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Antonio Dell'Isola Dr. Matthew M. W. McLachlan Dr. Benjamin W. Neuman Hawaa M. N. Al‐Mullah Alexander W. D. Binks Warren Elvidge Dr. Kenneth Shankland Dr. Alexander J. A. Cobb 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(37):11685-11689
An efficient synthesis of spirocyclic triazolooxazine nucleosides is described. This was achieved by the conversion of β‐D ‐psicofuranose to the corresponding azido‐derivative, followed by alkylation of the primary alcohol with a range of propargyl bromides, obtained by Sonogashira chemistry. The products of these reactions underwent 1,3‐dipolar addition smoothly to generate the protected spirocyclic adducts. These were easily deprotected to give the corresponding ribose nucleosides. The library of compounds obtained was investigated for its antiviral activity using MHV (mouse hepatitis virus) as a model wherein derivative 3 f showed the most promising activity and tolerability. 相似文献
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J. Bloxsidge J. A. Elvidge J. R. Jones E. A. Evans 《Magnetic resonance in chemistry : MRC》1971,3(1):127-138
Routine measurement of triton magnetic resonance spectra is described for the first time, using a micro-bulb sample tube assembly to obviate radiological hazards. Levels of isotope abundance and chemical concentration, the problem of self-radiolysis and the general usefulness of the technique are discussed. Results are given for a selection of compounds including glucose, amino-acids, thymidine and uridine. The self-radiolysis of the last is followed. 相似文献
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Avent AG Cloke FG Elvidge BR Hitchcock PB 《Dalton transactions (Cambridge, England : 2003)》2004,(7):1083-1096
Novel yttrium chelating diamide complexes [(Y[ArN(CH(2))(x)NAr](Z)(THF)(n))(y)] (Z = I, CH(SiMe(3))(2), CH(2)Ph, H, N(SiMe(3))(2), OC(6)H(3)-2,6-(t)Bu(2)-4-Me; x = 2, 3; n = 1 or 2; y = 1 or 2) were made via salt metathesis of the potassium diamides (x = 3 (3), x = 2 (4)) and yttrium triiodide in THF (5,10), followed by salt metathesis with the appropriate potassium salt (6-9, 11-13, 15) and further reaction with molecular hydrogen (14). 6 and 11(Z = CH(SiMe(3))(2), x = 2, 3) underwent unprecedented exchange of yttrium for silicon on reaction with phenylsilane to yield (Si[ArN(CH(2))(x)NAr]PhH) (x = 2 (16), 3) and (Si[CH(SiMe(3))(2)]PhH(2)). 相似文献
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James P. Bloxsidge John A. Elvidge John R. Jones E. Anthony Evans J. Philip Kitcher David C. Warrell 《Magnetic resonance in chemistry : MRC》1981,15(2):214-217
The complete analysis of the tritium distribution in tritiated methyl groups in labelled compounds is achieved by a direct method for the first time, through 3H NMR spectroscopy aided by resolution enhancement. 相似文献
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Michael J. Blandamer John Burgess Diane L. Elvidge Pilar Guardado Andrew W. Hakin Lesley J. S. Prouse Stojan Radulović David R. Russell 《Transition Metal Chemistry》1991,16(1):82-91
Summary The structure of the tetrahydrate of the nitroprusside salt of the tris-ligand-FeII complex of the Schiff base derived from 2-acetyl pyridine and methylamine has been established by x-ray diffraction methods. The cation has themer-configuration in this salt in the solid phase. Kinetic and spectroscopic, particularly1H n.m.r., results indicate that bothmer-andfac-isomers of this, and of related complexes, have to be considered in solution. Kinetics of base hydrolysis of the title cation, and its solvation, in MeOH-H2O mixtures are described and compared with those for other low-spin FeII-diimine complexes. 相似文献
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A selective high-performance liquid chromatographic procedure has been developed for the determination of the major Ipecacuanha alkaloids, emetine and cephaeline, in a number of linctus and pastille preparations. The reversed-phase chromatographic procedure uses an octadecyl-bonded column with a mobile phase of aqueous methanol containing an ion-pairing reagent. A spectrofluorimetric detector is used for increased sensitivity and selectivity. Sample preparation is simple, involving either straight dilution for linctus formulations or simple dissolutions for pastilles. The procedure has been shown to be stability-indicating. Validation studies, to show that the method is precise, accurate and rectilinear, have been carried out on four linctus formulations and two pastille formulations. The method has been used to determine both emetine and cephaeline at levels as low as 5 micrograms/g in formulations. 相似文献