Effects of Lead on Temporal Response Properties of Retinal Ganglion Cells in Developing Rats

Neonatal rats have taken in lead, during the period from their parturition to their weaning, from the milk of dams fed with water containing 0.2% lead acetate solutions. The alterations in the temporal response properties of retinal ganglion cells in adult rats (90 days) following the lead exposure at their developing stage have been studied. The results of this investigation demonstrate that the lead exposure in neonatal rats causes decreases in the optimal temporal frequency, bandwidth at half amplitude, temporal resolution and response phase of the retinal ganglion cells in adult rats. Compared with the sustained cells, the transient cells have a much greater alteration in temporal response properties.     

铅对海马齿状回L—LTP和双脉冲反应的影响

应用在位电生理技术研究了发育过程中的铅暴露对成年大白鼠海马齿状回超长时程增强（Ｌ－ＬＴＰ）和双脉冲反应（ＰＰＦ）的影响。结果表明，铅使海马神经元ＥＰＳＰ和ＰＳ诱导的Ｌ－ＬＴＰ幅度降低，维持时间缩短，提示铅可能对形成长期记忆中起关键作用的新蛋白合成过程造成损伤。铅使双脉冲易化幅度降低，易化时间宽度变窄，提示铅主要使突触后ＮＭＤＡ受体造成损伤。     

铅对海马神经元通道、受体和递质的影响及作用机制

综述了铅影响儿童学习记忆毒理机制研究的部分进展,即铅对海马神经元通道、受体和递质的影响及作用机制,包括铅对海马突触可塑性,离子通道,对NMDA受体、非NMDA受体及通道特性,神经递质和基因调控的影响。参考文献27篇。