动脉粥样硬化光学成像探针研究进展

心血管疾病(Cardiovascular disease, CVD)是全球疾病致死的主要原因之一. 动脉粥样硬化(Atherosclerosis, AS)是引发各种CVD的首要危险因素, 其发生发展通常经历持续的慢性炎症过程. 因此, 及时高效地检测AS, 对于早期评估、 诊断和治疗CVD具有重要临床意义. 光学探针成像拥有极高的灵敏度和空间分辨率以及超快的信号采集处理速度, 被广泛应用于生物医学检测与成像. 本文综合评述了6种常见用于AS成像的光学探针, 涉及小分子荧光探针、 聚集诱导发光(Aggregate-induced emission, AIE)纳米探针、 量子点探针、 上转换纳米探针、 光声探针和多模态探针等; 并对各种探针的优缺点进行了分析比较. 在此基础上, 展望了光学探针在AS成像领域的发展前景, 并提出了相应建议.     

Obtaining the band structure of a complicated photonic crystal by linear operations

Absolute band gaps can be created by lifting the degeneracy in the bands of a photonic crystal.To calculate the band structure of a complicated photoinc crystal generated by e.g.symmetry breaking ,general forms of all possible linear operations are presented in terms of matrices and procedure to combine these operations in given.Other forms of linear operations (Such as the addition,subtraction,and translation transforms)are also presented to obtain an explicit expression for the Fourier coefficient of the dielectric function in the plane-wave expansion method.With the present method,band structures for various complicated photoinc crystals(related through these linear operations)can be obtained easily and quickly.As a numerical example,a large absolute and gap for a complicated photonic crystal structure of GaAs is found in the high reglon of normalized frequency.