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Chen BC Zhao R Bednarz MS Wang B Sundeen JE Barrish JC 《The Journal of organic chemistry》2004,69(3):977-979
A new efficient strategy was developed for the construction of the imidazo[1,5-a]quinoxalin-4-one ring system. The new method involves condensation of o-nitroaniline with glyoxylate in methanol followed by treatment of the resulting alpha-(o-nitroanilino)-alpha-methoxy acetate with tosylmethyl isocyanide (TosMIC) reagent to give 1-(o-nitrophenyl)imidazole-5-carboxylate. Reductive cyclization of the nitro imidazole carboxylate afforded imidazo[1,5-a]quinoxalin-4-one in three steps and 60% overall yield. The new method was successfully applied to the synthesis of BMS-238497, a novel and potent Lck inhibitor. 相似文献
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The synthesis of the fungal sex hormone antheridiol 总被引:1,自引:0,他引:1
J A Edwards J S Mills J Sundeen J H Fried 《Journal of the American Chemical Society》1969,91(5):1248-1249
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E.M. Gordon Jelka Pluščec N.G. Delaney S. Natarajan J. Sundeen 《Tetrahedron letters》1984,25(31):3277-3280
Amino acid derived chloromethyl ketones are shown to undergo a general dehydrohalogenation reaction under mild, basic, nonnucleophilic conditions to afford α-β-unsaturated ketones. 相似文献
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