Spectroscopic Studies on the Interaction of Vitamin C with Bovine Serum Albumin

The mechanism of binding of vitamin C (VC) with bovine serum albumin (BSA) was investigated by spectroscopic methods under simulated physiological conditions. VC effectively quenched the intrinsic fluorescence of BSA. The binding constants K _A, and the number of binding sites, n, and corresponding thermodynamic parameters ΔG ^Θ , ΔH ^Θ and ΔS ^Θ between VC and BSA were calculated at different temperatures. The primary binding pattern between VC and BSA was interpreted as being a hydrophobic interaction. The interaction between VC and BSA occurs through static quenching and the effect of VC on the conformation of BSA was also analyzed using synchronous fluorescence spectroscopy. The average binding distance, r, between the donor (BSA) and acceptor (VC) was determined based on Förster’s theory and was found to be 3.65 nm. The effects of common ions on the binding constant of VC-BSA were also examined.     

QSPR study for the prediction of half-wave potentials of benzoxazines by heuristic method and radial basis function neural network

The half-wave potential (E_1/2) is an important electrochemical property of organic compounds. In this work, a quantitative structure-property relationship (QSPR) analysis has been conducted on the half-wave reduction potential (E_1/2) of 40 substituted benzoxazines by means of both a heuristic method (HM) and a non-linear radial basis function neural network (RBFNN) modeling method. The statistical parameters provided by the HM model (R² =0.946; F=152.576; RMSCV=0.0141) and the RBFNN model (R²=0.982; F=1034.171 and RMS =0.0209) indicated satisfactory stability and predictive ability. The obtained models showed that benzoxazines with larger Min valency of a S atom (MVSA), lower Relative number of H atom (RNHA) and Min n-n repulsion for a C-H bond (MnnRCHB) and Minimal Electrophilic Reactivity Index for a C atom (MERICA) can be more easily reduced. This QSPR approach can contribute to a better understanding of structural factors of the organic compounds that contribute to the E_1/2, and can be useful in predicting the E_1/2 of other compounds.      

THE POINTWISE ESTIMATES TO SOLUTIONS FOR 1-DIMENSIONAL LINEAR THERMO-VISCO-ELASTIC SYSTEM

In this paper, we study the linear thermo-visco-elastic system in one-dimensional space variable. The mathematical model is a hyperbolic-parabolic partial differential system. The solutions of the system show some decay property due to the parabolicity. Based on detailed analysis on the Green function of the system, the pointwise estimates of the solutions are obtained, from which the generalized Huygens’ principle is shown.     

水面舰艇舰员对水下爆炸冲击响应

通过建立站立、坐姿、行走状态下的人体集中参数模型,分析水下爆炸载荷作用下舰员的冲击响应,讨论了水下爆炸冲击强度与人体冲击损伤的关系,并依据常用的损伤标准进行损伤程度的评估,为水面舰艇舰员冲击防护提供指导.     

Nanocrystalline Fe - 1 wt. %C compacts obtained by high pressure torsion of mechanically alloyed powder

Powders of a nanocrystalline Fe - 1 wt.% C alloy produced by mechanical alloying were consolidated to form a bulk nanocrystalline sample by means of high pressure torsion at 540°C. The density of the compacts reached 96 % of the theoretical density. The fracture stress of the material was 1 GPa and the microhardness 7.5 GPa, respectively. The grain size was approximately 70 nm and remained stable up to 700°C. The material contained fine particles of oxides and carbides.     

花生中丁酰肼残留量的气相色谱法测定

提出了一种新的简单易行且相当便捷的方法,对样品的提取和衍生化反应的各种影响因素,色谱分离和测定的最佳条件进行了测定。方法的准确度和精密度指标均符合残留量分析方法的要求,对同一试样进行多次平行独立测定时其标准偏差不大于０．４％,变异系数不大于５．２５％,最低检测限为０．０２ｍｇ／ｋｇ,该方法适用于油籽、花生、苹果等级其制品中丁酰肼残留量的测定,可作为相关实验室的例行分析方法。     

库的量子关联相干辅助系统能量提取的研究

基于单模微腔与二能级原子系综(库)构成的混合动力学模型,探索了非平衡库中量子关联相干(quantum correlated coherence, QCC)[Tan K C, et al. 2016 Phys. Rev. A 94, 022329])对系统动力学的影响.推导了量子关联相干库下系统演化的动力学方程.借助于含QCC的类GHZ库及其对应的参考库,清晰地揭示了非平衡库中QCC扮演着热力学资源的角色——能够有效辅助系统从库中提取更多能量.同时,结合解析与数值模拟方法研究了类GHZ库的有效温度和系统与库间的耦合参数对QCC能量效应的影响.研究发现, QCC对腔场的能量贡献不仅依赖于库的有效温度,而且也和系统与库间的耦合参数有关.这与二能级原子构成的传统的热库的情况(腔场从热库中提取的能量仅仅依赖于库的有效温度即二能级原子的热布局)完全不同.此外,研究发现QCC可视作一类优质的热力学资源,在特定条件下其对系统的能量贡献远大于原子热布局的贡献.因此, QCC将是高输出功率或高效率量子热机设计中的一类重要燃料.     

无人水下航行器势场航路规划方法研究

对运动障碍威胁环境下UUV航路规划问题进行了研究。首先分别对规划过程中固定障碍、运动障碍建立了排斥势场,对目标点建立了吸引势场,将航路规划问题转变为寻找最优势场点问题;然后提出一种改进的粒子群算法(NPSO),在UUV航路规划过程中,寻找距离当前路径点固定步长范围内的最优势场点,将其作为下一路径点,最终实现UUV在运动障碍威胁环境中的航路规划;最后对所提方法进行了仿真验证,UUV可以有效躲避固定障碍与运动障碍威胁,寻找到较优航路,取得了较好的仿真效果。     

简单自相关代数迭代重建算法

创建了简单自相关代数迭代重建算法(simple self-correlative algebraic reconstruction technique, SSCART),分析了其重建效果。采用数值模拟的方法,对代数迭代法(algebraic reconstruction technique, ART)与SSCART两种算法进行了计算机模拟,分析了模拟效果和重建精度。结果发现,SSCART算法的重建精度均方误差(mean square error, MSE)指标在10-4数量级上比ART的降低了65%[(ART的MSE值-SSCART的MSE)/ART的MSE],峰值相对误差(peak error, PE)指标在10-2数量级上降低了99.9%。计算上仅仅比ART多1个除数因子,所以SSCART具有算法简单、易于实现、重建精度高、稳定性好等优点。就作者检索的文献看是目前最优秀的代数迭代法。