全文获取类型
收费全文 | 1612篇 |
免费 | 74篇 |
专业分类
化学 | 1336篇 |
晶体学 | 27篇 |
力学 | 24篇 |
数学 | 34篇 |
物理学 | 265篇 |
出版年
2023年 | 16篇 |
2022年 | 12篇 |
2021年 | 24篇 |
2020年 | 33篇 |
2019年 | 46篇 |
2018年 | 28篇 |
2017年 | 16篇 |
2016年 | 44篇 |
2015年 | 37篇 |
2014年 | 42篇 |
2013年 | 83篇 |
2012年 | 131篇 |
2011年 | 125篇 |
2010年 | 58篇 |
2009年 | 62篇 |
2008年 | 89篇 |
2007年 | 81篇 |
2006年 | 105篇 |
2005年 | 96篇 |
2004年 | 81篇 |
2003年 | 62篇 |
2002年 | 77篇 |
2001年 | 30篇 |
2000年 | 35篇 |
1999年 | 30篇 |
1998年 | 8篇 |
1997年 | 9篇 |
1996年 | 7篇 |
1995年 | 4篇 |
1994年 | 12篇 |
1993年 | 12篇 |
1992年 | 7篇 |
1991年 | 17篇 |
1990年 | 12篇 |
1989年 | 8篇 |
1988年 | 9篇 |
1987年 | 8篇 |
1986年 | 10篇 |
1985年 | 11篇 |
1984年 | 19篇 |
1983年 | 10篇 |
1981年 | 8篇 |
1980年 | 13篇 |
1979年 | 8篇 |
1978年 | 15篇 |
1977年 | 6篇 |
1974年 | 5篇 |
1973年 | 4篇 |
1972年 | 4篇 |
1969年 | 4篇 |
排序方式: 共有1686条查询结果,搜索用时 15 毫秒
1.
Yuki Shintani Taku Ohtomi Dr. Aya Shibata Dr. Yoshiaki Kitamura Koichiro M. Hirosawa Prof. Kenichi G. N. Suzuki Prof. Masato Ikeda 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(8):e202104421
Aqueous self-assembly of short peptides has attracted growing attention for the construction of supramolecular materials for various bioapplications. Herein, we describe how the thermolysin-assisted biocatalytic construction of a dipeptide hydrazide from an N-protected amino acid and an amino acid hydrazide leads to the formation of thermally stable supramolecular hydrogels. In addition, we demonstrate the post-assembly modification of the supramolecular architectures constructed in situ tethering hydrazide groups as a chemical handle by means of fluorescence imaging. 相似文献
2.
Kento Nishikibe Keisuke Nishikawa Momochika Kumagai Matsumi Doe Yoshiki Morimoto 《化学:亚洲杂志》2022,17(1):e202101137
There are marine cytotoxic bromotriterpenoids, named the thyrsiferol family that are structurally characterized by some tetrahydropyran (THP) and tetrahydrofuran (THF) rings. The thyrsiferol family belongs to natural products that are often difficult to determine their stereostructures even by the current, highly advanced spectroscopic methods, especially in acyclic systems including stereogenic tetrasubstituted carbon centers. In such cases, it is effective to predict and synthesize the possible stereostructures. Herein, to elucidate ambiguous stereostructures and unassigned absolute configurations of aplysiol B, laurenmariannol, and saiyacenol A, members of the thyrsiferol family, we carried out their asymmetric chemical syntheses featuring 6-exo and 5-exo oxacyclizations of epoxy alcohol precursors and 6-endo bromoetherification of a bishomoallylic alcohol. In this paper, we report total assignments of their stereostructures through their asymmetric chemical syntheses and also their preliminary cytotoxic activities against some tumor cells. These results could not have been achieved without depending on asymmetric total synthesis. 相似文献
3.
4.
Toshiro Watanabe Tapan Kumar Mazumder Shiro Nagai Keisuke Tsuji Shigeru Terabe 《Analytical sciences》2003,19(1):159-161
A micellar electrokinetic chromatography (MEKC) method was developed for estimating the angiotensin-I converting enzyme (ACE) inhibitory activity by separating the hippuric acid liberated in the ACE reaction mixture in the presence of an inhibitor, captopril. The hippuric acid was successfully separated and detected by MEKC with a 25 mM sodium dodecyl sulfate solution in a 25 mM phosphate-50 mM borate buffer at pH 7.0; the total analysis took about 5 min. A good linear relationship was observed between the inhibitor and the peak area of hippuric acid release. No significant difference in the ACE inhibitory activity (IC50) of captopril (an antihypertensive medicine) or autolyzed-mushrooms (functional foods) was observed between the conventional method and the MEKC method. The MEKC method was found to be a useful technique for a rapid assay of the ACE inhibitory activity. 相似文献
5.
Tsuyoshi Kitamura 《Tetrahedron》2004,60(43):9649-9657
Synthesis of (+)-anthramycin was examined. A pyrrolobenzodiazepine skeleton could be synthesized by reductive cyclization of pyrrolidine derivative, which was obtained by enyne metathesis. The conjugated enamide ester part of (+)-anthramycin derivative was constructed by cross-metathesis. 相似文献
6.
Kosuke Morita Kouji Morimoto Daiya Kaji Yu Liang Zhao Atsushi Yoshida Toshimi Suda Akira Yoneda Tetsuya Ohnishi Hiromitsu Haba Eiji Ideguchi Hu Shan Xu Tao Zheng Hisaaki Kudo Keisuke Sueki Kenji Katori Isao Tanihata 《Acta Physica Hungarica A》2004,19(1-2):53-60
A gas-filled type of recoil separator for heavy element research was installed at an experimental hall of RIKEN Linear Accelerator facility to realize getting higher intensity of primary beam and long beam time. Performance of the separator was studied using target recoils and various nuclear reactions. The results show the high performance of the separator for heave element research. As an application of the GARIS, production and identification of an isotope of the 110th element 271[110] have been performed using the 208Pb(64Ni,1n)271[110] reaction. Three decay chains coincide well both in decay times and energies with the ones reported by the group of SHIP experiment at GSI, Germany. Our results provide a confirmation of the synthesis of an isotope 271[110] of element 110. 相似文献
7.
8.
9.
Toshiyuki Oyama Akira Kitamura Eiichi Sato Masao Tomoi 《Journal of polymer science. Part A, Polymer chemistry》2006,44(8):2694-2706
The factors affecting pattern‐forming properties in reaction development patterning were examined with polyarylates with various bisphenol moieties. The developability of the photosensitive polyarylates was dependent on the properties of the subtituent (R) in the bisphenol moieties. The development time decreased in the following order: R?C(CH3)2 > fluorenyl unit ? phenolphthalein unit > C(CF3)2 > SO2. This order agreed with that of the reactivity between the polyarylates and ethanolamine, and these orders can be explained by pKa of the bisphenol used to prepare the polyarylates. The development with NH2? R′? OH resulted in successful positive‐tone pattern formation. However, pattern formation with the developers containing NH2? R′? OCH3 was unsuccessful. © 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 2694–2706, 2006 相似文献
10.