Transient displacement induced in shear wave elastography: comparison between analytical results and ultrasound measurements

It is now accepted that an effective way to investigate the elastic properties of soft tissues is to generate a localized transient acoustic radiation force and to follow the associated displacements in the time/space domain. Shear waves induced by this stress field are particularly interesting in this kind of medium because they are governed by the shear elastic modulus mu, which is directly linked to the Young modulus, and spatial distribution and temporal evolution of the transient motion induced must therefore be obtained in detail. We report here a model based on the elastodynamic Green's function formalism to describe these displacements. 3D simulation of radiation force in homogenous elastic media was performed and the displacement curves computed at different radial distances for different temporal force profiles. Amplitude and duration of displacement were found to be reliable parameters to characterize the elastic properties of the medium. Experimental measurements were performed in a homogeneous agar-gelatin tissue-mimicking phantom, and two transducers were used to generate the radiation force and follow the induced displacements. Displacements obtained from different lateral locations around the applied force axis were then used to reconstruct the shear-wave propagation in a scan plane as a function of time. The experimental displacements/curves agreed with the theoretical profiles obtained by the elastodynamic Green's function formalism.     

Non-linear acoustic measurements to assess crack density in trabecular bone

Three methods to measure qualitative and quantitative aspects of bone non-linearity were investigated in the context of diagnosis of bone “biomechanical health”: i.e. harmonic generation, parametric emission and parametric reception using phase modulation. Trabecular bone exhibited hysteretic non-linear behavior due to microcracks in bone tissue, and parametric reception using phase modulation seemed to be the best configuration for in vivo application. However, the relationship between level of non-linearity and crack density needs to be validated by histological analysis.     

Presence of nonlinear interference effects as a source of low frequency excitation force in vibro-acoustography

The vibro-acoustography imaging method consists of forming an image of the deformability of a tissue submitted to a low frequency fLF stress field. This sound field can be created locally by means of a focused annular array emitting two primary beams driven at two close frequencies fa and fb = fa + fLF. In the existing literature, the origin of this stress field has been identified as the low frequency radiation pressure of the two primary beams. However, this work intends to show that another contribution to this internal stress is the low frequency field distributed in the object volume and created by the nonlinear interferences of the two primary beams. This nonlinear field was calculated in the case of multiple ring annular arrays and compared with the qLF beam experimentally measured in a water tank. The agreement between the theoretical and experimental curves provides information on the possibility that this nonlinear effect takes place in vibro-acoustography.     

Influence of acousto-optic interactions on the determination of the diffracted field by an array obtained from displacement measurements

This paper deals with the influence of acousto-optic interactions on the displacement measurements performed over transducer array and their effects on the predicted diffraction field. Changes on the temporal/spatial responses and the plane wave decomposition of the displacement are discussed. Modifications made on the directivity pattern are shown. A theoretical analysis of acousto-optic phenomenon, based on the plane wave decomposition of radiated field by the array is developed. Theoretical and experimental results are compared, showing first that waves with phase velocity near the one of the fluid are greatly amplified. Second, the interaction of laser beam with edge wave produced by the vertical size of elements induces a parasitic temporal pulse on the x-t diagram and so an interference pattern in the omega-k diagram. Corrections are proposed to eliminate errors induced by acousto-optic interactions and validated by comparing predicted diffraction field with measurements.     

Time-domain modeling of nonlinear distortion of pulsed finite amplitude sound beams

This work aims to validate a time domain numerical model for the nonlinear propagation of a short pulse of finite amplitude sound beam propagation in a tissue-mimicking liquid. The complete evolution equation is simply derived by a superposition of elementary operators corresponding to the 'one effect equation'. Diffraction LD, absorption and dispersion LAD, and nonlinear distortion LNL effects are treated independently using a first order operator-splitting algorithm. Using the method of fractional steps, the normal particle velocity and the acoustical pressure are calculated plane by plane, at each point of a two-dimensional spatial grid, from the surface of the plane circular transducer to a specified distance. The LA operator is a time convolution between the particle velocity and the causal attenuation filter built after the Kramers-Kroning relations. The LNL operator is a time-based transformation obtained by following an implicit Poisson analytic solution. The LD operator is the usual Rayleigh integral. We present a comparison between theoretical and experimental temporal pressure waveform and axial pressure curves for fundamental (2.25 MHz), second, third and fourth harmonics, obtained after spectral analysis.     

Study of structural and electronic transport properties of Ce-doped LaMnO3

The structural and electronic transport properties of La_1−x Ce _x MnO₃ (x=0.0–1.0) have been studied. All the samples exhibit orthorhombic crystal symmetry and the unit cell volume decreases with Ce doping. They also make a metal-insulator transition (MIT) and transition temperature increases with increase in Ce concentration up to 50% doping. The system La_0.5Ce_0.5MnO₃ also exhibits MIT instead of charge-ordered state as observed in the hole doped systems of the same composition.     

Temporal analysis of tissue displacement induced by a transient ultrasound radiation force

One of the stress sources that can be used in dynamic elastography imaging methods is the acoustic radiation force. However, displacements of the medium induced by this stress field are generally not fully understood in terms of spatial distribution and temporal evolution. A model has been developed based on the elastodynamic Green's function describing the different acoustic waves generated by focused ultrasound. The function is composed of three terms: two far-field terms, which correspond to a purely longitudinal compression wave and a purely transverse shear wave, and a coupling near-field term which has a longitudinal component and a transverse component. For propagation distances in the shear wavelength range, the predominant term is the near field term. The displacement duration corresponds to the propagation duration of the shear wave between the farthest source point and the observation point. This time therefore depends on the source size and the local shear modulus of the tissue. Evolution of the displacement/time curve profile, which is directly linked to spatial and temporal source profiles, is computed at different radial distances, for different durations of force applications and different shear elastic coefficients. Experimental results performed with an optical interferometric method in a homogeneous tissue-mimicking phantom agreed with the theoretical profiles.