Comparative study of pulsed laser diode end-pumped thulium-doped 2-µm Q-switched lasers

We report pulsed laser diode(LD)end-pumped acoustic Q-switched Tm:YAG laser,Tm:LuAG laser,and Tm:LuYAG laser and the physical properties and spectra of Tm:YAG,Tm:LuAG,and Tm:LuYAG are analyzed.The Tm:LuYAG laser is pumped by 785-nm and 788-nm pulses separately,and is compared with Tm:YAG laser.Different output energy values and output wavelengths of Tm:LuAYG lasers pumped by LDs with different wavelengths are obtained and compared with each other.When the repetition frequency is 100 Hz,the pulsed Tm:YAG laser has single pulse energy of 15.9 mJ,pulse width of 126.7 ns,and the center wavelength of 2013.36 nm,and the pulsed Tm:LuAG laser possesses single pulse energy of 11.8 mJ,pulse width of 252.4 ns,and the center wavelength of 2023.65 nm,and the pulsed Tm:LuYAG laser output energy values are 12.32 mJ and 12.25 mJ with the slope efficiencies of 12.5%and 11.85%,the center wavelengths of 2017.89 nm and 2027.11 nm,respectively,while the pump sources are 785-nm and 788-nm pulsed LDs,respectively.     

肿瘤诊疗多肽/聚氨基酸自组装纳米材料

多肽/聚氨基酸分子由于优异的生物相容性、序列可控性和高生物活性等特点，已经被广泛应用于肿瘤诊疗等生物医学领域.然而，这些分子仍然存在一定的缺陷，如光学性质不佳、半衰期短与清除速率快等.本文简述了通过对多肽/聚氨基酸分子的序列设计、侧链修饰和自组装条件进行调控，赋予其可控的光学性质以用于生物成像，更优异的药代动力学和药效学以获得更好的治疗效果.重点介绍了该领域以及本课题组近期关于多肽/聚氨基酸自组装纳米材料的构筑理念及其在肿瘤诊疗领域的应用研究，并对该领域的挑战和未来发展前景进行了展望.