Isolation,Crystal Structure and Antitussive Activity of 9S,9aS-neotuberostemonine

The title compound 9 S,9 aS-neotuberostemonine(1) was isolated from the 95% ethanol extract of the roots of Stemona tuberosa. The crystal structure of 1, C_922)H_(33)NO_4, was determined by single-crystal X-ray diffraction analysis. The crystal belongs to orthorhombic system, space group P212121, with a = 9.0115(11), b = 10.612(4), c = 22.074(3) ?, V = 2110.9(8) ?~3, Z = 4, Mr = 375.49, Dc = 1.182 g/cm3, λ= 0.71079 ?, μ = 0.080 cm-1, F(000) = 816, S = 1.019, R = 0.0579 and w R = 0.1358. A total of 3109 unique reflections were collected, of which 2902 were observed(I 2σ(I)). The absolute configuration of 1 could be assigned by referring to the conserved configuration of the methyl groups at C(13) and C(20). In the solid state, the molecules were linked into a chain along the a-axis through weak hydrogen bond C(11)–H(11 A)…O(2). Compound 1 shows significant inhibition of cough by 24%, 44% and 65% at doses of 50, 100 and 150 mg/kg, respectively.     

用矩阵的初等变换解矩阵方程Am×nXn×s=Bm×s

本文通过对一般的矩阵方程Am×nXn×s=Bm×s?B5木卣驛和B作初等行变换及初等列变换，给出了一般矩阵方程的求解方法。     

12C6+离子辐照对阿维链霉菌代谢效应研究

对12C6+ 离子辐照诱变高产阿维链霉菌株ZJAV-Y1-203 和原始菌株ZJAV-A-1 的摇瓶发酵pH 值、菌体浓度、碳源和氮源代谢进行了测定,研究了12C6+ 辐照对阿维链霉菌的代谢效应。在发酵前期(48h),原始菌株发酵液pH 值低于突变菌株;在发酵96~196 h,诱变高产菌株ZJAV-Y1-203 繁殖快,生长旺盛,N的利用率高;菌体浓度大于原始菌株的浓度,且发酵液的pH 稳定,菌体处于代谢相对更稳定期;在发酵144~240 h,诱变高产菌株ZJAV-Y1-203 对糖源消耗低于原始菌株ZJAV-A-1。这些结果表明,12C6+ 离子辐照对阿维链霉菌代谢影响有利于阿维菌素合成。pH value, mycelium concentration, carbon source and nitrogen metabolism in flask fermentation of the mutant high-producing strain ZJAV-Y1-203 and the original strain ZJAV-A1 have been investigated, in order to show the metabolic effect of avermitilis irradiated by ion beam of 12C6. In early stage (48 h) of the fermentation, pH value of the original fermentation was lower than that of the mutant strains. In 96~196 h of fermentation, the nitrogen utilization in the strains ZJAV-Y1-203 was higher than that in the original strains, its reproductive was fast, and its growing was vigorous. The mycelium concentration of ZJAV-Y1-203 was greater than the original strain, and the pH value of fermentation were stable, so its metabolism was relatively more stable. In 144240 h of fermentation, the strain ZJAV-Y1-203 on sugar consumption was less than the original strains. The effect of 12C6 ion irradiation on metabolism of Streptomyces avermitilis is conducive to the synthesis of avermectin.     

重离子束12C6+累进辐照诱变柠檬酸菌株选育研究

应用大剂量重离子束12C6+ 对菌株H3001 进行二次辐照选育,对初选获得的高产柠檬酸菌株进行摇瓶发酵试验及10~ 100 L 中试发酵罐试验,采用酸碱中和法测定发酵液中柠檬酸的含量。结果表明:当二次重离子12C6+剂量为857.8 Gy 时,致死率和正突变率达到最大值,分别为94.5% 和8%。通过摇瓶发酵试验,最终获得一株高产柠檬酸菌株hw317,控制该菌株发酵周期为60 h,柠檬酸酸度能达到19.2±0.2%。Heavy 12C6+ ion beams in various high doses were employed to irradiate H3001 strain for screening Aspergillus niger strain for hyper citric acid production. Three high-yield strains were obtained after shaker fermentation test. Among the three strains, the strain hw317 was implemented shaker fermentation for stability test and 10~100 L pilot fermentation tank for citric acid productive maximization. Acid-base neutralization method was applied to determinate the content of citric acid in fermented liquid. The results showed that: when the secondary heavy ion 12C6+ dose was 857.8 Gy, both of the fatality rate (94.5%) and the positive mutation rate (8%) were highest. Through the shaker fermentation tests and 10 ~ 100 L pilot fermentation test, one strain hw317 was screened and obtained for hyper citric acid production. Consequently, the final citric acid acidity can reach up to 19.2±0.2% with controlling fermentation cycle for 60 h.     

