高压电场作用下乙醇-水溶液体系变化红外光谱分析

本文报道了用红外光谱分析电磁场作用下乙醇 水溶液体系变化情况。分析结果表明 :当乙醇溶液受到 2 0kV·cm- 1 的交变电磁场处理 (5 0Hz)时 ,分子之间的氢键缔合先增大后减少 ;高乙醇含量溶液受到同样强度电场较长时间处理时 ,有乙醇发生氧化反应 ,从红外谱中可看到νCO 峰及ν(OH) (H2 O) 峰的出现 ;经处理后的溶液自然放置 7天再测定 ,其红外谱图基本保持不变。文中对各出现变化的峰进行了分析 ,并对其机理进行了推导     

Synthesis and Characterization of a Novel Biomaterial： Maleic Anhydride-modified Poly（dl-lactic acid）

A novel modified poly(dl-lactic acid) (PDLLA) was obtained by covalently grafting of maleic anhydride onto the backbone of PDLLA, attempting to improve PDLLA‘s hydrophilicity and cell affinity and to provide reactive groups for further chemical modification. FTIR, ^13 C NMR and DSC were used to characterize the maleic anhydride-modified PDLLA.     

弱酸树脂D113对S-腺苷-L-蛋氨酸的交换行为及分离应用研究

考察了S-腺苷-L-蛋氨酸 (S-adenosyl-L-methionine, SAM) 在弱酸树脂争光D113上的静态吸附及分离行为,利用Langmuir等温式对平衡等温线进行了拟合,实验表明,随着pH的提高,平衡交换量增加,提高温度和SAM的初始浓度在一定程度上能促进内扩散过程,利用D113树脂在f 1.7×30.0cm小型柱上从酵母提取液中分离SAM的得率为90%以上,纯度达87%以上。     

Nanocatalytic resonance scattering spectral analysis

The resonance scattering spectral technique has been established using the synchronous scanning technique on spectrofluorometry.Because of its advantages of simplicity,rapidity and sensitivity,it has been widely applied to analyses of proteins,nucleic acids and inorganic ions.This paper summarizes the application of immunonanogold and aptamer modified nanogold(AptAu) catalytic resonance scattering spectral technique in combination with the work of our group,citing 53 references.     

QUANTITATIVE EXPLANATION ON STRUCTURE-CARCINOGENIC ACTIVITY RELATIONSHIP OF AROMATIC AMINES BY DI-REGION THEORY

Di-region theory, the theory for the mechanism of carcinogenesis, has been extendedsuccessfully on the quantitative Structure-carcinogenic activity relationship (QSCAR) of 63aromatic amines. A quantitative equation for the QSCAR of aromatic amines has been estab-lished by the mechanism conception of the specialized di- functional alkylation between thenitrenium ion of the amino group and the epoxide of the aromatic ring. The agreementbetween calculation and experiment comes up to 98%. Thus, it can now express the puzzlingvariation of the carcinogenicity of aromatic amines, as a comprehensible structure-chemicalreactivity relationship.     

二芳基三嗪类HIV-1逆转录酶抑制剂的分子对接及3D-QSAR研究

对40个二芳基三嗪类HIV-1逆转录酶抑制剂进行了分子对接研究,结果表明,2个疏水性芳香取代基团与结合口袋底部形成的疏水和范德华相互作用、三嗪环母核及其R4取代基与结合位点产生的氢键和静电作用以及R4取代基与袋口形成的空间位阻效应是影响该系列化合物活性的重要因素.根据对接优势构象进行分子叠合和比较分子相似性指数分析(C...     

Recent progress in the application of microfluidic systems and gold nanoparticles in immunoassays

Immunoassays are useful for many bioassays. Many new techniques and materials are introduced into the immunoassay to improve the efficiency. This paper reviews recent progress in the application of microfluidic systems and gold nanoparticles in immunoassay. The micro/nano technologies and materials can offer good sensitivity, fast detection, cost-effectiveness and easy signal readout. In particular, the miniaturization of microfluidics and colorimetric assays based on gold nanoparticles have dramatically im...     

An atomic electronegative distance vector and carbon-13 nuclear magnetic resonance chemical shifts of alcohols and alkanes

A novel atomic electronegative distance vector (AEDV) has been developed to express the chemical environment of various chemically equivalent carbon atoms in alcohols and alkanes. Combining AEDV and Y parameter, four five-parameter linear relationship equations of chemical shift for four types of carbon atoms are created by using multiple linear regression. Correlation coefficients are R = 0.9887, 0.9972, 0.9978 and 0.9968 and roots of mean square error are RMS = 0.906, 0. 821, 1.091 and 1.091 of four types of carbons, i.e., type 1, 2, 3, and 4 for primary, secondary, tertiary, and quaternary carbons, respectively. The stability and prediction capacity for external samples of four models have been tested by cross-validation.     

卤素化学中的铈

卤素化学是聚合物工业生产中的重要组成部分,作为一种有吸引力的策略,它在活化天然气中轻链烷烃方面越来越受到重视.CeO2基催化剂在卤化氢回收方面有着令人兴奋的潜力,这使得基于卤素的小分子活化过程具有高效率.本文综述了近年来在高分子工业(聚氯乙烯、聚氨酯和聚碳酸酯)和天然气改质中轻烃活化方面应用的铈基催化剂的研究进展,讨论了铈催化剂的作用机理和面临的挑战,以期为未来催化材料的设计和应用提供帮助.     

氨基酰化酶与Cu(Ⅱ)相互作用的谱学研究

通过顺磁共振法、可见光谱法及酶活性测量研究从猪肾中提纯的氨基酰化酶（Aminoacylase,简称ACY）在pH4.0条件下与外加的Cu(Ⅱ）离子存在直接相互作用。结果发现：外加Cu(Ⅱ）离子进入ACY活性中心位点,取代了活性中心位点的Zn(Ⅱ）,使酶活性下降。随着pH变化生成的两种构型酶衍生物在溶液中可相互转化。