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Drechsler U Erdogan B Rotello VM 《Chemistry (Weinheim an der Bergstrasse, Germany)》2004,10(22):5570-5579
Monolayer and mixed-monolayer protected clusters (MPCs and MMPCs) have great potential to combine molecular functionality with the intrinsic properties of nanometer-sized scaffolds. This synergy can be used to create complex functional devices, including redox-active, electronic, or magnetic storage devices, solution-based sensors, and highly efficient catalysts. This review outlines some of the recent developments in nanoscale receptors based on synthetic and nonbiological recognition elements. In these nanoparticle systems, molecular recognition is achieved by covalent attachment of receptors on the nanoparticles coupled with noncovalent interactions to target substrates. Synthetic host-guest systems, hydrogen bonding, change in redox states, pi-pi stacking, rotaxane formation, and ion recognition are the main topics covered in this review. 相似文献
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Selenium has been identified as an essential dietary trace e1ementQ)which is a component of glutathione peroxidase (GSH-Px)(2)and a cytochrome C-like protein(3), The enzyme,the four subunits of which each contain one atom of selenium in the form of selenocysteine, the selenium containing active centre being amenable to chemical modification, catalyses the reduction of H,O,and organic hydroperoxides to water.In this way GSH-Px plays an important role in the protection of the cell from oxidative stresses such as the superoxide anion,organic hydroperoxides and H2O2 相似文献
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Belma Hasdemir 《合成通讯》2013,43(9):1082-1088
Sixteen chiral β-, γ-, and δ-hydroxy esters with aryl, substituted aryl, and heteroaryl groups 2a–2s were synthesized by the asymmetric reduction of their corresponding keto esters 1a–1s as chiral pure reference compounds and starting materials. The asymmetric reduction was achieved by (R)-Me-CBS-oxazaborolidine. Ten new chiral γ- and δ-hydroxy esters 2d, 2e, and 2j–2s were obtained with high ee values and characterized by infrared, NMR (1H and 13C), mass spectrometry, chiral high-performance liquid chromatography, and specific rotation. 相似文献
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Avcı Davut Altürk Sümeyye Sönmez Fatih Tamer Ömer Başoğlu Adil Atalay Yusuf Zengin Kurt Belma Dege Necmi 《Molecular diversity》2021,25(1):171-189
Molecular Diversity - The World Health Organization (WHO) report shows that diabetes mellitus (DM) will be one of the ten deadly diseases in the near future. The best way to prevent DM is to... 相似文献
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Zehra Durmus Belma Zengin Kurt Işıl Gazioğlu Ece Sevgi Cagla Kizilarslan Hancer 《应用有机金属化学》2020,34(3):e5375
MIL53(Al)-SiO2@Fe3O4 composite was prepared by co-precipitation route with a typical Stöber synthetic process and ultrasonic-agitation, then subsequently utilized as a multi-component novel sorbent in solid-phase microextraction (SPME) of aflatoxin B1 in winter herbal teas. Microstructural properties of MIL53(Al)-SiO2@Fe3O4 composite was characterized by using Fourier transform infrared (FTIR) spectroscopy, powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) methods, and Brunauer–Emmett–Teller (BET) surface area measurement. The MIL53(Al)-SiO2@Fe3O4 composite was found to be a very effective sorbent in spectrofluorimetric determination of aflatoxin B1 (AFB1) in winter herbal teas via magnetic solid-phase extraction (SPE) route. The proposed method showed a wide linear range from 0.5 to 150 ng/ml, low limit of detection (LOD = 0.5 ng/ml), and an acceptable recovery values (70.7–96.5%) in real samples analysis. This study shows that the suggested method possesses an important potential to use for detecting AFB1 in quality control laboratories. 相似文献
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Davut Avcı Sümeyye Altürk Fatih Sönmez Ömer Tamer Adil Başoğlu Yusuf Atalay Belma Zengin Kurt Necmi Dege 《Tetrahedron》2018,74(50):7198-7208
