Sharp inequalities related to the functional $$U_j$$ U j and some applications

Geometriae Dedicata - Sharp inequalities of the parameterized functional $$U_j$$ for Borel measures on the unit sphere in $${\mathbb {R}}^n$$ are established. As two applications, some inequalities...     

Effects of the curvature radius of a cylindrical shell on the stress intensity factors of surface cracks

The effects of the curvature radius of a cylindrical shell on stress intensity factors are investigated in circumferential (inner and outer) semielliptical surface cracks in a cylindrical shell. What is new in this paper is to have given: (1) The stress intensity factors for surface cracks in a cylindircal shell are determined by photoelastic technique. (2) By a special method photoelastic slices are handled for obtaining a clear caustic curve, and the stress intensity factors for surface cracks in a cylindrical shell are determined by the caustic method. (3) An approximate equation of curvature correction factor F_c is proposed. (4) Effects of the curvature radius R of a cylindrical shell on the stress intensity factors of surface cracks are obtained. The results of this paper are in fair agreement with already existing analytical results. The approximate equation of curvature correction factor F_c can be widely used for engineering purposes.     

Peroxynitrite-Promoted Persulfide Prodrugs with Protective Potential against Paracetamol Poisoning

The newly emerging persulfide prodrugs provide additional options for the profound study of persulfide, a fascinating molecule expected to intervene in biological functions and even diseases. Peroxynitrite is often the culprit in pathological processes characterized by oxidative stress, while the persulfide prodrug responsive to it is still pending. To enrich the family of redox-activated prodrugs, we designed prodrugs with a 2-oxo-2-phenylacetamide trigger, which achieved the release of persulfide via 1, 6-N, S-relay. The degradation of prodrugs and the formation of persulfides were confirmed to be peroxynitrite-responsible by the qualitative and quantitative studies based on LC-MS/MS methods and a spectrophotometry-based tag-switch strategy. Furthermore, these prodrugs showed potent peroxynitrite scavenging activity, cellular therapeutic potential against paracetamol poisoning in HepG2 and oxidative stress in H9c2, as well as desirable in vitro metabolic properties.     

Elimination of light chain tailing in reducing capillary electrophoresis with sodium dodecyl sulfate analysis of a monoclonal antibody

Capillary electrophoresis with sodium dodecyl sulfate (CE-SDS) is a common analytical technique for investigating the purity and molecular size heterogeneity of monoclonal antibody (mAb) drugs. In reducing CE-SDS analysis of mAb-A, the light chain (LC) peak exhibited severe tailing, seriously affecting the purity analysis. The purposes of this investigation are to clarify the source of tailing and develop a more appropriate CE-SDS method to eliminate LC tailing. The degree of LC tailing was closely related to the mAb concentration, SDS concentration, and injection amount, and more hydrophobic detergents, such as sodium hexadecyl sulfate (SHS) and sodium tetradecyl sulfate (STS), could be used instead of SDS to obtain better peak shapes. The results also indicated that the tailing was caused by the binding problem associated with SDS, and SHS/STS could provide a more stable and uniform complexation for the LC. In summary, the method we developed successfully eliminated the LC tailing and provided a robust characterization of mAb-A in reducing CE-SDS analysis.