排序方式: 共有6条查询结果,搜索用时 140 毫秒
1
1.
Yang VX Munce N Pekar J Gordon ML Lo S Marcon NE Wilson BC Vitkin IA 《Optics letters》2004,29(15):1754-1756
High-resolution optical coherence tomography demands a large detector bandwidth and a high numerical aperture for real-time imaging, which is difficult to achieve over a large imaging depth. To resolve these conflicting requirements we propose a novel multifocus fiber-based optical coherence tomography system with a micromachined array tip. We demonstrate the fabrication of a prototype four-channel tip that maintains a 9-14-microm spot diameter with more than 500 microm of imaging depth. Images of a resolution target and a human tooth were obtained with this tip by use of a four-channel cascaded Michelson fiber-optic interferometer, scanned simultaneously at 8 kHz with geometric power distribution across the four channels. 相似文献
2.
Yang VX Mao YX Munce N Standish B Kucharczyk W Marcon NE Wilson BC Vitkin IA 《Optics letters》2005,30(14):1791-1793
Doppler optical coherence tomography (OCT) can image tissue structure and blood flow at micrometer-scale resolution but has limited imaging depth. We report a novel, linear-scanning, needle-based Doppler OCT system using angle-polished gradient-index or ball-lensed fibers. A prototype system with a 19-guage (diameter of approximately 0.9 mm) echogenic needle is constructed and demonstrates in vivo imaging of bidirectional blood flow in rat leg and abdominal cavity. To our knowledge, this is the first demonstration of Doppler OCT through a needle probe in interstitial applications to visualize deeply situated microcirculation. 相似文献
3.
Munce NR Mariampillai A Standish BA Pop M Anderson KJ Liu GY Luk T Courtney BK Wright GA Vitkin IA Yang VX 《Optics letters》2008,33(7):657-659
A novel flexible scanning optical probe is constructed with a finely etched optical fiber strung through a platinum coil in the lumen of a dissipative polymer. The packaged probe is 2.2 mm in diameter with a rigid length of 6mm when using a ball lens or 12 mm when scanning the fiber proximal to a gradient-index (GRIN) lens. Driven by constant high voltage (1-3 kV) at low current (< 5 microA), the probe oscillates to provide wide forward-viewing angle (13 degrees and 33 degrees with ball and GRIN lens designs, respectively) and high-frame-rate (10-140 fps) operation. Motion of the probe tip is observed with a high-speed camera and compared with theory. Optical coherence tomography (OCT) imaging with the probe is demonstrated with a wavelength-swept source laser. Images of an IR card as well as in vivo Doppler OCT images of a tadpole heart are presented. This optomechanical design offers a simple, inexpensive method to obtain a high-frame-rate forward-viewing scanning probe. 相似文献
4.
Johnson ER; McDonald NR 《The Quarterly Journal of Mechanics and Applied Mathematics》2007,60(1):65-72
An explicit solution for a layer of fluid with constant vorticitysurrounding a thin plate of finite length is obtained usingelementary conformal mapping methods. In the limit of largeplate length the behaviour of the solution near the ends ofthe plate tends to that of the previously known solution fora semi-infinite plate. Contour dynamics is used to investigatethe stability of the steady solutions. 相似文献
5.
Yang VX Mao Y Standish BA Munce NR Chiu S Burnes D Wilson BC Vitkin IA Himmer PA Dickensheets DL 《Optics letters》2006,31(9):1262-1264
An elliptical microelectromechanical system (MEMS) membrane mirror is electrostatically actuated to dynamically adjust the optical beam focus and track the axial scanning of the coherence gate in a Doppler optical coherence tomography (DOCT) system at 8 kHz. The MEMS mirror is designed to maintain a constant numerical aperture of approximately 0.13 and a spot size of approximately 6.7 microm over an imaging depth of 1mm in water, which improves imaging performance in resolving microspheres in gel samples and Doppler shift estimation precision in a flow phantom. The mirror's small size (1.4 mm x 1 mm) will allow integration with endoscopic MEMS-DOCT for in vivo applications. 相似文献
6.
Speckle variance detection of microvasculature using swept-source optical coherence tomography 总被引:1,自引:0,他引:1
Mariampillai A Standish BA Moriyama EH Khurana M Munce NR Leung MK Jiang J Cable A Wilson BC Vitkin IA Yang VX 《Optics letters》2008,33(13):1530-1532
We report on imaging of microcirculation by calculating the speckle variance of optical coherence tomography (OCT) structural images acquired using a Fourier domain mode-locked swept-wavelength laser. The algorithm calculates interframe speckle variance in two-dimensional and three-dimensional OCT data sets and shows little dependence to the Doppler angle ranging from 75 degrees to 90 degrees . We demonstrate in vivo detection of blood flow in vessels as small as 25 microm in diameter in a dorsal skinfold window chamber model with direct comparison with intravital fluorescence confocal microscopy. This technique can visualize vessel-size-dependent vascular shutdown and transient vascular occlusion during Visudyne photodynamic therapy and may provide opportunities for studying therapeutic effects of antivascular treatments without on exogenous contrast agent. 相似文献
1