Comparative Molecular Field Analysis （CoMFA） of Curcumin-related Compounds for Anticancer Activity

Three-dimensional （3D） quantitative structure-activity relationship （QSAR） studies of 44 curcumin-related compounds have been carried out based on our previously reported result for their anticancer activity against pancreas cancer Panc-I cells and colon cancer HT-29 cells. The established 3D-QSAR models from the comparative molecular field analysis （CoMFA） in training set showed not only significant statistical quality, but also satisfying predictive ability, with high correlation coefficient values （R12= 0.911, R22= 0.985） and cross-validation coefficient values （q2= 0.580, q22= 0.722）. Based on the CoMFA contour maps, some key structural factors responsible for anticancer activity of these series of compounds were revealed. The results provide some useful theoretical references for understanding the mechanism of action, designing new curcumin-related compounds with anticancer activity and predicting their activities prior to synthesis.     

扫描电子显微镜在鹌鹑蛋壳表征中的应用

利用扫描电子显微镜对鹌鹑蛋蛋壳的横截面、内外表面进行观察,蛋壳由内向外分别是壳膜、乳突层、海绵层、垂直晶体层和角质层. 外表面分布有深褐色、浅黄色的不规则颜色斑点,深褐色区域比浅黄色区域的角质层厚,其差异来自于角质层. 对深褐色区域与浅黄色区域进行外表面能谱分析,深褐色区域的C、O和N元素含量相对高于浅黄色区域,浅黄色区域的Mg、P、S和Ca元素含量相对高于深褐色区域.