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Formation of Supramolecular Nanostructures through in Situ Self-Assembly and Post-Assembly Modification of a Biocatalytically Constructed Dipeptide Hydrazide** |
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| Authors: | Yuki Shintani Taku Ohtomi Dr Aya Shibata Dr Yoshiaki Kitamura Koichiro M Hirosawa Prof Kenichi G N Suzuki Prof Masato Ikeda |
| Institution: | 1. Department of Life Science and Chemistry Graduate School of Natural Science and Technology, Gifu University, 1-1 Yanagido, Gifu, 501-1193 Japan;2. Institute for Glyco-core Research (iGCORE), Gifu University, 1-1 Yanagido, Gifu, 501-1193 Japan |
| Abstract: | Aqueous self-assembly of short peptides has attracted growing attention for the construction of supramolecular materials for various bioapplications. Herein, we describe how the thermolysin-assisted biocatalytic construction of a dipeptide hydrazide from an N-protected amino acid and an amino acid hydrazide leads to the formation of thermally stable supramolecular hydrogels. In addition, we demonstrate the post-assembly modification of the supramolecular architectures constructed in situ tethering hydrazide groups as a chemical handle by means of fluorescence imaging. |
| Keywords: | biocatalysis helical nanoribbons peptides post-assembly modifications self-assembly supramolecular hydrogels |