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通过水热法合成由临床用药蒙脱石(Montmorillonite, MMT)负载的高效纳米酶氧化铈(Cerium dioxide, CeO2), 通过开展体内外实验, 拓展其在炎症性肠病治疗中的普适性. 结果显示, CeO2@MMT具有良好的类超氧化物歧化酶活性及类过氧化氢酶活性, 并且在小鼠克罗恩病的治疗中体现了明显的疗效及优异的生物安全性, 为CeO2@MMT的应用拓宽了方向. 相似文献
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THE STIMULATORY EFFECT OF HEAVY METAL CATIONS ON PROLIFERATION OF AORTIC SMOOTH MUSCLE CELLS 总被引:1,自引:0,他引:1
Heavy metal cations Cd~(2+), Pb~(2+), and Hg~(2+)were added to substitute for Ca~(2+)in culture media to study their effect on the relationship between CaM and the proliferation of cultured rabbit aortic smooth muscle cells (ASMC). It was found that all the heavy metal cations studied stimulated the proliferation of ASMC in varying degrees, increased the CaM content in cells at late G_1 stage and decreased the activity of cAMP PDE. These results suggest that the adverse effect of heavy metals may be related to the pathogenesis of atherosclerosis and hypertensive disease. 相似文献
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