金催化的炔烃羟基化反应: 合成2取代苯并呋喃化合物

本文报道了一种以邻炔基苯酚为原料,通过金催化的炔烃羟基化反应合成2取代苯并呋喃的方法. 该方法可以在温和的条件下快速以高产率得到各种2取代苯并呋喃. 关键前体邻炔基苯酚可以很容易由Sonogashira 反应制备.     

(7R,10S)-Boivinianin B的不对称合成

报道了一种基于Dehydro-α-curcumene(4)为关键中间体, 以Sharpless不对称双羟化反应和碘催化的分子内环化成醚反应为关键步骤, 构建2,2,5位三取代的四氢呋喃骨架的方法, 完成了(7R,10S)-Boivinianin B(1)的不对称合成. 合成路线简捷, 对此类化合物的合成有一定的借鉴意义.     

12C6+离子束辐照菘蓝干种子当代效应

利用兰州重离子研究装置(HIRFL) 提供的12C6+ 离子束辐照菘蓝干种子(辐照剂量为10,35,60,90 和140 Gy,剂量率20 Gy/min),探讨了重离子束辐照对菘蓝M1代的生物学效应。研究发现,不同剂量的12C6+ 离子束辐照后,菘蓝种子的发芽率、成苗率、株高、根长和根冠比等生物学性状以及对菘蓝中靛玉红和4(3H) 喹唑酮含量均发生了变化,其中株高和根长随辐照剂量的增加而降低;菘蓝叶和根中的4(3H) 喹唑酮和靛玉红的含量随辐照剂量增加呈马鞍形增加关系。这表明:12C6+ 重离子束辐照菘蓝种子具有明显的当代损伤效应, 并可显著提高菘蓝中靛玉红和4(3H) 喹唑酮的含量,其辐照适宜诱变剂量为35 Gy。To investigate the M1 biological effects of heavy ions on Isatis indigotica Fort, its dry seeds were irradiated by 12C6+ beam with the dose of 0, 10, 35, 60, 90 and 140 Gy respectively,at the rate of 20 Gy/min delivered by the Heavy Ion Research Facility in Lanzhou (HIRFL). The results showed that biological characters such as germinating rate, germinating potential, survival rate, plant height, root height and root-shoot ratio were changed after irradiation. Moreover, the plant height and root height decreased in a dos dependent manner. The indirubin and 4(3H) quinazolinone content of Isatis indigotica Fort was improved and exhibited obviously “saddle” trends with irradiation dose increasing.Data suggest that exposure with low-dose 12C6+ to seeds of Isatis indigotica Fort has obvious injury effects at the first generation, and the active ingredient content of Isatis indigotica Fort may be improved by carbon ion beamirradiation. It is concluded that the suitable irradiation dose of mutation breeding is 35 Gy for the seeds of Isatis indigotica Fort.     

碳离子束辐照处理对牛至精油微胶囊的缓释特性及抗鸡球虫病活性的影响

利用不同剂量的碳离子束辐照处理牛至精油微胶囊,研究对其缓释特性及抗鸡球虫病活性的影响。研究结果表明,通过碳离子束处理的牛至精油微胶囊,其主要活性成分百里香酚和香芹酚含量未发生变化,辐照处理后反应收率及产品的生物活性均提高,其中400 Gy剂量处理的牛至精油微囊的收率和生物活性均最高,收率达68.44%。通过对感染柔嫩艾美耳球虫的小鸡喂食后,其盲肠和十二指肠肿胀明显减轻,血液性内容物明显减少,血便指数在感染的第七天已降为0,抗球虫指数（ACI）达到179.39。The purpose of this study is using different doses of carbon ion beam irradiation on oregano essential oil microcapsules, to investigate function of control release and anticoccidial activity in chickens. The results showed that the content of main components in oregano essential oil microcapsules after carbon ion beam irradiation, thymol and carvacrol, have little change. Moreover, it can obtain more object products and better bioactivity after the irradiation treatment. Among these different doses of irradiation, our findings showed that Microcapsule groups with 400 Gy dose irradiation showed the highest yield (68.44%) and the best anticoccidial activity. After feeding chickens infected with Eimeria tenella, the swelling of caecum and duodenum were significantly mitigated and blood contents were also significantly reduced. The bloody stool index of chickens was as low as zero on the seventh day of infection, and the anticoccidial index (ACI) is 179.39.