Surfactant-free cellulose filaments stabilized oil in water emulsions

Cellulose - There has been significant interest over recent years in the production and application of sustainable and green materials. Among these, nanocellulose has incurred great interest...     

LC–UV Assay for Simultaneous Estimation of Aromatic Turmerone, α/β-Turmerone and Curlone: Major Bisabolane Sesquiterpenes of Turmeric Oil in Rabbit Plasma for Application to Pharmacokinetic Studies

The herbal medicament derived from the lipid soluble fraction obtained from Curcuma longa L. (Zingiberaceae) has shown potential neuroprotective activity in disorders like stroke. HM has been standardized with three biomarkers: ar-turmerone, α/β-turmerone and curlone, major bisabolane sesquiterpenes of turmeric oil. Development of a biaonalytical method for these sesquiterpenes was initiated to characterize its preclinical pharmacokinetics in rabbits to accelerate its development as a potential candidate for vascular complications. Since, the compounds are structurally and chemically very similar, gradient elution was utilized on a C-18 reversed phase column with a mobile phase comprising of acetonitrile and deionised water. The UV detector was set at wavelengths 240 and 270 nm. The sample clean-up was performed by protein precipitation with acetonitrile. The method was reasonably sensitive with limits of quantitation (LOQ) of 0.098 μg mL^?1 in plasma for all the analytes. Accuracy and precision were within the acceptable limits, as indicated by relative standard deviation (% RSD) varying from 1.3 to 13.6% and bias values ranging from ?5.5 to 10.3%, respectively. Moreover, the analytes were stable in plasma even after three freeze-thaw cycles. The method was applied to generate preliminary pharmacokinetics of turmeric oil in rabbits after intravenous administration.     

An algorithm for constrained convex optimization

This paper presents a feasible direction algorithm for the minimization of a pseudoconvex function over a smooth, compact, convex set. We establish that each cluster point of the generated sequence is an optimal solution of the problem without introducing anti-jamming procedures. Each iteration of the algorithm involves as subproblems only one line search for a zero of a continuously differentiable convex function and one univariate function minimization on a compact interval.     

In vitro antioxidant activities of the methanol extract and its different solvent fractions obtained from the fruit pericarp of Terminalia bellerica

Terminalia bellerica has been used as a traditional medicine in a variety of ailments including anaemia, asthma, cancer, inflammation, rheumatism and hypertension. In this study, the free radical scavenging and antioxidant activities of methanol extract (ME) and its different solvent fractions (namely hexane (HE), ethyl acetate (EA), butanol (BL) and water (WA)) of the T. bellerica fruit pericarp were evaluated and compared with standard antioxidant compounds like gallic acid (GA), catechin and ascorbic acid. Among the different fractions tested, the EA fraction exhibited higher antioxidant and radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide and hydroxyl radicals than the other fractions, which may be attributed to its higher phenolic and flavonoid content, since a linear relation was observed between the phenolic content and the antioxidant parameters. The HPTLC analysis of the EA fraction revealed that it mainly contains GA and ferulic acid (FA) as major phenolics, and the higher antioxidant activities of EA fraction may be due to the presence of these compounds.     

In vitro antiperoxidative, free radical scavenging and xanthine oxidase inhibitory potentials of ethyl acetate fraction of Saraca ashoka flowers

Saraca ashoka is a widely used medicinal herb claimed to cure many diseases. This study investigated the antiperoxidative, free radical scavenging and xanthine oxidase (XO) inhibitory potential of the ethyl acetate fraction of S. ashoka flowers (SAF) and compared it with standard compounds like gallic acid, ascorbic acid, butylated hydroxyl toluene and allopurinol. The ethyl acetate fraction of SAF exhibited free radical scavenging activity against the 1,1-diphenyl-2-picrylhydrazyl radical and superoxide radical, along with hydroxyl radical scavenging activity. Lipid peroxidation inhibitory potential of SAF was studied using a linoleic acid emulsion system, which shows significant antioxidant potential. SAF also demonstrated significant XO (key enzyme linked to inflammation) inhibitory activity, which revealed its therapeutic potential as an antioxidant and XO inhibitor. HPLC profiling of the ethyl acetate fraction of SAF revealed that it contains ellagic acid as a major compound and thus the beneficial effects of this fraction may be due to the presence of this compound.     

Theorems of the Alternative and Duality

This paper investigates the relations between theorems of the alternative and the minimum norm duality theorem. A typical theorem of the alternative is associated with two systems of linear inequalities and/or equalities, a primal system and a dual one, asserting that either the primal system has a solution, or the dual system has a solution, but never both. On the other hand, the minimum norm duality theorem says that the minimum distance from a given point z to a convex set is equal to the maximum of the distances from z to the hyperplanes separating z and . We consider the theorems of Farkas, Gale, Gordan, and Motzkin, as well as new theorems that characterize the optimality conditions of discrete l ₁-approximation problems and multifacility location problems. It is shown that, with proper choices of , each of these theorems can be recast as a pair of dual problems: a primal steepest descent problem that resembles the original primal system, and a dual least–norm problem that resembles the original dual system. The norm that defines the least-norm problem is the dual norm with respect to that which defines the steepest descent problem. Moreover, let y solve the least norm problem and let r denote the corresponding residual vector. If r=0, which means that z , then y solves the dual system. Otherwise, when r0 and z , any dual vector of r solves both the steepest descent problem and the primal system. In other words, let x solve the steepest descent problem; then, r and x are aligned. These results hold for any norm on . If the norm is smooth and strictly convex, then there are explicit rules for retrieving x from r and vice versa.     

A novel electron-transfer mediated reaction leading to lepidopterene

(Anthracen-9-yl)methanamines were found to undergo single electron-transfer mediated C-N bond cleavage in the presence of excess dimethyl acetylenedicarboxylate (DMAD) in non-polar solvents leading to the formation of lepidopterene (4) and 1,2-bis(9-anthracenyl)ethane (3). The structure of lepidopterene was confirmed on the basis of NMR data and by X-ray crystallography.     

Ene-Reductase: A Multifaceted Biocatalyst in Organic Synthesis

Biocatalysis integrate microbiologists, enzymologists, and organic chemists to access the repertoire of pharmaceutical and agrochemicals with high chemoselectivity, regioselectivity, and enantioselectivity. The saturation of carbon-carbon double bonds by biocatalysts challenges the conventional chemical methodology as it bypasses the use of precious metals (in combination with chiral ligands and molecular hydrogen) or organocatalysts. In this line, Ene-reductases (ERs) from the Old Yellow Enzymes (OYEs) family are found to be a prominent asymmetric biocatalyst that is increasingly used in academia and industries towards unparalleled stereoselective trans-hydrogenations of activated C=C bonds. ERs gained prominence as they were used as individual catalysts, multi-enzyme cascades, and in conjugation with chemical reagents (chemoenzymatic approach). Besides, ERs’ participation in the photoelectrochemical and radical-mediated process helps to unlock many scopes outside traditional biocatalysis. These up-and-coming methodologies entice the enzymologists and chemists to explore, expand and harness the chemistries displayed by ERs for industrial settings. Herein, we reviewed the last five year's exploration of organic transformations using ERs.