Synthesis and Crystal Structure of (S)-N-(2-oxoazepan-3-yl)biphenyl-4-carboxamide

The title compound(S)-N-(2-oxoazepan-3-yl)biphenyl-4-carboxamide(C19H20N2O2, Mr = 308.37) was synthesized by the reaction of(S)-α-amino-∑-caprolactam with 4-phenyl-benzoyl chloride. Its chemical structure was determined by 1H NMR, 13 C NMR, H RMS and X-ray single-crystal diffraction. The crystal belongs to the triclinic system, space group P1 with a = 8.2650(17), b = 13.774(3), c = 15.109(3) ?, β = 90.20(3)o, V = 1645.6(6) ?3, Z = 4, Dc = 1.245 g/cm3, μ = 0.081 mm-1, F(000) = 656, R = 0.0756 and w R = 0.1491 for 5964 observed reflections with I 2σ(I). The title compound was also used to prepare polyamide.     

微反应器在合成化学中的应用

微反应器在传质、换热方面具有较明显的优势,可以强化混合和精确控温,还可以大大缩短工艺筛选和工艺放大的周期。 本文着重从液相反应、气相反应和气/液反应3个方面对微反应技术在合成中的应用做了较详细的评述,同时也简略介绍了其在光化学和电化学反应中的应用,并概要介绍了微反应技术现阶段存在的问题。