Synthesis and Crystal Structure of 2-Oxo-3-phenyl-1-oxaspiro[4.5]dec-3-en-4-yl 4-chlorobenzoate

The title compound 2-oxo-3-phenyl-1-oxaspiro[4.5]dec-3-en-4-yl 4-chloro-benzoate 6 (C22H19ClO4, Mr = 382.82) has been synthesized by the condensation reaction of 4-hydroxy-3-phenyl-1-oxaspiro[4.5]dec-3-en-2-one 5 with 4-chlorobenzoyl chloride, and its crystal structure was determined by single-crystal X-ray diffraction. The crystal belongs to the monoclinic system, space group P21/n with a = 10.6749(11), b = 6.0573(7), c = 29.680(2) , β = 94.073(3)o, V = 1914.3(3) 3, Z = 4, Dc = 1.328 g/cm3, F(000) = 800, μ = 0.224 mm–1, S = 1.003, the final R = 0.0605 and wR = 0.1500 for 1828 observed reflections with I > 2σ(I) and 244 variable parameters. The crystal analysis shows that the molecular structure of the title compound has one planar furan ring, one chair conformation cyclohexane ring and two benzene rings. The furan and cyclohexane rings adopt whorl conformations.     

药物化学中构效关系的教学方法研究

构效关系是先导化合物修饰、新型药物设计的基础,在药物化学教学中具有至关重要的作用.由于其多样性和复杂性,学生的掌握情况不理想.本文针对这一问题对药物的构效关系进行归纳分类,总结为"三部分一核心多构型"三类,每一类都进行举例讲解,为学生更好地理解与掌握药物化学的构效关系提供一种可行的方式.     

螺环季酮酸衍生物的合成及生物活性研究

为了寻求新颖的螺环季酮酸先导化合物,以3 -(2,4-二氯苯基)-4-羟基-1-氧杂螺[4.5]癸-3-烯-2-酮为原料,合成了21个螺环季酮酸衍生物,其结构经1H NMR,ESI MS和元素分析确认,并测定了化合物6b的晶体结构.初步生物活性测定表明,此类化合物对朱砂叶螨、蚜虫和粘虫都具有很好的生物活性,尤其是化合物5g和5m对朱砂叶螨的LD50分别为35.12和22.39 mg/L,高于螺螨酯的LD50:45.20 mg/L;化合物5b对蚕豆蚜的LD50为21.90 mg/L,而螺螨酯对蚕豆蚜的LD50为174.13 mg/L.     

Synthesis,Crystal Structure and Antitumor Activities of(14S)-2,14-diphenyl-6,6a,11,12-tetrahydro-5H,10H,14H-[1,8]naphthyridino[1,2-c]pyrido[3,2,1-ij] quinazoline-3-carbonitrile

The title compound(14 S)-2,14-diphenyl-6,6 a,11,12-tetrahydro-5 H,10 H,14 H-[1,8] naphthyridino[1,2-c]pyrido[3,2,1-ij]quinazoline-3-carbonitrile(C_(31) H_(26) N_4, M_r = 454.56) has been synthesized with 2-aminonicotinaldehyde and 3-oxo-3-phenylpropanenitrile as starting materials, and its crystal structure was determined by single-crystal X-ray diffraction for the first time. The crystal belongs to the triclinic system, space group P1 with a = 8.5833(8), b = 11.9168(12), c = 14.4424(14) ?, α = 84.208(3)o, β = 88.427(3)o, γ = 73.704(3)o, V = 1410.7(2) ?~3, Z = 2, F(000) = 480, μ = 0.064 mm~(–1), S = 0.966, the final R = 0.0484 and wR = 0.1388 for 5041 observed reflections with I 2s(I) and 316 variable parameters. The preliminary biological tests show that the title compound has a good antitumor activity against K562 in vitro.     

Synthesis,Crystal Structure and Antitumor Activities of 1,2,3,4-Tetrahydroquinoline-2,4-diyl(bisdiphenylphosphine oxide) Derivatives

A novel and efficient Ir-catalyzed 1,4-and 1,2-addition of diphenylphosphine oxide to quinolines was developed to obtain various 1,2,3,4-tetrahydroquinoline-2,4-diyl(bisdiphenylphosphine oxide) derivatives. The structures of these derivatives were characterized by H-RMS and NMR analysis. X-ray crystallography showed that 3 a is in a monoclinic system, space group of P2_1/c with a = 13.0464(16), b = 12.6244(16), c = 20.210(3) ?, β = 105.215(2)o, V =3211.9(7) ?~3, Z = 4, F(000) = 1352, μ = 0.42 mm~(–1), S = 1.07, the final R = 0.059 and wR = 0.195.The in vitro antitumor activities of target compounds were evaluated by MTT assay against human cancer K562, HL-60, HeLa and BGC-823. The target compounds demonstrated weak or moderate antitumor activity against these cell lines.