Preliminary design of high-power wave-guide/transmission system for multimegawatt CW requirements of 100 MeV proton LINAC

Development of a 100 MeV CW proton LINAC has been planned at CAT. This LINAC will be needing CW rf power in the frequency ranges of 350 MHz and 700 MHz for its RFQ and DTL/CCDTL/SFDTL structures respectively. The power to the accelerating structures will be produced by either 1 MW CW or 250 kW CW klystrons/inductive output tubes (HOM IOTs). The power needed by respective feed points in the structure is max. 250 kW which will be powered by splitting the power from 1 MW klystron/klystrode into four channels by using a wave-guide system. In case of using 250 kW tubes the power to the structures will be provided directly from each tube. Two types of wave-guide transmission system have been considered, viz, WR 2300 for 350 MHz rf needs and WR 1500 for 700 MHz rf needs. The typical wave-guide system has been designed using the 1 MW CW klystron followed by wave-guide filter, dual directional coupler, high-power circulator, three 3 dB magic TEE power dividers to split the main channel into four equal channels of 250 kW each. Each individual channel has dual directional couplers, flexible wave-guide sections and high power ceramic vacuum window. The circulator and each power divider is terminated into the isolated ports by high power CW loads. Out of the four channels three channels have phase shifters. Present paper describes the technological aspects and design specifications-considerations for these stringent requirements.     

A rapid chromatographic method for the estimation of thorium in rocks, soils and low grade ores

Summary A simple and rapid field Chromatographic method for the determination of thorium in ppm quantities in rocks, soils and low grade ores using paper strip chromatography is described. An aliquot of an hydrochloric acid solution of the sample is taken on a special paper (Chromatographic paper of C.R.L./l grade) and the paper is then placed into a beaker containing the solvent mixture consisting of methyl alcohol, acetone, 2-thenoyl trifluoroacetone and hydrochloric acid in the ratio 12 ml6 ml0.04 g2 ml (13) respectively.A saturated alcoholic solution of alizarin atph 2.8-2.4 is used as developing reagent.This method is applicable to samples containing from 0.2 ppm to 1000 ppm of thorium.

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Zusammenfassung Eine einfache und schnell durchführbare Feldmethode zur papierchromatographischen Bestimmung von ppm-Mengen Thorium in Gesteinen, Böden und Erzen niederen Gehaltes wird beschrieben. Hierbei wird ein Anteil der salzsauren Probelösung auf ein Spezialpapier (C.R.L./ 1 grade) aufgebracht und dieses in einem Becherglas mit einem Gemisch aus Methanol, Aceton, 2-Thenoxyltrifluoraceton und Salzsäure (12 ml 6 ml0,04 g2 ml [13]) chromatographiert. Zur Entwicklung dient eine gesättigte alkoholische Alizarinlösung (ph 2,8-2,4). 0,2–1000 ppm Thorium können nach diesen Verfahren bestimmt werden.

     

Near-barrier fission of the system12C+232Th

The fission fragment angular distributions for the system¹²C +²³²Th have been measured in the energy range 0.97<>_c.m./V_B<1.22. the=" measured=" anisotropies=" have=" been=" compared=" with=" the=" predictions=" of=" the=" standard=" saddle=" point=" statistical=" model,=" using=" the=" second=" moment=" of=" the=" compound=" nucleus=" spin=" distribution=">l² deduced from a Wong model fit to the fission excitation function. While the measured anisotropies agree with the standard saddle point statistical model for E_c.m./V_B>1.05, they are abnormally large at lower energies. This is also true for the existing measurements of¹⁶O and¹⁹F +²³²Th systems. Since for this system pre-equilibrium fission contributions are not expected, this anomaly indicates strong channel coupling effects leading to an increase in l² at sub-barrier energies.The authors thank Drs. R.K. Choudhury and A. Saxena for useful discussions, Dr. R.J. Singh for making the thorium target and the Pellectron operation staff for excellent operation of the machine.     

A single amino acid Gly-tag enables metal-free protein purification

Analytically pure proteins are indispensable for diverse applications, including therapeutics. Here, we report a methodology where a single amino acid, glycine, enables metal-free protein purification. This robust platform is enabled by a Gly-tag resin for site-specific capture, enrichment, and release through chemically triggered C–C bond dissociation by resonance-assisted electron density polarization.

Gly-tag resin precisely captures and releases a protein with one glycine at the N-terminus. The user-friendly protocol delivers analytically pure protein free of metal contaminants.     

