Novel gold nanoparticle trimer reporter probe combined with dry-reagent cotton thread immunoassay device for rapid human ferritin test

We reported here for the first time on the use of cotton thread combined with novel gold nanoparticle trimer reporter probe for low-cost, sensitive and rapid detection of a lung cancer related biomarker, human ferritin. A model system comprising ferritin as an analyte and a pair of monoclonal antibodies was used to demonstrate the proof-of-concept on the dry-reagent natural cotton thread immunoassay device. Results indicated that the using of novel gold nanoparticle trimer reporter probe greatly improved the sensitivity comparing with traditional gold nanoparticle reporter probe on the cotton thread immunoassay device. The assay avoids multiple incubation and washing steps performed in most conventional protein analyses. Although qualitative tests are realized by observing the color change of the test zone, quantitative data are obtained by recording the optical responses of the test zone with a commercial scanner and corresponding analysis software. Under optimal conditions, the cotton thread immunoassay device was capable of measuring 10 ng/mL human ferritin under room temperature which is sensitive enough for clinical diagnosis. Moreover, the sample solution employed in the assays is just 8 μL, which is much less than traditional lateral flow strip based biosensors.     

Logistic回归模型的统计诊断

统计诊断的主要任务就是通过诊断统计量检测已知观测数据在用既定模型拟合时的合理性,主要是找出数据当中的异常点或强影响点。本文主要研究Logostic回归模型的诊断统计量和诊断统计图。用牛顿迭代法给出Logistic回归模型的极大似然估计值,根据扰动模型得到传统的诊断统计量,结合残差、杠杆值和系数变化三者构造新的诊断统计量,绘制新的诊断统计图,通过模拟研究说明新的诊断统计量的有效性,最后用一个实际案例说明新的诊断方法的应用并进一步验证其优越性。     

爆炸破碎区域划分的模糊数学方法

本文以最大径向应力,最大剪应力和最大切向应力为主要的破碎准则,利用二元分配法分析了诸破碎准则间权的分配,采用正态函数、降正态函数和升正态函数为各个破碎准则的录属函数,由此提出了爆炸破碎的过粉碎区,初始裂缝区和纯粹拉断区划分的综合评价方法。实例证明,对于大药量或小药量爆炸,以上方法均可成立。     

基于贝叶斯网络的智能故障诊断方法

首先提出了基于贝叶斯网络的智能故障诊断方法，它对于解决复杂设备诊断问题中存在的不确定性，关联性具有很大的优质。然后阐述了贝叶斯网络模型的数学描述及基于贝叶斯网络的故障诊断方法的基本思路和决策算法。最后以某型SINS／GPS组合导航系统的故障诊断应用实例说明了该方法的有效性。     

小波分析技术在陀螺故障诊断中的应用研究

小波分析是一种全新的时一频两维分析技术，其对高频突变信号和低频缓变信号的分析有其独特的优点。本文分析了小波分析技术的原理，提出了将其引入机械设备故障诊断中的方法。通过对有故障陀螺振动信号的多尺度分析，研究故障信号小波变换轴心轨迹分量图，建立典型故障特征模型，从而对单故障及多故障问题进行分析与诊断。     

惯导系统故障诊断技术的特点

对惯导系统故障诊断技术的特点作了简要而全面的论述。论述的内容包括基本功能、故障分类、故障现象及原因，指出各类故障诊断方法的问题，并提出了智能故障诊断构思。     

机载惯导两套配置时的故障诊断研究

分析了飞机惯导采用两套配置时对不同故障的诊断方法,主要分为两类:一类是借助两个平台四个加速度计的输出,诊断陀螺慢漂移过大的问题,文中给出了两平台相对转角及其补偿的实现方法;另一类是借助大气数据系统和解析余度的方法,通过建立故障诊断模型,检测两个互不相关惯导系统的故障,文中给出了方案,指出了难点。     

Noise Field in the Human Chest Due to Turbulent Flow in a Larger Blood Vessel

An acoustic model of a larger human blood vessel is developed. This model takes into account the main features of the acoustic generation and propagation of noise in the human chest from the source (turbulent pressure fluctuations in blood flow) to a receiver resting on the skin, and allows the consideration of a simple stenotic narrowing in the vessel. The low Mach number turbulent wall pressure models of Corcos, Chase, Ffowcs Williams, and Smol'yakov and Tkachenko are used to describe random sources in the vessel. The relationships obtained permit one to analyse the dependence of the resultant acoustic field in the thorax on the parameters of the blood flow and the vessel, and show the possibility of finding characteristic signs of the presence of a stenosis by comparison of noise fields from intact and diseased arteries. This revised version was published online in July 2006 with corrections to the Cover Date.     

基于多级BP神经网络的无线电罗盘多故障诊断研究

【】本文针对过拟合现象提出了基于提前停止法的学习率可变BP算法,运用多级BP神经网络诊断思想,提出了基于多级BP神经网络的多故障诊断方法。文中根据BP神经网络改进算法和网络撕裂法,对具体的机载无线电罗盘测向电路建模仿真,将复杂的无线电罗盘电路分解为3个子网络,并对每个子网络建立合适的故障集,快速准确诊断得出电路中的故障模块。     

Solid-state gas sensors for breath analysis: A review

The analysis of volatile compounds is an efficient method to appraise information about the chemical composition of liquids and solids. This principle is applied to several practical applications, such as food analysis where many important features (e.g. freshness) can be directly inferred from the analysis of volatile compounds.