Novel complexes of 6?methylpyridine?2?carboxylic acid and thiocyanate {[Cu(NCS)(6-mpa)2], (1); [Cd(NCS)(6-mpa)]n, (2); [Cr(NCS)(6-mpa)2·H2O], (3)} were synthesized, and their structures were characterized by XRD analysis, FT–IR and UV–Vis spectroscopic techniques. The inhibitory activities of the synthesized complexes (1–3) on α-glucosidase were determined by using genistein reference compound. Furthermore, the optimized geometry and vibrational harmonic frequencies for the complexes 1–3 were obtained by DFT/HSEh1PBE/6–311G(d,p)/LanL2DZ level. Electronic spectral properties were examined by using TD-DFT/HSEh1PBE/6–311G(d,p)/LanL2DZ level with CPCM model. Additionally, major contributions to the electronic transitions were determined via Swizard program. The refractive index, linear optical and non?nonlinear optical parameters of the complexes 1–3 were investigated at HSEh1PBE/6–311G(d,p) level. The docking studies of the complexes 1–3 to the binding site of the target protein (the template structure S. cerevisiae isomaltase are fulfilled. Lastly, natural bond orbital analysis was used to investigate inter- and intra-molecular bonding and interaction among bonds. 相似文献
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Davut Avc Sümeyye Altürk Fatih Snmez
mer Tamer Adil Baolu Yusuf Atalay Belma Zengin Kurt Necmi Dege 《应用有机金属化学》2019,33(7)
Novel complexes of 6‐methylpyridine‐2‐carboxylic acid and 4(5)methylimidazole, namely [Mn(6‐mpa)2(4(5)MeI)2] ( 1 ), [Zn(6‐mpa)2(4(5)MeI)2] ( 2 ), [Cd(6‐mpa)2(4(5)MeI)2] ( 3 ), [Co(6‐mpa)2(4(5)MeI)2] ( 4 ), [Ni(6‐mpa)2(4(5)MeI)(OAc)] ( 5 ) and [Cu(6‐mpa)2(4(5)MeI)] ( 6 ), were synthesized for the first time. The structures of complexes 1 – 4 and complexes 5 and 6 were determined using X‐ray diffraction and mass spectrometric techniques, respectively. The experimental spectral analyses for these complexes were performed using Fourier transform infrared and UV–visible techniques. The α‐glucosidase inhibition activity values (IC50) of complexes 1 – 6 were identified in view of genistein reference compound. Moreover, the DFT/HSEh1PBE/6‐311G(d,p)/LanL2DZ level was used to obtain optimal molecular geometry and vibrational wavenumbers for complexes 1 – 6 . Electronic spectral behaviours and major contributions to the electronic transitions were investigated using TD‐DFT/HSEh1PBE/6‐311G(d,p)/LanL2DZ level with conductor‐like polarizable continuum model and SWizard program. Finally, in order to investigate interactions between the synthesized complexes ( 1 – 6 ) and target protein (template structure S. cerevisiae isomaltase), a molecular docking study was carried out. 相似文献
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Davut Avc Sümeyye Altürk Fatih Snmez
mer Tamer Adil Baolu Yusuf Atalay Belma Zengin Kurt Dilek
ztürk Necmi Dege 《应用有机金属化学》2019,33(3)
A new dinuclear copper (II) complex of 2,5–furandicarboxyclic acid with 4(5)‐methylimidazole, [Cu (FDCA)((4(5)MeI)2]2·2H2O, was synthesized, and its structure characterized by XRD, FT–IR and UV–Vis spectroscopic techniques. The α‐glucosidase inhibition and cytotoxicity study of the synthesized Cu (II) complex were determined by IC50 values. The optimized geometry and vibrational harmonic frequencies for the Cu (II) complex were obtained by using Density Functional Theory (DFT) of HSEh1PBE/6–311++G(d,p)/LanL2DZ level. TD‐DFT/HSEh1PBE/6–311++G(d,p)/LanL2DZ level with CPCM model was applied to examine the electronic spectral properties and major contributions were determined via Swizard program. To investigate linear and nonlinear optical behavior of the synthesized Cu (II) complex, the α, Δα and χ(1)/β, γ and χ(3) parameters called linear/nonlinear optical parameters in gas phase and ethanol solvent were computed at the same level and basis set. Furthermore, molecular electrostatic potential (MEP) surface was determined by using the same level. The docking study of the Cu (II) complex to the binding site of the target protein (the template structure S. cerevisiae isomaltase) is fulfilled. Natural bond orbital (NBO) analysis was used to investigate the hyperconjugative interactions, inter‐ and intra‐molecular bonding and to determine coordination around Cu (II) ion. Finally, present work is the first remarkable scientific report of mixed‐ligand (H2FDCA and 4(5)MeI) Cu (II) complex as novel drug candidate for DM II. It is also determined that microscopic third?NLO parameters for the Cu (II) complex is remarkable. 相似文献