氟康唑衍生物的设计合成及体外抗真菌活性研究

为了寻找活性更好的抗真菌化合物,基于已有的计算机辅助药物设计结果,保留氟康唑母体结构必需药效团,设计、合成了22个含对甲酚和胸腺嘧啶的氟康唑新衍生物.目标化合物的结构经1H NMR、元素分析和ESI-MS确证,初步体外抗真菌活性试验结果表明,化合物5l对7种真菌都表现出了较好的抗真菌活性(烟曲霉菌除外),化合物5a～5e,5g,5h,7a和7b对不同真菌表现出了一定的抗真菌活性.炔丙基取代氨基侧链结构的引入有利于提高该类目标化合物体外抗真菌活性,值得进一步深入研究.     

黄嘌呤型cPEPCK抑制剂的计算模型建立

通过SYBYL X 2.0软件包中Topomer CoMFA和Surflex-dock研究28种黄嘌呤结构的胞浆型磷酸烯醇式丙酮酸羧激酶(cPEPCK)抑制剂的三维定量构效关系(3D-QSAR)和分子对接模式.所得优化的3D-QSAR模型q2和r~2分别为0.907和0.994(q~20.5时,建立的模型具有可靠的预测能力),结果表明该模型具有较高预测能力.分子对接结果显示,此类分子与cPEPCK的Asn 533,Asn 292和Phe 530等活性功能残基具有氢键作用.Trp516可能是潜在的活性残基.基于以上研究讨论,为设计和开发具有较高活性的新型黄嘌呤类cPEPCK抑制剂提供有效信息.     

系泊海洋平台周期运动倍周期分岔的胞映射分析

应用胞映射方法研究了系泊海洋生产平台的周期运动及其倍周期分岔。系泊运动的数学模型是一个具有指数回复力特性的非线性强迫振子 ,以波浪作用力为外激励。将波浪激励周期作为分岔控制参数 ,研究了周期系泊运动的倍周期分岔。胞映射方法用于寻找系统的稳定吸引子并确定其吸引域。时间历程、相图、功率谱和Poincar啨映射用于确定吸引子的具体类型芯糠⑾?,分岔参数处于不同的区域时 ,系统存在着相异的倍周期分岔特性。观察到了倍周期分岔的产生和突然消失 ,也找到了一个趋于吸引子的倍周期分岔序列。根据吸引域的胞映射分析结果解释了上述不同的倍周期分岔特征。发现其原因在于倍周期序列中的每个吸引子是否具有全局吸引性。     

Advances in chromatographic analysis of ginsenosidesEI北大核心CSCD

Ginsenosides possess pharmacological activities such as anti-aging，cardiovascular protection，and improving immunity. However，the detection and analysis of ginsenosides commonly suffer from the problem of low sensitivity owing to the complex matrix and low content of ginsenosides. Chromatographic technology was often used to detect ginsenosides owing to the advantages of high accuracy，high sensitivity，good reproducibility and low sample consumption，etc. In this review，the application of chromatographic analysis technologies in ginsenosides detection was summarized. First of all，accuracy of test results for the ginsenosides can be effectively improved by using high performance liquid chromatography（HPLC）combined with various detectors. Secondly，the combination of HPLC with mass spectrometry can be utilized for qualitative and quantitative analysis of ginsenosides， as well as other fields， such as metabonomics， pharmacokinetics， intestinal microorganisms and quality control. Moreover，the application of gas chromatography in analysis of ginsenosides was reviewed. Briefly，with the continuous development of chromatographic technology，the degree of accuracy for ginsenosides detection was effectively improved，which is beneficial to realize the effective analysis of ginsenosides. © 2023, Youke Publishing Co., Ltd. All rights reserved.