镍中氢与缺陷互作用的正电子寿命和多普勒展宽研究

采用正电子寿命和多普勒展宽技术研究了退火、回复及冷轧镍中氢与缺陷的互作用．结果表明：冷轧镍充氢后正电子平均寿命和多普勒展宽S参数上升，并且寿命谱的两成分拟合出现一个390ps的长寿命分量；而退火及回复镍充氢后正电子平均寿命和多普勒展宽S参数均不改变．因此认为冷轧镍充氢后正电子参数（平均寿命和S参数）的上升取决于氢和空位的互作用，与氢和位错的互作用无关；氢空位对也可以作为聚集空位的核心 关键词：     

Synthesis of the proposed structure of plakevulin A: revised structure of plakevulin A

A total synthesis of the proposed structure of plakevulin A was accomplished. However, the NMR spectral data of the synthetic plakevulin A were not identical of those of the reported compound. We next converted the synthetic plakevulin A into 1-dihydrountenone A. The ¹H and ¹³C NMR spectral data of 1-dihydrountenone A were identical with those of reported plakevulin A except for the peaks derived from levulinic acid. Thus, we repurified sample of the natural product and confirmed that the natural sample contained 1-dihydrountenone A and levulinic acid in the ratio of one to one. We also found that not plakevulin A but 1-dihydountenone A possessed the inhibitory activity against mammalian DNA polymerases α and β.     

SINGLE AND DOUBLE EDGE INTERFACE CRACK SOLUTIONS FOR ARBITRARY FORMS OF MATERIAL COMBINATION

In this paper interfacial edge crack problems are considered by the application of the finite element method. The stress intensity factors are accurately determined from the ratio of crack-tip-stress value between the target given unknown and reference problems. The reference problem is chosen to produce the singular stress fields proportional to those of the given unknown problem. Here the original proportional method is improved through utilizing very refined meshes and post-processing technique of linear extrapolation. The results for a double-edge interface crack in a bonded strip are newly obtained and compared with those of a single-edge interface crack for different forms of combination of material. It is found that the stress intensity factors should be compared in the three different zones of relative crack lengths. Different from the case of a cracked homogeneous strip, the results for the double edge interface cracks are found to possibly be bigger than those for a single edge interface crack under the same relative crack length.     

A Nonenzymatic Kinetic Resolution of (±)-trans-2-Arylcyclohexanols via Esterification Using Polymer-Supported DCC,DMAP, and 3β-Acetoxyetienic Acid

A nonenzymatic kinetic resolution of (±)-trans-2-arylcyclohexanols was carried out by esterification using polymer-supported N,N′-dicyclohexylcarbodiimide (DCC), dimethylaminopyridine (DMAP), and 3β-acetoxyetienic acid. The efficiency of the kinetic resolution was comparable to the enzymatic method when arylcyclohexanols bearing a condensed-aromatic ring were used.

Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communication® to view the free supplemental file.     

An Alumanylyttrium Complex with an Absorption due to a Transition from the Al−Y Bond to an Unoccupied d-Orbital

The reaction between a dialkyl-substituted alumanyl anion and [Y(CH₂SiMe₃)₂(thf)₃][BPh₄] resulted in the formation of (dialkylalumanyl)yttrium complex 2 , which exhibits the first 2-center–2-electron (2 c-2 e) Al−Y bond. The ¹H and ¹³C NMR spectra of 2 together with an X-ray crystallographic analysis indicated a C_2v symmetrical structure. DFT calculations on 2 revealed that its LUMO consists of overlapping 3 p- and 4 d-orbitals of the Al and Y atoms, respectively, and that the HOMO–LUMO gap is narrow. The UV/Vis spectrum of 2 exhibited a visible absorption at 432 nm, which suggests that the strong σ-donating and π-accepting character of the three-coordinate dialkylalumanyl ligand generates a colored d⁰-complex that does not contain any π-electrons.     

Single-Step N-Terminal Modification of Proteins via a Bio-Inspired Copper(II)-Mediated Aldol Reaction

The chemical modification of proteins is an effective technique for manipulating the properties and functions of proteins, and for creating protein-based materials. The N-terminus is a promising target for single-site modification that provides modified proteins with uniform structures and properties. In this paper, a copper(II)-mediated aldol reaction with 2-pyridinecarboxaldehyde (2-PC) derivatives is proposed as an operationally simple method to selectively modify the N-terminus of peptides and proteins at room temperature and physiological pH. The copper(II) ion activates the N-terminal amino acids by complexation with an imine of the N-terminal amino acid and 2-PCs, realizing the selective formation of the nucleophilic intermediate at the N-terminus. This results in a stable carbon-carbon bond between the 2-PCs and the α-carbon of various N-terminal amino acids. The reaction is applied to four different proteins, including biopharmaceuticals such as filgrastim and trastuzumab. The modified trastuzumab retains the human epidermal growth factor receptor 2 recognition activity.     

Linear Multiselenium Interactions in Dicationic Oligomers of 1,5‐(Diselena)canes: Behavior of Semc σ(mcc‐nee) (6≤mc≤16) Elucidated with QTAIM Dual Functional Analysis

Invited for this month''s cover picture is the group of Dr. Satoko Hayashi at Faculty of Systems Engineering and Chemistry at Wakayama University. The cover picture shows the linear Se₁₆ σ(16c–30e) interactions, illustrated by the molecular graph type on the optimized structure of the dicationic octamer of 1,5‐(diselena)cane. HOMO‐1 of ψ₄₆₂ is drawn on the structure, which is located predominantly on the Se atoms. The optimized structure is stable, due to the nice engagement between the (CH₂)₃ moieties. The contour maps of ρ(r) are also drawn on the molecular C _s planes of the dicationic dimer and trimer to demonstrate clearly the existence of the interactions between Se atoms. Read the full text of their Full Paper at 10.1002/open.202100017.

“… To improve the causality of experimental results, we have proposed a new concept, called “Keisan‐sendo…” Find out more about the story behind the front cover research at 10.1002/open.202100017.     

Preparation and properties of a fullerene/polysiloxane hybrid from chemically modified fullerene and polymethoxysiloxane

An organic–inorganic hybrid was prepared by simply mixing a fullerene derivative with polymethoxysiloxane. First, C₆₀ was subjected to a radical addition reaction with 4,4′-azobis(4-cyanovaleric acid) to provide a C₆₀ derivative. Polymethoxysiloxane was prepared by a controlled hydrolytic condensation of tetramethoxysilane. These two compounds were mixed and heated to provide hybrid bulk body. The hybrid bulk body showed high mechanical strength and elastic modulus compared with polymethoxysiloxane or the C₆₀/polymethoxysiloxane hybrid. The formation of a dense siloxane network was established by a homogeneous mixing of the C₆₀ derivative with polymethoxysiloxane.