Synthesis and characterization of insulin-5-Fu conjugate,enabling insulin as multi-drug carrier via dendritic approach

To enable insulin as multi-drug carrier, we designed and synthesized dendritic linker molecule bearing three 5-Fluorouracil residues at the branch ends. The new conjugate showed excellent water solubility. The stabilities under different conditions were investigated. The results showed that the conjugate was a potential prodrug to release free 5-Fu.     

Synthesis, Characterization, Spectroscopic Properties of 2-（4-Dimethylaminophenyl）-5-fluoro-6-（morpholin-4-yl）-1H-benzimidazole and its Interaction with Calf Thymus DNA

Benzimidazole compounds have attracted a renewed interest recently owing to theirpotential applications in high-performance composite materials, electronic chemicals,photosensitive materials, and their special potentials in biological and/or medicinalapplication1,2. Typically, aromatic compounds with near planar structures and contain-ing hydrogen-donor groups or groups, which are capable of being protonated, havespecial interactions with DNA via intercalation, hydrogen-bonding, and so on3.Me…     

New conversion of Friendlnder reaction of 3-amino-1H-benzo[f]chromene-2-carbonitriles with cyclohexanone

Two different skeletons of heterocyclic compounds,quinoline and quinazolinone analogs could be obtained by a novel one-pot synthesis from substituted 3-amino-1 H-benzo[f]chromene-2-carbonitrile derivatives and cyclohexanone in DMF in the catalyst of anhydrous zinc chloride under reflux.A plausible mechanism was proposed.     

Synthesis,X-Ray Structure and Characterization of a Triruthenium Cluster Complex Ru_3~Ⅲ(μ_3-O)(μ-CH_3COO)_6(py)_2Cl with Four Steps One-electron Redox Processes

Great attention is currently paid to the synthesis of polynuclear transition metal complexes as well as their photochemical, photophysical, and electrochemical properties. The design of multicomponent systems capable of performing useful light- and/or redox-induced function is of special interest1. The oxo-centered carboxylate-bridge trinuclear ruthenium clusters have been investigated extensively during recent decades because they have remarkable electron-transfer properties, intense visibl…     

Structural Study of Inclusion Complex of Andrographolide with β-Cyclodextrin Prepared under Microwave Irradiation

Andrographolide (Andro) (Figure 1) is a diterpene lactone isolated from Andrographis paniculate Nees1. It has showed several biological activities including analgesic, antipyretic and anti-inflammatory effects2. However, its poor water solubility and unstability towards oxygen restrained its application. In pharmaceutics, b-CD is used to increase solubility and stability3. We have prepared the inclusion compound of Andro/b-CD (Figure 2) under microwave irradiation4. It has been found…     

Novel Stereoselective Synthesis of (E)-a,b-Unsaturated Esters by the Tandem Reaction of Deprotonation-Oxidation-Wittig Reaction from Phosphonium and Arsonium Salt

Wittigreactionisoneofthemostimportantmethodfortheformationofcarbon-carbondoublebondandhasbeenwidelyusedinthesynthesisofnaturalproducts1,2.Recentlyitwasfoundthatalcoholscanundergoinsituoxidation-Wittigreactionwithphosponiumylidestogivecorrespondingolefinationproducts,whichhasgreatpotentialutilitiesinorganicsynthesis3.Tosimplifytheprocedureofthereactionfurther,weconsideredtocombinethedeprotonationofylide,oxidationofalcoholandWittigreactionintoonetandemreaction.Weutilizedphosphoniumorarsoniumsal…     

Formation of α,α''''-Bis(substituted benzylidene)cycloalkanones from Masked Aldehydes Promoted by Samarium(III) Triiodide

~~Formation of α,α'-Bis(substituted benzylidene)cycloalkanones from Masked Aldehydes Promoted by Samarium(III) Triiodide~~     

Hydrogen peroxide biosensor based on electrodeposition of zinc oxide nanoflowers onto carbon nanotubes film electrode

A new amperometric biosensor for hydrogen peroxide was developed based on adsorption of horseradish peroxidase at the glassy carbon electrode modified with zinc oxide nanoflowers produced by electrodeposition onto multi-walled carbon nanotubes （MWNTs） film. The morphology of the MWNTs/nano-ZnO electrode has been investigated by scanning electron microscopy （SEM）, and the electrochemical performance of the electrode has also been studied by amperometric method. The resulting electrode offered an excellent detection for hydrogen peroxide at -0.11 V with a linear response range of 9.9×10^-7 to 2.9×10^-3 mol/L with a correlation coefficient of 0.991, and response time 〈5 s. The biosensor displays rapid response and expanded linear response range, and excellent stability.     

Electrochemical oxidation behavior of hydroxypivalaldehyde in the ionic liquids

The similar electrochemical oxidation behaviors of hydroxypivalaldehyde in ionic liquids （ILs） medium, C4MIMPF6, C4MIMBF4 and CsMIMPF6, are investigated using classic electrochemical methods, respectively. Only the product, hydroxypivalic acid is detected by high performance liquid chromatography （HPLC）. It can be conferred that the electrochemical oxidation of hydroxypivalaldehyde consists of two successive one-electron irreversible reactions at glass carbon （GC） electrode and the possible reaction mechanism in the ILs is proposed firstly. The diffusion coefficients of hydroxypivalaldehyde are obtained according to the electrochemical characteristics of hydroxypivalaldehyde in C4MIMPF6, C4MIMBF4 and CsMIMPF6.     

A Novel Synthesis of (-)-10-epi-α-Cyperone

The eudesmane derivative, (-)-10-epi-α-cyperone 1, is widely used as a chiral starting material for the synthesis of other fused-ring sesquiterpenes1. The first synthetic work was reported by Howe and co-workers via condensation of (+)-dihydrocarvone 2 with 1-diethylaminopentan-3-one methiodide in 32% yield2. Previously, our group reported the synthesis of compound 1 by treating ketone 2 with ethyl vinyl ketone (EVK) directly under different conditions1a, but the yields were not satisfacto…