Towards Stereoselective Synthesis of the C(31)–C(39) and C(20)–C(27) Fragments of Phorboxazole A

The stereoselective synthesis of the C(31)–C(39) and C(20)–C(27) fragments of phorboxazole A ( 1 ) was achieved from commercially available and inexpensive D ‐mannitol. Crimmins aldol reaction and a decarboxylative Claisen‐type reaction are the key steps for the C(31)–C(39) fragment, and L ‐proline‐catalyzed aldol reaction, Sharpless asymmetric epoxidation, and epoxide ring opening reaction with Gilman's reagent are the key steps for the C(20)–C(27) fragment of phorboxazole.     

La2O3 promotional effect to Co3O4/γ-Al2O3 catalyst in the oxidative dehydrogenation of ethylbenzene with CO2 as soft oxidant

Co₃O₄/γ-Al₂O₃ catalysts with variable Co₃O₄ loadings (5–20 wt%) and deposition of 15% Co₃O₄ on La₂O₃/γ-Al₂O₃ were prepared by wet impregnation method. La₂O₃-γ-Al₂O₃ support with variable composition of La₂O₃ (2–6 wt%) were prepared by co-precipitation method. All the catalysts were tested for oxidative dehydrogenation of ethylbenzene with CO₂ as soft oxidant. Among the Co₃O₄/γ-Al₂O₃ catalysts, 15% Co₃O₄/γ-Al₂O₃ has shown good performance and hence this catalyst has been chosen to investigate the effect of La₂O₃ species. CO₂ pulse chemisorption data indicate more amount of CO₂ uptake over 15% Co₃O₄/4%La₂O₃/γ-Al₂O₃ catalyst which clearly indicates that this catalyst exhibits good performance in ethylbenzene dehydrogenation with CO₂ as soft oxidant because of reverse water gas shift reaction. Temperature programmed reduction studies indicate that the Co₃O₄ catalysts follow two step reduction mechanism from Co₃O₄ to CoO and then to Co and La₂O₃ promotional effect is visible through facile reduction of Co₃O₄ species. La₂O₃ doping has a vital influence in getting enhanced ethylbenzene conversion, styrene yield and alleviates catalyst deactivation compared to that of unpromoted Co₃O₄/γ-Al₂O₃ catalyst. TGA studies indicate the presence low amount coke deposition during time-on-stream over 15% Co₃O₄/4%La₂O₃/γ-Al₂O₃ catalyst compared to 15% Co₃O₄/γ-Al₂O₃ catalyst.     

Numerical Computation of Heat and Mass Transfer in Fluidized Beds with Liquid Injection

The goal of this work is the simulation of concentration and temperature distributions insides fluidized bed with a uniform liquid distribution. Further, a physically based 2D model is developed for the heat and mass transfer processes in fluidized beds with a spray nozzle. The model is a coupled and semi-linear system of convection-reaction-diffusion equations. We considered the numerical solution of these semi-linear partial differential equations with discrete boundary conditions using linear finite elements on an adaptive triangular grid in space and implicit methods in time. We present calculations using, semi implicit and implicit methods in time, and different solvers for solving the linear systems. The complex correlations of mass and liquid flow rates, mass transfer, heat transfer, drying, and transient two dimensional air humidity, air temperature, degree of wetness, liquid film temperature and particle temperature were simulated. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)     

Bremsstrahlung shielding parameters in polymer concretes

Concretes are used for shielding in nuclear power plants. Beta radiation is emitted during the nuclear reactions. This beta radiation interacts with the concrete and results in secondary radiation such as bremsstrahlung. Shielding parameters of beta-induced bremsstrahlung in concretes are important in the field of radiation protection. We have evaluated the cross section, yield, intensity and dose rate of beta-induced bremsstrahlung by pure beta nuclides of end point energy ranges from 0.4 to 5?MeV in some polymer-based concretes such as sulfur polymer concrete, barium polymer concrete, calcium polymer concrete, fluorine polymer concrete, chlorine polymer concrete and germanium polymer concrete. We have compared the shielding properties among the studied polymer concretes. The efficiency, intensity and dose rate of bremsstrahlung increases with a maximum energy of beta nuclide and modified atomic number of the concrete. From the detailed study, it is clear that the barium polymer concrete is having large bremsstrahlung dose rate and specific bremsstrahlung constant values than the other studied polymer concretes. This means barium polymer concrete is a good absorber of bremsstrahlung radiation than the other studied polymer concretes.     

Stereoselective synthesis of (S,S)-palythazine from d-mannitol

Exploiting the symmetry element, an asymmetric synthesis of (S,S)-palythazine was accomplished with (R)-glyceraldehyde acetonide as the chiral precursor. The prominent steps involved stereoselective Barbier allylation, ring-closing metathesis, regioselective nucleophilic opening of epoxide, and auto-condensation of aminoketone moiety.     

采用燃烧技术制备CuO纳米粒子:一种高效且环境友好的用于芳族醛合成芳族腈催化剂(英文)

CuO nanoparticles were synthesized using an energy-efficient and rapid solution combustion technique with malic acid employed as a fuel. The combustion-derived CuO nanoparticles were used as catalysts in a one-pot synthesis of aromatic nitriles from aromatic aldehydes and hydroxylamine hydrochloride. The catalyst was characterized by X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray analysis, transmission electron microscopy, and Brunauer-Emmett-Teller surface area analysis. The catalytic activity of the CuO nanoparticles in the synthesis of aromatic nitriles from aromatic aldehydes was evaluated. The present protocol offers the advantages of a clean reaction, simple methodology, short reaction duration (1-2 min), and high yield (85%-98%). The catalytic activity of the CuO nanoparticles was found to be higher than that of bulk CuO powder under the same conditions. The catalyst can also be recovered and reused up to four times with no significant loss of catalytic activity. The present approach is inexpensive and is a convenient technique suitable for industrial production of CuO nanoparticles and nitriles.     

Efficient Protocol for Reductive Amination of Aldehydes and Ketones with Sodium Borohydride in an Ionic Liquid/H2O System

The imines were generated in situ from carbonyl compounds and amines, which undergo smooth reduction with sodium borohydride in an ionic liquid/H₂O solvent system. The reaction conditions were very mild and neutral to afford the corresponding highly functionalized amines in excellent yields.     

First Stereoselective Total Synthesis of Oplopandiol

The first stereoselective synthesis of the naturally occurring conjugated diyne oplopandiol is reported. The pivotal functionalities are derived from Cadiots? Chodkiewicz cross‐coupling reaction, Ohira? Bestmann alkynation, asymmetric Noyori reduction, and cis‐olefination reaction