Spectroscopic studies on the mode of interaction of an anticancer drug with bovine serum albumin

The mechanism of interaction of vinblastin sulphate (VBS) with bovine serum albumin (BSA) has been reported. Association constant for VBS-BSA binding was found to be 3.146+/-0.06 x 10(4) M(-1). Stern-Volmer analysis of fluorescence quenching data showed that the fraction of fluorophore (protein) accessible to the quencher (drug) was close to unity indicating thereby that both tryptophan residues of BSA are involved in drug-protein interaction. The rate constant for quenching, greater than 10(10) M(-1) S(-1), indicated that the drug-binding site is in close proximity to tryptophan residues of BSA. Binding studies in the presence of an hydrophobic probe, 8-anilino-1-naphthalein-sulphonic acid, sodium salt (ANS) indicated that there is hydrophobic interaction between VBS and probe and they do not share common sites in BSA. Thermodynamic parameters obtained from data at different temperatures showed that the binding of VBS to BSA involves predominant hydrophobic forces. The effects of some additives and paracetamol on binding of VBS-BSA have also been investigated. The CD spectrum of BSA in presence of VBS shows that the binding of VBS leads to change in the helicity of BSA.     

Micro Scale Procedure for Analysis of Andrographolide in Andrographis paniculata Leaves

JPC – Journal of Planar Chromatography – Modern TLC - A high-performance thin-layer chromatographic (HPTLC) method has been established for quantitative analysis of andrographolide, the...     

Thermal analysis of interaction between 2-PAM chloride and various excipients in some binary mixtures by TGA and DSC

Pralidoxime chloride known as 2-PAM chloride is used as antidote for nerve agent’s poisoning. This study was undertaken to establish the compatibility of 2-PAM chloride with a number of commonly used excipients by using thermoanalytical technique viz., differential scanning calorimetry (DSC) and thermogravimetry/differential thermogravimetry (TG/DTG) used in pharmaceutical formulation. The TG and DSC both results demonstrated that polyvinyl alcohol, polyacrylamide, microcrestline cellulose, hydroxypropyl cellulose, cellulose acetate, ethyl cellulose found to be compatible with 2-PAM chloride and chosen for the preparation of antidote against chemical warfare agents.     

Kinetics and thermoluminescence glow curve study of Ba2MgSi2O7:Eu3+, Dy3+

This paper reports thermoluminescence glow curves of Eu³⁺, Dy³⁺-doped Ba₂MgSi₂O₇ phosphor for different UV exposure times. Kinetic data were evaluated by the peak-shape method. The glow curves shift toward higher intensity with increasing exposure time to UV at 365 nm. When the heating rate was 5 °C s^?1, peaks were observed at 101.76, 109.69, 102.67, and 104.05 °C, respectively, after UV exposure for 5, 10, 15, and 20 min. The glow peaks are indicative of second-order kinetics. Different kinetic data, i.e. trap depth, order of kinetics, activation energy, and frequency factor were also calculated. To evaluate the persistence characteristics of the luminescence of the phosphor, the lifetime of the charge in the trap was calculated; it was 348, 660, 368, and 428 s for UV exposure of 5, 10, 15, and 20 min, which indicates the luminescence of the phosphor is persistent.     

Calix[4]arene-based ditopic receptors for simultaneous recognition of fluoride and cobalt(II) ions

A series of calix[4]arene based ditopic receptors possessing bipyridyl and hydrazone units have been synthesized and evaluated for ionic recognition. It has been observed that the synthesized derivatives function as allosteric receptors for simultaneous recognition of Co²⁺and F^? ions through non-covalent interactions. Significant bathochromic shifts in the UV–visible spectrum with a profound colour change promise their use to engineer novel applications.     

Ion beam synthesis of metal-quantum dots for photonic applications

Although electronics technologies have made great advances in device speed, optical devices can function in the time domain inaccessible to electronics. In the time domain less than 1 ps, optical devices have no competition. Photonic or optical devices are designed to switch and process light signals without converting them to electronic form. The major advantages that these devices offer are speed and preservation of bandwidth. The switching is accomplished through changes in refractive index of the material that are proportional to the light intensity. The third-order optical susceptibility, χ⁽³⁾, known as the optical Kerr susceptibility which is related to the non-linear part of the total refractive index, is the nonlinearity which provides this particular feature. Future opportunities in photonic switching and information processing will depend critically on the development of improved photonic materials with enhanced Kerr susceptibilities, as these materials are still in a relatively early stage of development. Different glass systems are now under investigation to increase their nonlinearity by introducing a variety of modifiers into the glass-network. Ion implantation is an attractive method for inducing colloid formation at a high local concentration unattainable by the melt-glass fabrication process and for confining the non-linearities to specific patterned regions in a variety of host matrices. Recent works on metal-ion implanted colloid generation in bulk fused silica glasses have shown that these nanocluster-glass composites under favourable circumstances have significant enhancement of χ⁽³⁾ with picosecond to femtosecond temporal responses.