexes. The analgesic activity of the ligand was greater than the standard at 60 min. and at a 10 mg kg−1 dose, whereas the activity of Ni(II) and Cu(II) complexes at 10 mg kg−1 dose was comparable with the standard used. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
6.
Vadavi RS Shenoy RV Badiger DS Gudasi KB Devi LG Nethaji M 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2011,79(2):348-355
The coordinating behavior of a new dihydrazone ligand, 2,6-bis[(3-methoxysalicylidene)hydrazinocarbonyl]pyridine towards manganese(II), cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) has been described. The metal complexes were characterized by magnetic moments, conductivity measurements, spectral (IR, NMR, UV-Vis, FAB-Mass and EPR) and thermal studies. The ligand crystallizes in triclinic system, space group P-1, with α=98.491(10)°, β=110.820(10)° and γ=92.228(10)°. The cell dimensions are a=10.196(7)?, b=10.814(7)?, c=10.017(7)?, Z=2 and V=1117.4(12). IR spectral studies reveal the nonadentate behavior of the ligand. All the complexes are neutral in nature and possess six-coordinate geometry around each metal center. The X-band EPR spectra of copper(II) complex at both room temperature and liquid nitrogen temperature showed unresolved broad signals with g(iso)=2.106. Cyclic voltametric studies of copper(II) complex at different scan rates reveal that all the reaction occurring are irreversible. 相似文献
7.
KB McTiernan SC Jarvis D Allen R Bol D Scholefield 《Rapid communications in mass spectrometry : RCM》1999,13(18):1803-1807
The composition of dissolved organic matter (DOM) in a soil is the product of a variety of soil processes. Changes in the composition of DOM in water discharged from soil should, therefore, give an important insight into modifications in these soil processes. We hypothesise that these processes in soils, under different grassland management regimes, would be affected to different extents by the short-term disturbance of a storm event and that evidence of this could be detected in delta(13)C and delta(15)N signatures in drainage and surface runoff waters. During a storm event we collected discharge waters from 1 ha grassland lysimeters, with or without artificial drainage, which received contrasting fertiliser inputs, and delta(13)C and delta(15)N signatures were determined. Changes in (13)C enrichment during the storm event were clearly identifiable, as were differences between plots for (13)C and (15)N, illustrating that this technique has potential to be a useful tool for identifying and investigating short- and long-term changes in soil organic matter dynamics. Copyright 1999 John Wiley & Sons, Ltd. 相似文献
8.
Kalagouda B. Gudasi Rashmi V. Shenoy Ramesh S. Vadavi Manjula S. Patil Siddappa A. Patil 《Journal of inclusion phenomena and macrocyclic chemistry》2006,55(1-2):93-101
Reaction of Ln(NO3)3 with 2,6-bis[(3-methoxysalicylidene)hydrazino carbonyl]pyridine (BMSPD) afforded binuclear complexes of the type [Ln2(BMSPD)(NO3)2(H2O)5]·3H2O in case of La(III), Pr(III), Nd(III), Sm(III), Eu(III), Gd(III), Tb(III) and Dy(III), and [Ln2(BMSPD)(NO3)2(H2O)5] in case of Y(III). The mode of coordination of ligand and the conformational changes on complexation with lanthanides was studied based on elemental analysis, magnetic studies, TG/DTA, IR, 1H-NMR, Electronic, EPR and Fluorescence spectral studies. The ligand coordinates to one metal centre through enolized deprotonated carbonyls and pyridine nitrogen whereas doubly deprotonated phenolate oxygens and two hydrazonic nitrogens ligate to another lanthanide centre. Both the metal ions are in eight-coordination environments. The ligand and complexes were further tested for antifungal and antibacterial activities. 相似文献
9.
Gudasi KB Shenoy RV Vadavi RS Patil SA 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2006,65(3-4):598-604
Trinuclear lanthanide complexes of the formula [Ln(3)(PPDA)(NO(3))(6)(H(2)O)(2)].NO(3).2H(2)O where Ln=La(III), Pr(III), Sm(III), Nd(III), Eu(III) Gd(III) Tb(III), Dy(III) and Y(III); H(2)PPDA=N,N'-bis(2-pyridinyl)-2,6-pyridinedicarboxamide, have been isolated. The complexes were characterized by elemental analyses, conductivity measurements, magnetic susceptibility measurements and spectral (IR, NMR, UV-vis, fluorescence, FAB and EPR) and thermal studies. 相似文献
10.
Kalagouda B. Gudasi Manjula S. Patil Ramesh S. Vadavi Rashmi V. Shenoy Siddappa A. Patil 《Transition Metal Chemistry》2006,31(8):986-991
A new tetradentate NOOO-donor ligand, N-(salicylidene)nitrosophenylglycine (H2snpg) has been designed, synthesized and structurally characterized. Copper(II), nickel(II), cobalt(II), manganese(II) and
zinc(II) complexes of H2snpg have been prepared for the first time. The authenticities of the ligand and its metal complexes have been established
on the basis of elemental analyses, molar conductance measurements, magnetic properties, spectral (i.r., 1H-n.m.r., u.v.–vis. and mass) studies. The i.r. spectral studies of all the complexes exhibit a similar feature about the
ligating nature of the ligand to the metal ions and revealed that the ligand has coordinated through the carbonyl oxygen,
azomethine nitrogen, nitroso oxygen and deprotonated hydroxyl oxygen. The molar conductance data suggest them to be non-electrolytes.
The antimicrobial activity of all the compounds was studied against Escherichia coli, Bacillus cirroflagellosus, Aspergillus niger and Candida albicans. All the complexes have shown a moderate to high fungal activity compared to the ligand. 相似文献