基于斯托克斯矢量的偏振成像仪器及其进展

偏振成像技术将景物的偏振信息转化为二维图像信息,从而可以和灰度图像一样对目标景物进行场景特征分析。介绍了基于斯托克斯矢量的偏振成像原理。按照获取斯托克斯矢量方法的不同,分别介绍了偏振片起偏、偏振棱镜分光和可变延迟波片调制三类分时偏振成像方式,分振幅、分孔径、分焦平面三种同时偏振成像方式。结合我国的制造水平,设计了双CCD渥拉斯顿棱镜同时偏振成像实验系统,并采集了实验图像。分析了各种偏振成像方式的优缺点。指出了偏振激光照明主动偏振成像、光谱偏振成像是偏振成像仪器进一步的发展方向。     

不同LET 12C6+离子对生防菌BJ1的辐射诱变效应

选取高低两个LET点(40和60keV/m),剂量点分别为50,100,200,400,600Gy进行辐照处理,研究了生防菌的存活率与突变率的关系,抑菌谱以及活性等。结果表明,在高LET条件下,低剂量辐照就可以得到较多的突变体,并且BJ1有较高的存活率和突变谱,有利于筛选优良的正突变体。因此高LET较低LET有更为明显的辐射诱变效应。     

12C6+离子对阿维链霉菌累进辐照诱变效应研究

选用12C6+ 离子束对阿维链霉菌诱变选育高产菌株与原始菌株进行辐照诱变, 研究其累进辐照效应。实验结果表明,在辐照剂量为10 Gy时, 原始菌株比诱变高产菌株存活率高, 抗辐射能力强;辐照剂量高于30 Gy时,诱变高产菌株比原始菌株存活率高, 抗辐射能力强。原始菌株正突变率最高的辐照剂量为50 Gy, 致死率99.43%,正突变率最高, 达34.2%;对诱变高产菌株辐照剂量为30 Gy,致死率94.97%,正突变率最高, 达23.5% 。累进辐照效应降低了最佳辐照剂量。 Mutagenic effect on the mutant high producing strain ZJAV Y1 203 and the original strain ZJAV A1 irradiated by ion beam of 12C6+ have been investigated. The experimental results indicated that the original strain has higher survival rate and stronger resistance to radiation than mutant high producing Strain at dose of 10 Gy. The mutant high producing strain has higher survival rate and stronger resistance to radiation than the original strain at the dose higher than 30 Gy. The lethality was 97% and the highest rate of orthomutation was 34.2%, when ZJAV A1 was irradiated by 50 Gy 12C6+ beam. The lethality was 94.97% and the highest rate of orthomutation was 23.5% when ZJAV Y1 203 was irradiated by 30 Gy 12C6+ beam. The best radiation dose is decreased by progressivity irradiation.     

准东煤中碱金属的赋存形式及其在燃烧过程中的迁移规律实验研究

对新疆煤采用三步化学提取实验(蒸馏水洗、醋酸铵洗、稀盐酸洗)以分析其碱金属赋存特性,对水溶的阴离子进行了离子色谱分析。分别检测了在不同温度、不同停留时间下准东煤灰的碱金属量,并用Factsage软件模拟该煤灰中碱金属的析出形式。结果表明,煤中的钠主要是水溶钠,钾主要以不可溶钾存在,水溶碱金属主要以水合离子形式的氯化物存在。准东煤中碱金属在400~600℃析出最快,主要是水溶态碱金属的释放,碱金属的释放主要发生在燃烧后期。灰中碱金属在高温下会与烟气中的成分发生反应,主要产物是氯化物以及氢氧化物。在700℃钠对准东煤中低温共融物的形成有很大贡献。     

液氮环境下的热载流子高功率微波探测器

为提高热载流子高功率微波探测器的灵敏度和降低环境温度对探测器性能的影响,开展了液氮环境下的热载流子探测器研究。提出了局部使用可阀合金块的BJ-100型热载流子探测器制作工艺,增强了探测器的抗温度冲击能力。测试结果表明,探测器硅片焊接的结合力大于4.9 N,能够承受从常温到液氮的反复温度冲击。利用100 kW微波源开展了热载流子探测器在室温和液氮环境下的灵敏度测试实验,结果表明:探测器输出波形与肖特基二极管检波器输出波形一致;在保持偏置电流相同的条件下,相较于常温环境,探测器在液氮环境下的相对灵敏度提升约20倍,输出电压可达V级。     

基底材料对溶胶-凝胶法制备BST薄膜的影响

利用溶胶-凝胶法在Si、SiO2/Si、刚玉粉处理过的Si和ZnO/Si基底上制备了Ba0.65Sr0.35TiO3薄膜。采用XRD、SEM等测试方法研究了基底种类对BST薄膜的结晶度及显微结构的影响。结果表明:经750℃热处理后BST薄膜都形成了完整的钙钛矿结构;与Si基底相比,BST薄膜与SiO2/Si基底晶格匹配度较小,结晶度和介电性能较差;而与刚玉粉处理过的Si基底和ZnO/Si基底匹配度较高,且沉积的BST薄膜结晶度高,晶粒发育较完善,晶粒间排列紧密,表面光滑无裂纹,其介电性能也较好。